{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:03:19Z","timestamp":1791129799057,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Memory\/effector T cells traffic efficiently through extralymphoid tissues, entering from the blood and leaving via the afferent lymph. During inflammation, T cell traffic into the affected tissue dramatically increases; however, the dynamics and mechanisms of T cell exit from inflamed tissues are poorly characterized. In this study, we show, using both a mouse and a sheep model, that large numbers of lymphocytes leave the chronically inflamed skin. Many T cells capable of producing IFN-\u03b3 and IL-17 also entered the draining afferent lymph, demonstrating that memory\/effector T cells egress from sites of inflammation. Whereas efficient egress from acutely inflamed skin required lymphocyte-expressed CCR7, chronic inflammation promoted significant CCR7-independent exit as well. Lymphocyte exit at late time points of inflammation was sensitive to pertussis toxin but was only partially affected by the drug FTY720, implying the contribution of alternative chemoattractant receptors other than spingosine 1-phosphate receptor 1. Our data show that CCR7 is an important receptor for lymphocyte egress from both resting and inflamed extralymphoid tissues, but that alternative exit receptors come into play during chronic inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1000676","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T23:32:20Z","timestamp":1284161540000},"page":"4873-4882","source":"Crossref","is-referenced-by-count":83,"title":["Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements during the Course of Inflammation"],"prefix":"10.1093","volume":"185","author":[{"given":"Meghan N","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R","family":"Fintushel","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Jennrich","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skye A","family":"Geherin","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene C","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford University , Stanford, CA 94305"},{"name":"Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun F","family":"Debes","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"key":"2025032412002504100_r1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.smim.2003.08.005","article-title":"Targeting T cell responses by selective chemokine receptor expression","volume":"15","author":"Campbell","year":"2003","journal-title":"Semin. 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