{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:29:15Z","timestamp":1764001755382,"version":"3.40.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-2 complexes have substantial effects on the cellular immune system, and this approach is being explored for therapeutic application in infection and cancer. However, the impact of such treatments on subsequent encounter with pathogens has not been investigated. In this study, we report that naive mice treated with a short course of IL-2 complexes show enhanced protection from newly encountered bacterial and viral infections. IL-2 complex treatment expands both the NK and CD8 memory cell pool, including a recently described population of preexisting memory-phenotype T cells responsive to previously unencountered foreign Ags. Surprisingly, prolonged IL-2 complex treatment decreased CD8 T cell function and protective immunity. These data reveal the impact of cytokine complex treatment on the primary response to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1001215","type":"journal-article","created":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T03:06:24Z","timestamp":1288407984000},"page":"6584-6590","source":"Crossref","is-referenced-by-count":34,"title":["IL-2 Complex Treatment Can Protect Naive Mice from Bacterial and Viral Infection"],"prefix":"10.1093","volume":"185","author":[{"given":"Sara E","family":"Hamilton","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology , Minneapolis, MN, 55454"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M","family":"Schenkel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology , Minneapolis, MN, 55454"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adovi D","family":"Akue","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology , Minneapolis, MN, 55454"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C","family":"Jameson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology , Minneapolis, MN, 55454"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"2025032412121636300_r1","first-page":"S76","article-title":"The future of interleukin-2: enhancing therapeutic anticancer vaccines","volume":"6","author":"Overwijk","year":"2000","journal-title":"Cancer J. Sci. Am."},{"key":"2025032412121636300_r2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nm866","article-title":"Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo","volume":"9","author":"Blattman","year":"2003","journal-title":"Nat. Med."},{"key":"2025032412121636300_r3","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1126\/science.1122927","article-title":"Selective stimulation of T cell subsets with antibody-cytokine immune complexes","volume":"311","author":"Boyman","year":"2006","journal-title":"Science"},{"key":"2025032412121636300_r4","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1073\/pnas.0805054105","article-title":"Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy","volume":"105","author":"Verdeil","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412121636300_r5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/intimm\/dxn036","article-title":"Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation","volume":"20","author":"Jin","year":"2008","journal-title":"Int. Immunol."},{"key":"2025032412121636300_r6","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.4049\/jimmunol.0900284","article-title":"In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy","volume":"183","author":"Tomala","year":"2009","journal-title":"J. Immunol."},{"key":"2025032412121636300_r7","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.4049\/jimmunol.0804175","article-title":"Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection","volume":"182","author":"Molloy","year":"2009","journal-title":"J. Immunol."},{"key":"2025032412121636300_r8","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1182\/blood-2008-06-160945","article-title":"IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response","volume":"112","author":"Rubinstein","year":"2008","journal-title":"Blood"},{"key":"2025032412121636300_r9","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.4049\/jimmunol.180.7.5118","article-title":"IL-2\/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8(+) T cell responses and increases the ratio of effector\/memory CD8(+) T cells to regulatory T cells","volume":"180","author":"Mostb\u00f6ck","year":"2008","journal-title":"J. Immunol."},{"key":"2025032412121636300_r10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.20081829","article-title":"The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion","volume":"206","author":"Haluszczak","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025032412121636300_r11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/ni1326","article-title":"The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells","volume":"7","author":"Hamilton","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025032412121636300_r12","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1084\/jem.20070543","article-title":"Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo","volume":"204","author":"Kamimura","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025032412121636300_r13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1084\/jem.191.2.335","article-title":"Critical role for CD8 in T cell receptor binding and activation by peptide\/major histocompatibility complex multimers","volume":"191","author":"Daniels","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032412121636300_r14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","article-title":"Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude","volume":"27","author":"Moon","year":"2007","journal-title":"Immunity"},{"key":"2025032412121636300_r15","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.166.5.3402","article-title":"Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection","volume":"166","author":"Pope","year":"2001","journal-title":"J. Immunol."},{"key":"2025032412121636300_r16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.18.1.275","article-title":"CD8+ T cell effector mechanisms in resistance to infection","volume":"18","author":"Harty","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"2025032412121636300_r17","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.4049\/jimmunol.165.7.3673","article-title":"CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo","volume":"165","author":"Assarsson","year":"2000","journal-title":"J. Immunol."},{"key":"2025032412121636300_r18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.coi.2009.01.010","article-title":"The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses","volume":"21","author":"Crawford","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"2025032412121636300_r19","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"Berg","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025032412121636300_r20","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.4049\/jimmunol.172.10.6265","article-title":"Cellular and humoral immunity against vaccinia virus infection of mice","volume":"172","author":"Xu","year":"2004","journal-title":"J. Immunol."},{"key":"2025032412121636300_r21","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.0600240103","article-title":"Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha","volume":"103","author":"Rubinstein","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032412121636300_r22","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.177.9.6072","article-title":"Combined IL-15\/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo","volume":"177","author":"Stoklasek","year":"2006","journal-title":"J. Immunol."},{"key":"2025032412121636300_r23","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.f.1774","article-title":"CD8+ T cell efficacy in vaccination and disease","volume":"14","author":"Appay","year":"2008","journal-title":"Nat. Med."},{"key":"2025032412121636300_r24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.it.2009.12.003","article-title":"Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV\/AIDS","volume":"31","author":"Ahlers","year":"2010","journal-title":"Trends Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/11\/6584\/61653289\/1001215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/11\/6584\/61653289\/1001215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T03:12:46Z","timestamp":1743217966000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/185\/11\/6584\/7984602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1001215","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2010,12]]},"published":{"date-parts":[[2010,12,1]]}}}