{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:33Z","timestamp":1791404913210,"version":"4.3.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Filarial parasites have to trespass many barriers to successfully settle within their mammalian host, which is equipped with mechanical borders and complex weaponry of an evolved immune system. However, little is known about mechanisms of early local events in filarial infections. In this study, bone marrow-derived dendritic cells not only upregulated activation markers CD40 and CD80 upon in vitro stimulation with filarial extracts, but also secreted CCL17, a chemokine known to be produced upon microbial challenge. Mice deficient for CCL17 had an up to 4-fold higher worm burden compared with controls by day 10 of infection with the murine filaria Litomosoides sigmodontis. Also, numbers of mast cells (MCs) invading the skin and degranulation were significantly increased, which was associated with enhanced vascular permeability and larval establishment. This phenotype was reverted by inhibition of MC degranulation with disodium cromoglycate or by blockade of histamine. In addition, we showed that CCL17-mediated vascular permeability was dependent on the presence of Wolbachia endosymbionts and TLR2. Our findings reveal that CCL17 controls filarial larval entry by limiting MC-dependent vascular permeability.<\/jats:p>","DOI":"10.4049\/jimmunol.1000612","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T04:01:37Z","timestamp":1300075297000},"page":"4845-4852","source":"Crossref","is-referenced-by-count":42,"title":["CCL17 Controls Mast Cells for the Defense against Filarial Larval Entry"],"prefix":"10.1093","volume":"186","author":[{"given":"Sabine","family":"Specht","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta K","family":"Frank","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Alferink","sequence":"additional","affiliation":[{"name":"Institute of Molecular Psychiatry, University of Bonn , 53105 Bonn ,","place":["Germany"]},{"name":"Department of Psychiatry, University of Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Dubben","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E","family":"Layland","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Denece","sequence":"additional","affiliation":[{"name":"USM 307, Parasitologie Compar\u00e9e et Mod\u00e8les Exp\u00e9rimentaux, Mus\u00e9um National d\u2019Histoire Naturelle , Paris Cedex 05 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Bain","sequence":"additional","affiliation":[{"name":"USM 307, Parasitologie Compar\u00e9e et Mod\u00e8les Exp\u00e9rimentaux, Mus\u00e9um National d\u2019Histoire Naturelle , Paris Cedex 05 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Leibniz Research Institute for Environmental Medicine, University of D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten J","family":"Kirschning","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University of Duisburg-Essen , 45147 Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Martin","sequence":"additional","affiliation":[{"name":"USM 307, Parasitologie Compar\u00e9e et Mod\u00e8les Exp\u00e9rimentaux, Mus\u00e9um National d\u2019Histoire Naturelle , Paris Cedex 05 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn , 53105 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,15]]},"reference":[{"key":"2025032411204353600_r1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-3024.1993.tb00572.x","article-title":"The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice","volume":"15","author":"Grencis","year":"1993","journal-title":"Parasite Immunol."},{"key":"2025032411204353600_r2","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1182\/blood.V86.5.1968.bloodjournal8651968","article-title":"Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N. brasiliensis infection","volume":"86","author":"Newlands","year":"1995","journal-title":"Blood"},{"key":"2025032411204353600_r3","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4049\/jimmunol.172.4.2424","article-title":"Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response","volume":"172","author":"Morimoto","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411204353600_r4","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.192.12.1849","article-title":"Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1","volume":"192","author":"Knight","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032411204353600_r5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411204353600_r6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S0031182097002278","article-title":"Mast cell distribution in nodules of Onchocerca volvulus from untreated patients with generalized onchocerciasis","volume":"116","author":"Wildenburg","year":"1998","journal-title":"Parasitology"},{"key":"2025032411204353600_r7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0001-706X(98)00029-1","article-title":"Mast cells in onchocercomas from patients with hyperreactive onchocerciasis (sowda)","volume":"70","author":"Korten","year":"1998","journal-title":"Acta Trop."},{"key":"2025032411204353600_r8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3024.2005.00792.x","article-title":"Immunomodulation by filarial nematodes","volume":"27","author":"Hoerauf","year":"2005","journal-title":"Parasite Immunol."},{"key":"2025032411204353600_r9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.20021859","article-title":"Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen","volume":"197","author":"Alferink","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032411204353600_r10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2249.2005.02910.x","article-title":"Chemokines in onchocerciasis patients after a single dose of ivermectin","volume":"142","author":"Fendt","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"2025032411204353600_r11","doi-asserted-by":"crossref","first-page":"22364","DOI":"10.1074\/jbc.M901528200","article-title":"Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis","volume":"284","author":"Turner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2025032411204353600_r12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4049\/jimmunol.178.2.1068","article-title":"Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM","volume":"178","author":"Hise","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411204353600_r13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4049\/jimmunol.173.1.437","article-title":"The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4","volume":"173","author":"Brattig","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411204353600_r14","doi-asserted-by":"crossref","first-page":"13190","DOI":"10.1074\/jbc.M610340200","article-title":"Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4","volume":"282","author":"Spiller","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2025032411204353600_r15","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.169.4.1978","article-title":"Accelerated clearance of Escherichia coli in experimental peritonitis of histamine-deficient mice","volume":"169","author":"Hori","year":"2002","journal-title":"J. Immunol."},{"key":"2025032411204353600_r16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijpara.2007.12.006","article-title":"Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms","volume":"38","author":"Arumugam","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"2025032411204353600_r17","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1128\/IAI.72.11.6287-6293.2004","article-title":"Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis","volume":"72","author":"Specht","year":"2004","journal-title":"Infect. Immun."},{"key":"2025032411204353600_r18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3760\/cma.j.issn.0366-6999.2009.03.016","article-title":"Mast cell degranulator compound 48\u201380 promotes atherosclerotic plaque in apolipoprotein E knockout mice with perivascular common carotid collar placement","volume":"122","author":"Tang","year":"2009","journal-title":"Chin. Med. J. (Engl.)"},{"key":"2025032411204353600_r19","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.embor.7400814","article-title":"Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction","volume":"7","author":"Luplertlop","year":"2006","journal-title":"EMBO Rep."},{"key":"2025032411204353600_r20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.micinf.2008.11.003","article-title":"Filarial infection induces protection against P. berghei liver stages in mice","volume":"11","author":"Fern\u00e1ndez Ruiz","year":"2009","journal-title":"Microbes Infect."},{"key":"2025032411204353600_r21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/eji.200838727","article-title":"Early recruitment of natural CD4+Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection","volume":"39","author":"Taylor","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025032411204353600_r22","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1371\/journal.pntd.0000217","article-title":"Of mice, cattle, and humans: the immunology and treatment of river blindness","volume":"2","author":"Allen","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2025032411204353600_r23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0006-2952(96)00243-2","article-title":"Characterization of the 78 kDa mast cell protein phosphorylated by the antiallergic drug cromolyn and homology to moesin","volume":"52","author":"Correia","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"2025032411204353600_r24","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(00)04581-5","article-title":"Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment","volume":"357","author":"Hoerauf","year":"2001","journal-title":"Lancet"},{"key":"2025032411204353600_r25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00430-007-0062-1","article-title":"Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study","volume":"197","author":"Hoerauf","year":"2008","journal-title":"Med. Microbiol. Immunol. (Berl.)"},{"key":"2025032411204353600_r26","doi-asserted-by":"crossref","first-page":"22364","DOI":"10.1074\/jbc.M901528200","article-title":"Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 (TLR2\/6) to induce disease manifestations of filariasis","volume":"284","author":"Turner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2025032411204353600_r27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/PL00008258","article-title":"IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis","volume":"189","author":"Martin","year":"2000","journal-title":"Med. Microbiol. Immunol. (Berl.)"},{"key":"2025032411204353600_r28","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1128\/IAI.69.11.7067-7073.2001","article-title":"B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection","volume":"69","author":"Martin","year":"2001","journal-title":"Infect. Immun."},{"key":"2025032411204353600_r29","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1046\/j.1365-3156.1997.d01-218.x","article-title":"Early reduction of the challenge recovery rate following immunization with irradiated infective larvae in a filaria mouse system","volume":"2","author":"Le Goff","year":"1997","journal-title":"Trop. Med. Int. Health"},{"key":"2025032411204353600_r30","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.4049\/jimmunol.181.9.6456","article-title":"Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi","volume":"181","author":"McSorley","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411204353600_r31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1051\/parasite\/1996031025","article-title":"The fate of the filaria Litomosoides sigmodontis in susceptible and naturally resistant mice","volume":"3","author":"Mar\u00e9chal","year":"1996","journal-title":"Parasite"},{"key":"2025032411204353600_r32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0031182099005533","article-title":"Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae","volume":"120","author":"Le Goff","year":"2000","journal-title":"Parasitology"},{"key":"2025032411204353600_r33","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1365-2222.2005.02203.x","article-title":"CCL17 and CCL22 attenuate CCL5-induced mast cell migration","volume":"35","author":"Juremalm","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"2025032411204353600_r34","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1002\/eji.200535564","article-title":"CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli","volume":"36","author":"Tsunemi","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"2025032411204353600_r35","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.4049\/jimmunol.175.12.8320","article-title":"Topical superantigen exposure induces epidermal accumulation of CD8+ T cells, a mixed Th1\/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis","volume":"175","author":"Savinko","year":"2005","journal-title":"J. Immunol."},{"key":"2025032411204353600_r36","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.4049\/jimmunol.133.5.2397","article-title":"Delayed-type hypersensitivity is mediated by a sequence of two different T cell activities","volume":"133","author":"Van Loveren","year":"1984","journal-title":"J. Immunol."},{"key":"2025032411204353600_r37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1398-9995.2007.01386.x","article-title":"The role of innate immunity in asthma: leads and lessons from mouse models","volume":"62","author":"Schr\u00f6der","year":"2007","journal-title":"Allergy"},{"key":"2025032411204353600_r38","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/eji.200323830","article-title":"Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells","volume":"33","author":"Varadaradjalou","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025032411204353600_r39","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1172\/JCI0214704","article-title":"Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity","volume":"109","author":"Supajatura","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025032411204353600_r40","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.170.4.1625","article-title":"Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells","volume":"170","author":"McCurdy","year":"2003","journal-title":"J. Immunol."},{"key":"2025032411204353600_r41","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood-2005-06-2271","article-title":"Fc\u03b5R1 and Toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells","volume":"107","author":"Qiao","year":"2006","journal-title":"Blood"},{"key":"2025032411204353600_r42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpara.2003.10.004","article-title":"Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution","volume":"34","author":"Casiraghi","year":"2004","journal-title":"Int. J. Parasitol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/8\/4845\/61695712\/1000612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/8\/4845\/61695712\/1000612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T14:46:11Z","timestamp":1743173171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/186\/8\/4845\/7990092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1000612","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,4]]},"published":{"date-parts":[[2011,4]]}}}