{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:35:16Z","timestamp":1790717716467,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent evidence demonstrating that exposure to rapamycin during viral infection increased the quantity and quality of Ag-specific T cells poses an intriguing paradox, because rapamycin is used in transplantation to dampen, rather than enhance, donor-reactive T cell responses. In this report, we compared the effects of rapamycin on the Ag-specific T cell response to a bacterial infection versus a transplant. Using a transgenic system in which the Ag and the responding T cell population were identical in both cases, we observed that treatment with rapamycin augmented the Ag-specific T cell response to a pathogen, whereas it failed to do so when the Ag was presented in the context of a transplant. These results suggest that the environment in which an Ag is presented alters the influence of rapamycin on Ag-specific T cell expansion and highlights a fundamental difference between Ag presented by an infectious agent as compared with an allograft.<\/jats:p>","DOI":"10.4049\/jimmunol.1001176","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T20:02:01Z","timestamp":1279137721000},"page":"2004-2008","source":"Crossref","is-referenced-by-count":103,"title":["Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses"],"prefix":"10.1093","volume":"185","author":[{"given":"Ivana R","family":"Ferrer","sequence":"first","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maylene E","family":"Wagener","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Robertson","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa P","family":"Turner","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Araki","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Emory Vaccine Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Microbiology and Immunology, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan D","family":"Kirk","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P","family":"Larsen","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy L","family":"Ford","sequence":"additional","affiliation":[{"name":"Emory Transplant Center, Emory University , Atlanta, GA 30322"},{"name":"Department of Surgery, Emory University , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"2025032411480573500_r1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nri2546","article-title":"Immunoregulatory functions of mTOR inhibition","volume":"9","author":"Thomson","year":"2009","journal-title":"Nat. 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