{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:40:07Z","timestamp":1791189607009,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rift Valley fever (RVF) is an arthropod-borne viral disease repeatedly reported in many African countries and, more recently, in Saudi Arabia and Yemen. RVF virus (RVFV) primarily infects domesticated ruminants, resulting in miscarriage in pregnant females and death for newborns and young animals. It also has the ability to infect humans, causing a feverish syndrome, meningoencephalitis, or hemorrhagic fever. The various outcomes of RVFV infection in animals and humans argue for the existence of host genetic determinants controlling the disease. We investigated the susceptibility of inbred mouse strains to infection with the virulent RVFV ZH548 strain. Compared with classical BALB\/cByJ mice, wild-derived Mus m. musculus MBT\/Pas mice exhibited earlier and greater viremia and died sooner, a result in sharp contrast with their resistance to infection with West Nile virus and influenza A. Infection of mouse embryonic fibroblasts (MEFs) from MBT\/Pas mice with RVFV also resulted in higher viral production. Microarray and quantitative RT-PCR experiments showed that BALB\/cByJ MEFs displayed a significant activation of the type I IFN pathway. In contrast, MBT\/Pas MEFs elicited a delayed and partial type I IFN response to RVFV infection. RNA interference-mediated inhibition of genes that were not induced by RVFV in MBT\/Pas MEFs increased viral production in BALB\/cByJ MEFs, thus demonstrating their functional importance in limiting viral replication. We conclude that the failure of MBT\/Pas murine strain to induce, in due course, a complete innate immune response is instrumental in the selective susceptibility to RVF.<\/jats:p>","DOI":"10.4049\/jimmunol.1000949","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:52:13Z","timestamp":1286844733000},"page":"6146-6156","source":"Crossref","is-referenced-by-count":67,"title":["A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever"],"prefix":"10.1093","volume":"185","author":[{"given":"T\u00e2nia Zaverucha","family":"do Valle","sequence":"first","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Fonctionnelle de la Souris , Paris ,","place":["France"]},{"name":"Unit\u00e9 de Recherche Associ\u00e9e 2578, Centre National de la Recherche Scientifique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Billecocq","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Mol\u00e9culaire des Bunyavirus, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Guillemot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Fonctionnelle de la Souris , Paris ,","place":["France"]},{"name":"Unit\u00e9 de Recherche Associ\u00e9e 2578, Centre National de la Recherche Scientifique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Alberts","sequence":"additional","affiliation":[{"name":"Department of Infection Genetics, Helmholtz Centre for Infection Research , Braunschweig ,","place":["Germany"]},{"name":"University of Veterinary Medicine , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Gommet","sequence":"additional","affiliation":[{"name":"Animalerie Centrale, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Geffers","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Array Facility, Helmholtz Centre for Infection Research , Braunschweig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schughart","sequence":"additional","affiliation":[{"name":"Department of Infection Genetics, Helmholtz Centre for Infection Research , Braunschweig ,","place":["Germany"]},{"name":"University of Veterinary Medicine , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bouloy","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Mol\u00e9culaire des Bunyavirus, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Montagutelli","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Fonctionnelle de la Souris , Paris ,","place":["France"]},{"name":"Unit\u00e9 de Recherche Associ\u00e9e 2578, Centre National de la Recherche Scientifique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Panthier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9n\u00e9tique Fonctionnelle de la Souris , Paris ,","place":["France"]},{"name":"Unit\u00e9 de Recherche Associ\u00e9e 2578, Centre National de la Recherche Scientifique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"2025032412084932100_r1","first-page":"613","article-title":"Rift Valley fever","volume":"23","author":"Gerdes","year":"2004","journal-title":"Rev. - Off. Int. Epizoot."},{"key":"2025032412084932100_r2","first-page":"p. 45","volume-title":"FAO Animal Health Manual.","author":"Food and Agriculture Organization","year":"2003"},{"key":"2025032412084932100_r3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/156652405774962263","article-title":"Rift Valley fever virus","volume":"5","author":"Flick","year":"2005","journal-title":"Curr. Mol. Med."},{"key":"2025032412084932100_r4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/0042-6822(91)90087-R","article-title":"Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses","volume":"180","author":"Giorgi","year":"1991","journal-title":"Virology"},{"key":"2025032412084932100_r5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4269\/ajtmh.1995.53.405","article-title":"Characterization of clone 13, a naturally attenuated avirulent isolate of Rift Valley fever virus, which is altered in the small segment","volume":"53","author":"Muller","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2025032412084932100_r6","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1371\/journal.ppat.0040013","article-title":"A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells","volume":"4","author":"Le May","year":"2008","journal-title":"PLoS Pathog."},{"key":"2025032412084932100_r7","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/JVI.02148-08","article-title":"NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase","volume":"83","author":"Habjan","year":"2009","journal-title":"J. Virol."},{"key":"2025032412084932100_r8","doi-asserted-by":"crossref","first-page":"e1000287","DOI":"10.1371\/journal.ppat.1000287","article-title":"Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation","volume":"5","author":"Ikegami","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025032412084932100_r9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(04)00132-1","article-title":"TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus","volume":"116","author":"Le May","year":"2004","journal-title":"Cell"},{"key":"2025032412084932100_r10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4269\/ajtmh.1991.44.475","article-title":"Infection of inbred rat strains with Rift Valley fever virus: development of a congenic resistant strain and observations on age-dependence of resistance","volume":"44","author":"Anderson","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2025032412084932100_r11","first-page":"21","article-title":"Pathogenesis of Rift Valley Fever","volume":"3","author":"Peters","year":"1981","journal-title":"Contrib. Epidemiol. Biostat."},{"key":"2025032412084932100_r12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jmv.1890100107","article-title":"Inbred rat strains mimic the disparate human response to Rift Valley fever virus infection","volume":"10","author":"Peters","year":"1982","journal-title":"J. Med. Virol."},{"key":"2025032412084932100_r13","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1099\/0022-1317-81-11-2683","article-title":"Resistance to Rift Valley fever virus in Rattus norvegicus: genetic variability within certain \u2018inbred\u2019 strains","volume":"81","author":"Ritter","year":"2000","journal-title":"J. Gen. Virol."},{"key":"2025032412084932100_r14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0168-9525(02)00007-0","article-title":"Wild mice: an ever-increasing contribution to a popular mammalian model","volume":"19","author":"Gu\u00e9net","year":"2003","journal-title":"Trends Genet."},{"key":"2025032412084932100_r15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/71641","article-title":"Genealogies of mouse inbred strains","volume":"24","author":"Beck","year":"2000","journal-title":"Nat. Genet."},{"key":"2025032412084932100_r16","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng2087","article-title":"On the subspecific origin of the laboratory mouse","volume":"39","author":"Yang","year":"2007","journal-title":"Nat. Genet."},{"key":"2025032412084932100_r17","first-page":"1577","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Bonhomme","year":"1996"},{"key":"2025032412084932100_r18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/dbio.1998.9160","article-title":"Germ cell development in the XXY mouse: evidence that X chromosome reactivation is independent of sexual differentiation","volume":"207","author":"Mroz","year":"1999","journal-title":"Dev. Biol."},{"key":"2025032412084932100_r19","first-page":"123","article-title":"Rift Valley fever outbreak in Egypt. October\u2014December 1977","volume":"53","author":"El-Akkad","year":"1978","journal-title":"J. Egypt. Public Health Assoc."},{"key":"2025032412084932100_r20","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1128\/JVI.02095-06","article-title":"Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry","volume":"81","author":"Bird","year":"2007","journal-title":"J. Virol."},{"key":"2025032412084932100_r21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-422X-1-9","article-title":"The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World","volume":"1","author":"Lucas","year":"2004","journal-title":"Virol. J."},{"key":"2025032412084932100_r22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.micinf.2010.01.008","article-title":"Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection","volume":"12","author":"lberts","year":"2010","journal-title":"Microbes Infect"},{"key":"2025032412084932100_r23","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.4049\/jimmunol.120.4.1164","article-title":"The analysis of the monoclonal immune response to influenza virus. III. The relationship between stimulation of virus-primed precursor B cells by heterologous viruses and reactivity of secreted antibodies","volume":"120","author":"Gerhard","year":"1978","journal-title":"J. Immunol."},{"key":"2025032412084932100_r24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2025032412084932100_r25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.98.1.31","article-title":"Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection","volume":"98","author":"Li","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412084932100_r26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2025032412084932100_r27","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/bmj.328.7447.1073","article-title":"The logrank test","volume":"328","author":"Bland","year":"2004","journal-title":"BMJ"},{"key":"2025032412084932100_r28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2025032412084932100_r29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1124\/jpet.110.167650","article-title":"Type I interferon receptor is a primary regulator of target-mediated drug disposition of interferon-beta in mice","volume":"334","author":"Abraham","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025032412084932100_r30","doi-asserted-by":"crossref","first-page":"11311","DOI":"10.1073\/pnas.172195399","article-title":"A nonsense mutation in the gene encoding 2\u2032-5\u2032-oligoadenylate synthetase\/L1 isoform is associated with West Nile virus susceptibility in laboratory mice","volume":"99","author":"Mashimo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412084932100_r31","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1128\/JVI.78.18.9798-9806.2004","article-title":"NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription","volume":"78","author":"Billecocq","year":"2004","journal-title":"J. Virol."},{"key":"2025032412084932100_r32","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.biochi.2007.03.006","article-title":"ISG20, an actor of the innate immune response","volume":"89","author":"Degols","year":"2007","journal-title":"Biochimie"},{"key":"2025032412084932100_r33","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1128\/JVI.76.11.5532-5539.2002","article-title":"Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes","volume":"76","author":"Grandvaux","year":"2002","journal-title":"J. Virol."},{"key":"2025032412084932100_r34","first-page":"85","article-title":"Innate resistance to flavivirus infections and the functions of 2\u2032-5\u2032 oligoadenylate synthetases","volume":"321","author":"Mashimo","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025032412084932100_r35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1128\/JVI.75.3.1371-1377.2001","article-title":"Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs","volume":"75","author":"Bouloy","year":"2001","journal-title":"J. Virol."},{"key":"2025032412084932100_r36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0166-3542(86)90024-0","article-title":"Prophylaxis of Rift Valley fever with antiviral drugs, immune serum, an interferon inducer, and a macrophage activator","volume":"6","author":"Peters","year":"1986","journal-title":"Antiviral Res."},{"key":"2025032412084932100_r37","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"Honda","year":"2005","journal-title":"Nature"},{"key":"2025032412084932100_r38","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1073\/pnas.0504754102","article-title":"Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways","volume":"102","author":"Zhao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412084932100_r39","first-page":"29","article-title":"ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation","volume":"52","author":"Lu","year":"2006","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"key":"2025032412084932100_r40","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1073\/pnas.0607038104","article-title":"IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses","volume":"104","author":"Lenschow","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412084932100_r41","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1128\/MCB.25.15.6338-6345.2005","article-title":"ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus","volume":"25","author":"Osiak","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2025032412084932100_r42","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/nar\/gkg427","article-title":"Characterization of the 2\u2032-5\u2032-oligoadenylate synthetase ubiquitin-like family","volume":"31","author":"Eskildsen","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2025032412084932100_r43","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1073\/pnas.142287799","article-title":"Positional cloning of the murine flavivirus resistance gene","volume":"99","author":"Perelygin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412084932100_r44","doi-asserted-by":"crossref","first-page":"e1000321","DOI":"10.1371\/journal.ppat.1000321","article-title":"Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man","volume":"5","author":"Lim","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025032412084932100_r45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virol.2008.10.021","article-title":"The large form of human 2\u2032,5\u2032-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus","volume":"384","author":"Br\u00e9hin","year":"2009","journal-title":"Virology"},{"key":"2025032412084932100_r46","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/JVI.01305-07","article-title":"Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1","volume":"82","author":"Fredericksen","year":"2008","journal-title":"J. Virol."},{"key":"2025032412084932100_r47","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/icb.1957.61","article-title":"Rift Valley fever virus in mice. VI. Histological changes in the liver in relation to virus multiplication","volume":"35","author":"Mims","year":"1957","journal-title":"Aust. J. Exp. Biol. Med. Sci."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/10\/6146\/62469146\/1000949.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/10\/6146\/62469146\/1000949.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T02:39:19Z","timestamp":1743215959000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/185\/10\/6146\/7981970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1000949","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,11]]},"published":{"date-parts":[[2010,11]]}}}