{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:39:44Z","timestamp":1790174384855,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymphotoxin \u03b2-receptor (LT\u03b2R) and TNF receptor-1 (TNFR1) are important for the development of secondary lymphoid organs during embryonic life. The significance of LT\u03b2R and TNFR1 for the formation of lymphoid tissue during adult life is not well understood. Immunohistochemistry, morphometry, flow cytometry, and laser microdissection were used to compare wild-type, LT\u03b2R\u2212\/\u2212, TNFR1\u2212\/\u2212 spleens with splenic tissue that has been newly formed 8 wk after avascular implantation into adult mice. During ontogeny, LT\u03b2R is sufficient to induce formation of the marginal zone, similar-sized T and B cell zones, and a mixed T\/B cell zone that completely surrounded the T cell zone. Strikingly, in adult mice, the formation of splenic compartments required both LT\u03b2R and TNFR1 expression, demonstrating that the molecular requirements for lymphoid tissue formation are different during embryonic and adult life. Thus, interfering with the TNFR1 pathway offers the possibility to selectively block the formation of ectopic lymphoid tissue and at the same time to spare secondary lymphoid organs such as spleen and lymph nodes. This opens a new perspective for the treatment of autoimmune and inflammatory diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1000740","type":"journal-article","created":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T01:45:22Z","timestamp":1293500722000},"page":"1486-1494","source":"Crossref","is-referenced-by-count":15,"title":["TNF Receptor-1 Is Required for the Formation of Splenic Compartments during Adult, but Not Embryonic Life"],"prefix":"10.1093","volume":"186","author":[{"given":"Novica M","family":"Mili\u0107evi\u0107","sequence":"first","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, University of Beograd , 11000 Beograd ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karola","family":"Klaperski","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Nohroudi","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]},{"name":"Department I of Anatomy, University of Cologne , 50931 Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u017divana","family":"Mili\u0107evi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology, Faculty of Medicine, University of Beograd , 11000 Beograd ,","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Bieber","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babett","family":"Baraniec","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Blessenohl","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kalies","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl F","family":"Ware","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Sandford|Burnham Medical Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Westermann","sequence":"additional","affiliation":[{"name":"Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"2025032411031759000_r1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nri2414","article-title":"Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence","volume":"8","author":"Junt","year":"2008","journal-title":"Nat. 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