{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:05:48Z","timestamp":1790849148645,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Viral infections often induce robust T cell responses that are long-lived and protective. However, it is unclear to what degree systemic versus mucosal infection influences the generation of effector and memory T cells. In this study, we characterized memory CD8+ T cells generated after respiratory influenza virus infection and compared the phenotypic and functional qualities of these cells with memory T cells generated after systemic infection with lymphocytic choriomeningitis virus (LCMV). Using a recombinant influenza virus expressing the LCMV gp33\u201341 epitope and TCR transgenic CD8+ T cells with a fixed TCR, we compared responses to the same Ag delivered by mucosal or systemic viral infection. Memory cells generated postinfection with either virus showed only a few phenotypic differences. Yet, influenza memory T cells produced lower amounts of effector cytokines upon restimulation and displayed reduced proliferation compared with LCMV-induced memory cells. Strikingly, we observed reduced expansion of spleen- and, in particular, lung-derived influenza memory cells after recall in vivo, which correlated with reduced early protection from secondary infection. These findings suggest that qualitatively different memory CD8+ T cells are generated after respiratory or systemic virus infections.<\/jats:p>","DOI":"10.4049\/jimmunol.1001142","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T22:11:44Z","timestamp":1279318304000},"page":"2182-2190","source":"Crossref","is-referenced-by-count":44,"title":["Qualitatively Different Memory CD8+ T Cells Are Generated after Lymphocytic Choriomeningitis Virus and Influenza Virus Infections"],"prefix":"10.1093","volume":"185","author":[{"given":"Scott N","family":"Mueller","sequence":"first","affiliation":[{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Langley","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Li","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Microbiology, Mount Sinai School of Medicine , New York, NY 10029"},{"name":"Department of Medicine, Mount Sinai School of Medicine , New York, NY 10029"},{"name":"Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Webby","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"2025032411492248200_r1","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.4049\/jimmunol.174.9.5341","article-title":"Reducing the stimulation of CD8+ T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset","volume":"174","author":"van Faassen","year":"2005","journal-title":"J. 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