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In this study, we assessed the role of IL-7, IL-15, and their common signal transducer, STAT5, in maintaining effector CD4+ and CD8+ T cell responses. Following viral infection, IL-15 was required to maintain a subpopulation of effector CD8+ T cells expressing high levels of killer cell lectin-like receptor subfamily G, member 1 (KLRG1), and lower levels of CD127, whereas IL-7 and IL-15 acted together to maintain KLRG1lowCD127high CD8+ effector T cells. In contrast, effector CD4+ T cell numbers were not affected by the individual or combined loss of IL-15 and IL-7. Both IL-7 and IL-15 drove phosphorylation of STAT5 within effector CD4+ and CD8+ T cells. When STAT5 was deleted during the course of infection, both KLRG1highCD127low and KLRG1lowCD127high CD8+ T cells were lost, although effector CD4+ T cell populations were maintained. Furthermore, STAT5 was required to maintain expression of Bcl-2 in effector CD8+, but not CD4+, T cells. Finally, IL-7 and IL-15 required STAT5 to induce Bcl-2 expression and to maintain effector CD8+ T cells. Together, these data demonstrate that IL-7 and IL-15 signaling converge on STAT5 to maintain effector CD8+ T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1000842","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T22:27:24Z","timestamp":1279578444000},"page":"2116-2124","source":"Crossref","is-referenced-by-count":116,"title":["STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses"],"prefix":"10.1093","volume":"185","author":[{"given":"Pulak","family":"Tripathi","sequence":"first","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Kurtulus","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Wojciechowski","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Sholl","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Hoebe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"},{"name":"Division of Molecular Immunology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne C","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Immunology, University of Cincinnati , Cincinnati, OH 45229"},{"name":"Research Service, Cincinnati Veterans Affairs Medical Center , Cincinnati, OH 45220"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"},{"name":"Division of Immunology, University of Cincinnati , Cincinnati, OH 45229"},{"name":"Research Service, Cincinnati Veterans Affairs Medical Center , Cincinnati, OH 45220"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Leighton","family":"Grimes","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Hildeman","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"2025032411483098600_r1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.smim.2009.02.002","article-title":"Surviving the crash: transitioning from effector to memory CD8+ T cell","volume":"21","author":"D\u2019Cruz","year":"2009","journal-title":"Semin. 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