{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:04:29Z","timestamp":1791079469338,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pseudomonas aeruginosa is a major cause of blindness and visual impairment in the United States and worldwide. Using a murine model of keratitis in which abraded corneas are infected with P. aeruginosa parent and \u0394fliC (aflagellar) strains 19660 and PAO1, we found that F4\/80+ macrophages were the predominant cell type in the cornea expressing TLR2, TLR4, and TLR5. Depletion of macrophages and dendritic cells using transgenic Mafia mice, in which Fas ligand is selectively activated in these cells, resulted in diminished cytokine production and cellular infiltration to the corneal stroma and unimpaired bacterial growth. TLR4\u2212\/\u2212 mice showed a similar phenotype postinfection with \u0394fliC strains, whereas TLR4\/5\u2212\/\u2212 mice were susceptible to corneal infection with parent strains. Bone marrow-derived macrophages stimulated with \u0394fliC bacteria induced Toll\/IL-1R intracellular domain (TIR)-containing adaptor inducing IFN-\u03b2 (TRIF)-dependent phosphorylation of IFN regulatory factor 3 in addition to TIR-containing adaptor protein\/MyD88-dependent phosphorylation of I\u03baB and nuclear translocation of the p65 subunit of NF\u03baB. Furthermore, TRIF\u2212\/\u2212 mice showed a similar phenotype as TLR4\u2212\/\u2212 mice in regulating only \u0394fliC bacteria, whereas MyD88\u2212\/\u2212 mice were unable to clear parent or \u0394fliC bacteria. Finally, IL-1R1\u2212\/\u2212 and IL-1\u03b1\/\u03b2\u2212\/\u2212 mice were highly susceptible to infection. Taken together, these findings indicate that P. aeruginosa activates TLR4\/5 on resident corneal macrophages, which signal through TRIF and TIR-containing adaptor protein\/MyD88 pathways, leading to NF-\u03baB translocation to the nucleus, transcription of CXCL1 and other CXC chemokines, recruitment of neutrophils to the corneal stroma, and subsequent bacterial killing and tissue damage. IL-1\u03b1 and IL-1\u03b2 are also produced, which activate an IL-1R1\/MyD88-positive feedback loop in macrophages and IL-1R on other resident cells in the cornea.<\/jats:p>","DOI":"10.4049\/jimmunol.1000874","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T02:42:49Z","timestamp":1284000169000},"page":"4272-4283","source":"Crossref","is-referenced-by-count":124,"title":["TLR4 and TLR5 on Corneal Macrophages Regulate <i>Pseudomonas aeruginosa<\/i> Keratitis by Signaling through MyD88-Dependent and -Independent Pathways"],"prefix":"10.1093","volume":"185","author":[{"given":"Yan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mausita","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"},{"name":"Department of Pathology, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanhita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raniyah T","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey L","family":"Shive","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M","family":"Stopford","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Rietsch","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, OH 44106"},{"name":"Department of Pathology, Case Western Reserve University , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"2025032411564690200_r1","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1099\/jmm.0.2008\/003723-0","article-title":"Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis","volume":"57","author":"Choy","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"2025032411564690200_r2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/ICO.0b013e318156caf2","article-title":"Risk factors and causative organisms in microbial keratitis","volume":"27","author":"Green","year":"2008","journal-title":"Cornea"},{"key":"2025032411564690200_r3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2147\/OPTH.S3249","article-title":"The clinical and cellular basis of contact lens-related corneal infections: a review","volume":"2","author":"Robertson","year":"2008","journal-title":"Clin. Ophthalmol."},{"key":"2025032411564690200_r4","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1167\/iovs.09-4593","article-title":"The impact of inoculation parameters on the pathogenesis of contact lens-related infectious keratitis","volume":"51","author":"Tam","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r5","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1167\/iovs.02-1302","article-title":"Contribution of ExsA-regulated factors to corneal infection by cytotoxic and invasive Pseudomonas aeruginosa in a murine scarification model","volume":"44","author":"Lee","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r6","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1167\/iovs.03-0229","article-title":"Role of Pseudomonas aeruginosa ExsA in penetration through corneal epithelium in a novel in vivo model","volume":"44","author":"Lee","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.exer.2007.08.015","article-title":"Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal disease severity","volume":"85","author":"Tam","year":"2007","journal-title":"Exp. Eye Res."},{"key":"2025032411564690200_r8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1167\/iovs.04-1077","article-title":"Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation","volume":"46","author":"Johnson","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r9","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1074\/jbc.M707264200","article-title":"MyD88 functions as a negative regulator of TLR3\/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase","volume":"283","author":"Johnson","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025032411564690200_r10","first-page":"2278","article-title":"Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and Toll-like receptor 4","volume":"43","author":"Khatri","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cyto.2008.07.010","article-title":"Signalling adaptors used by Toll-like receptors: an update","volume":"43","author":"Kenny","year":"2008","journal-title":"Cytokine"},{"key":"2025032411564690200_r12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1542-0124(12)70279-3","article-title":"Toll-like receptors at the ocular surface","volume":"6","author":"Pearlman","year":"2008","journal-title":"Ocul. Surf."},{"key":"2025032411564690200_r13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1167\/iovs.05-0956","article-title":"Toll-like receptors and the eye","volume":"47","author":"Yu","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r14","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1167\/iovs.03-0219","article-title":"Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin","volume":"44","author":"Zhang","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r15","first-page":"2867","article-title":"The expression of functional LPS receptor proteins CD14 and Toll-like receptor 4 in human corneal cells","volume":"42","author":"Song","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r16","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.4049\/jimmunol.173.5.3337","article-title":"Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium","volume":"173","author":"Ueta","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411564690200_r17","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1189\/jlb.1107783","article-title":"c-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation","volume":"83","author":"Adhikary","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"2025032411564690200_r18","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.4049\/jimmunol.0803505","article-title":"Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide\/TLR4-induced corneal inflammation","volume":"182","author":"Chinnery","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411564690200_r19","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1080\/02713689808951250","article-title":"Different strains of Pseudomonas aeruginosa isolated from ocular infections or inflammation display distinct corneal pathologies in an animal model","volume":"17","author":"Cole","year":"1998","journal-title":"Curr. Eye Res."},{"key":"2025032411564690200_r20","doi-asserted-by":"crossref","first-page":"8006","DOI":"10.1073\/pnas.0503005102","article-title":"ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa","volume":"102","author":"Rietsch","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411564690200_r21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-1119(96)00674-9","article-title":"Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest","volume":"186","author":"Warrens","year":"1997","journal-title":"Gene"},{"key":"2025032411564690200_r22","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1189\/jlb.0903442","article-title":"Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene","volume":"75","author":"Burnett","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2025032411564690200_r23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jss.2005.08.026","article-title":"Development of peritoneal adhesions in macrophage depleted mice","volume":"131","author":"Burnett","year":"2006","journal-title":"J. Surg. Res."},{"key":"2025032411564690200_r24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1167\/iovs.04-0741","article-title":"Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis","volume":"47","author":"Carlson","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r25","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1167\/iovs.08-2628","article-title":"Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564)","volume":"50","author":"Sun","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r26","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1189\/jlb.0806502","article-title":"CXCL1\/KC and CXCL5\/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis","volume":"81","author":"Lin","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032411564690200_r27","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2007.08.002","article-title":"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"key":"2025032411564690200_r28","doi-asserted-by":"crossref","first-page":"e7259","DOI":"10.1371\/journal.pone.0007259","article-title":"Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells","volume":"4","author":"Raoust","year":"2009","journal-title":"PLoS One"},{"key":"2025032411564690200_r29","doi-asserted-by":"crossref","first-page":"L312","DOI":"10.1152\/ajplung.00250.2006","article-title":"Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa","volume":"292","author":"Skerrett","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2025032411564690200_r30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"O\u2019Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411564690200_r31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025032411564690200_r32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/35092578","article-title":"Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction","volume":"413","author":"Fitzgerald","year":"2001","journal-title":"Nature"},{"key":"2025032411564690200_r33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01180","article-title":"The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors","volume":"420","author":"Horng","year":"2002","journal-title":"Nature"},{"key":"2025032411564690200_r34","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni0901-835","article-title":"TIRAP: an adapter molecule in the Toll signaling pathway","volume":"2","author":"Horng","year":"2001","journal-title":"Nat. Immunol."},{"key":"2025032411564690200_r35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physiolgenomics.00128.2004","article-title":"The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades","volume":"19","author":"Bj\u00f6rkbacka","year":"2004","journal-title":"Physiol. Genomics"},{"key":"2025032411564690200_r36","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1084\/jem.20031023","article-title":"LPS-TLR4 signaling to IRF-3\/7 and NF-\u03baB involves the Toll adapters TRAM and TRIF","volume":"198","author":"Fitzgerald","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032411564690200_r37","first-page":"2264","article-title":"Identification of a novel macrophage population in the normal mouse corneal stroma","volume":"43","author":"Brissette-Storkus","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r38","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1167\/iovs.06-0746","article-title":"The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium","volume":"48","author":"Chinnery","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1189\/jlb.1102544","article-title":"Corneal immunity is mediated by heterogeneous population of antigen-presenting cells","volume":"74","author":"Hamrah","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2025032411564690200_r40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1634\/stemcells.2004-0291","article-title":"CD34+ corneal stromal cells are bone marrow-derived and express hemopoietic stem cell markers","volume":"23","author":"Sosnov\u00e1","year":"2005","journal-title":"Stem Cells"},{"key":"2025032411564690200_r41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1167\/iovs.04-1154","article-title":"Characterization and distribution of bone marrow-derived cells in mouse cornea","volume":"46","author":"Nakamura","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411564690200_r43","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1167\/iovs.06-0537","article-title":"TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis","volume":"47","author":"Huang","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r44","first-page":"805","article-title":"Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive","volume":"41","author":"Hazlett","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r45","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.4049\/jimmunol.170.10.5219","article-title":"Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB\/c mice","volume":"170","author":"McClellan","year":"2003","journal-title":"J. Immunol."},{"key":"2025032411564690200_r46","doi-asserted-by":"crossref","first-page":"12487","DOI":"10.1073\/pnas.0605200103","article-title":"Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria","volume":"103","author":"Feuillet","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411564690200_r47","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4049\/jimmunol.181.1.586","article-title":"Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin","volume":"181","author":"Ramphal","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411564690200_r48","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1165\/rcmb.2005-0199OC","article-title":"An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia","volume":"33","author":"Hajjar","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025032411564690200_r49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.177.1.538","article-title":"Toll\/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa","volume":"177","author":"Jeyaseelan","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411564690200_r50","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.4049\/jimmunol.178.5.3170","article-title":"A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-\u03b2 in the host response to Pseudomonas aeruginosa lung infection in mice","volume":"178","author":"Power","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411564690200_r51","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.4049\/jimmunol.175.11.7484","article-title":"Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli","volume":"175","author":"Jeyaseelan","year":"2005","journal-title":"J. Immunol."},{"key":"2025032411564690200_r52","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.4049\/jimmunol.0901033","article-title":"Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection","volume":"183","author":"Cai","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411564690200_r53","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.4049\/jimmunol.178.5.3153","article-title":"Toll\/IL-1 receptor domain-containing adaptor inducing IFN-\u03b2 (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia","volume":"178","author":"Jeyaseelan","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411564690200_r54","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2006.03.047","article-title":"Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling","volume":"125","author":"Kagan","year":"2006","journal-title":"Cell"},{"key":"2025032411564690200_r55","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.4049\/jimmunol.164.12.6576","article-title":"Prolonged elevation of IL-1 in Pseudomonas aeruginosa ocular infection regulates macrophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence, and corneal perforation","volume":"164","author":"Rudner","year":"2000","journal-title":"J. Immunol."},{"key":"2025032411564690200_r56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/02713680490516710","article-title":"Regulation of Pseudomonas aeruginosa corneal infection in IL-1\u03b2 converting enzyme (ICE, caspase-1) deficient mice","volume":"29","author":"Thakur","year":"2004","journal-title":"Curr. Eye Res."},{"key":"2025032411564690200_r57","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/eji.200737532","article-title":"Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation","volume":"37","author":"Franchi","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025032411564690200_r58","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of Pseudomonas aeruginosa mediated by the IPAF\/NLRC4 inflammasome","volume":"204","author":"Sutterwala","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025032411564690200_r59","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.182.3.1609","article-title":"\u03b2-Defensin-2 promotes resistance against infection with P. aeruginosa","volume":"182","author":"Wu","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411564690200_r60","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/02713680701446653","article-title":"Ocular surface expression and in vitro activity of antimicrobial peptides","volume":"32","author":"Huang","year":"2007","journal-title":"Curr. Eye Res."},{"key":"2025032411564690200_r61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/IAI.01232-07","article-title":"Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis","volume":"76","author":"Kumar","year":"2008","journal-title":"Infect. Immun."},{"key":"2025032411564690200_r62","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1167\/iovs.07-0473","article-title":"Modulation of corneal epithelial innate immune response to Pseudomonas infection by flagellin pretreatment","volume":"48","author":"Kumar","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r63","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1167\/iovs.07-0993","article-title":"Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis","volume":"49","author":"Zaidi","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2025032411564690200_r64","doi-asserted-by":"crossref","first-page":"e1000826","DOI":"10.1371\/journal.ppat.1000826","article-title":"Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis","volume":"6","author":"Gadjeva","year":"2010","journal-title":"PLoS Pathog."},{"key":"2025032411564690200_r65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2003.10.002","article-title":"Corneal response to Pseudomonas aeruginosa infection","volume":"23","author":"Hazlett","year":"2004","journal-title":"Prog. Retin. Eye Res."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/7\/4272\/61652882\/1000874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/7\/4272\/61652882\/1000874.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:51:30Z","timestamp":1743209490000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/185\/7\/4272\/7984559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1000874","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,10]]},"published":{"date-parts":[[2010,10,1]]}}}