{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:04:00Z","timestamp":1760267040132,"version":"3.40.3"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Congenital heart block develops in fetuses of anti-Ro52 Ab-positive women. A recurrence rate of 20%, despite the persistence of maternal autoantibodies, indicates that there are additional, yet unidentified, factors critical for development of congenital heart block. In this study, we demonstrate that besides the maternal MHC controlling Ab specificity, fetal MHC-encoded genes influence fetal susceptibility to congenital heart block. Using MHC congenic rat strains, we show that heart block develops in rat pups of three strains carrying MHC haplotype RT1av1 (DA, PVG.AV1, and LEW.AV1) after maternal Ro52 immunization, but not in LEW rats (RT1l). Different anti-Ro52 Ab fine specificities were generated in RT1av1 versus RT1l animals. Maternal and fetal influence was determined in an F2 cross between LEW.AV1 and LEW strains, which revealed higher susceptibility in RT1l than RT1av1 pups once pathogenic Ro52 Abs were present. This was further confirmed in that RT1l pups more frequently developed heart block than RT1av1 pups after passive transfer of RT1av1 anti-Ro52 sera. Our findings show that generation of pathogenic Ro52 Abs is restricted by maternal MHC, whereas the fetal MHC locus regulates susceptibility and determines the fetal disease outcome in anti-Ro52\u2013positive pregnancies.<\/jats:p>","DOI":"10.4049\/jimmunol.1001396","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T03:05:34Z","timestamp":1281409534000},"page":"3574-3582","source":"Crossref","is-referenced-by-count":28,"title":["Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block"],"prefix":"10.1093","volume":"185","author":[{"given":"Linn S","family":"Strandberg","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelie","family":"Ambrosi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Jagodic","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijole","family":"Dzikaite","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Janson","sequence":"additional","affiliation":[{"name":"Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Khademi","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Salomonsson","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Ottosson","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klauninger","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"\u00c5d\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven-Erik","family":"Sonesson","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sunnerhagen","sequence":"additional","affiliation":[{"name":"Molecular Biotechnology, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien L","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Hertie Institute for Clinical Brain Research, University of T\u00fcbingen , T\u00fcbingen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Center for Neurological Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnane","family":"Achour","sequence":"additional","affiliation":[{"name":"Center for Infectious Medicine, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Winqvist","sequence":"additional","affiliation":[{"name":"Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Olsson","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Wahren-Herlenius","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, Karolinska Institutet , Stockholm"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"key":"2025032411544769400_r1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00403-008-0896-4","article-title":"The clinical spectrum of neonatal lupus","volume":"301","author":"Lee","year":"2009","journal-title":"Arch. Dermatol. Res."},{"key":"2025032411544769400_r2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1212\/WNL.38.1.138","article-title":"Neonatal myasthenia gravis: a new clinical and immunologic appraisal on 30 cases","volume":"38","author":"Morel","year":"1988","journal-title":"Neurology"},{"key":"2025032411544769400_r3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ecl.2009.07.002","article-title":"Congenital disorders of the thyroid: hypo\/hyper","volume":"38","author":"P\u00e9ter","year":"2009","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"2025032411544769400_r4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nm.1892","article-title":"Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus","volume":"15","author":"Lee","year":"2009","journal-title":"Nat. Med."},{"key":"2025032411544769400_r5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.coi.2006.09.012","article-title":"Specificity and effector mechanisms of autoantibodies in congenital heart block","volume":"18","author":"Wahren-Herlenius","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"2025032411544769400_r6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1046\/j.1365-3083.2001.00993.x","article-title":"Associations of MHC class II alleles in Norwegian primary Sj\u00f6gren\u2019s syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen","volume":"54","author":"Nakken","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"2025032411544769400_r7","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/art.11103","article-title":"In primary Sj\u00f6gren\u2019s syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response","volume":"48","author":"Gottenberg","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1056\/NEJM198501103120206","article-title":"Maternal connective tissue disease and congenital heart block: demonstration of immunoglobulin in cardiac tissue","volume":"312","author":"Litsey","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"2025032411544769400_r9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/art.11430","article-title":"Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage\/fibroblast crosstalk in the pathologic cascade leading to congenital heart block","volume":"50","author":"Clancy","year":"2004","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r10","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.161.11.5886","article-title":"Induction of antibodies reactive with SSA\/Ro-SSB\/La and development of congenital heart block in a murine model","volume":"161","author":"Miranda-Car\u00fas","year":"1998","journal-title":"J. Immunol."},{"key":"2025032411544769400_r11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1084\/jem.20041859","article-title":"Ro\/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block","volume":"201","author":"Salomonsson","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025032411544769400_r12","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/1529-0131(200108)44:8<1832::AID-ART320>3.0.CO;2-C","article-title":"Risk of congenital complete heart block in newborns of mothers with anti-Ro\/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women","volume":"44","author":"Brucato","year":"2001","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1067\/mpd.2003.233","article-title":"Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants born to mothers with anti-Ro autoantibodies","volume":"142","author":"Cimaz","year":"2003","journal-title":"J. Pediatr."},{"key":"2025032411544769400_r14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1191\/0961203303lu425xx","article-title":"Birth order, gender and recurrence rate in autoantibody-associated congenital heart block: implications for pathogenesis and family counseling","volume":"12","author":"Solomon","year":"2003","journal-title":"Lupus"},{"key":"2025032411544769400_r15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1191\/0961203306lu2309oa","article-title":"Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies","volume":"15","author":"Strandberg","year":"2006","journal-title":"Lupus"},{"key":"2025032411544769400_r16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/art.1780310601","article-title":"Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus","volume":"31","author":"Lockshin","year":"1988","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r17","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/art.1780350817","article-title":"Anti-Ro\/SS-A and anti-La\/SS-B autoantibody levels in relation to systemic lupus erythematosus disease activity and congenital heart block: a longitudinal study comprising two consecutive pregnancies in a patient with systemic lupus erythematosus","volume":"35","author":"Derksen","year":"1992","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r18","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1651-2227.2004.tb03022.x","article-title":"Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block","volume":"93","author":"Eronen","year":"2004","journal-title":"Acta Paediatr."},{"key":"2025032411544769400_r19","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/art.10232","article-title":"A serologic marker for fetal risk of congenital heart block","volume":"46","author":"Salomonsson","year":"2002","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r20","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.4049\/jimmunol.176.10.6277","article-title":"The Sjogren\u2019s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death","volume":"176","author":"Espinosa","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411544769400_r21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/1521-4141(200102)31:2<573::AID-IMMU573>3.0.CO;2-9","article-title":"Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor","volume":"31","author":"Eftekhari","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"2025032411544769400_r22","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1084\/jem.20020390","article-title":"Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand","volume":"196","author":"Munder","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032411544769400_r23","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.4049\/jimmunol.173.4.2792","article-title":"MHC class II isotype- and allele-specific attenuation of experimental autoimmune encephalomyelitis","volume":"173","author":"de Graaf","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411544769400_r24","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1073\/pnas.030390097","article-title":"Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen","volume":"97","author":"Weissert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411544769400_r25","doi-asserted-by":"crossref","first-page":"D315","DOI":"10.1093\/nar\/gkj056","article-title":"The SWISS-MODEL Repository: new features and functionalities","volume":"34","author":"Kopp","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2025032411544769400_r26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneuroim.2005.05.004","article-title":"CDR3 sequence preference of TCRBV8S2+ T cells within the CNS does not reflect single amino acid dependent avidity expansion","volume":"166","author":"de Graaf","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"2025032411544769400_r27","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1093\/nar\/19.15.4293","article-title":"Simplified mammalian DNA isolation procedure","volume":"19","author":"Laird","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"2025032411544769400_r28","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ng.124","article-title":"SNP and haplotype mapping for genetic analysis in the rat","volume":"40","author":"STAR Consortium, K.","year":"2008","journal-title":"Nat. Genet."},{"key":"2025032411544769400_r29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ng0195-63","article-title":"A genetic linkage map of the laboratory rat, Rattus norvegicus","volume":"9","author":"Jacob","year":"1995","journal-title":"Nat. Genet."},{"key":"2025032411544769400_r30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1191\/096120399678847407","article-title":"Role of HLA in congenital heart block: susceptibility alleles in children","volume":"8","author":"Sir\u00e9n","year":"1999","journal-title":"Lupus"},{"key":"2025032411544769400_r31","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI3022","article-title":"MHC haplotype-dependent regulation of MOG-induced EAE in rats","volume":"102","author":"Weissert","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2025032411544769400_r32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1046\/j.1365-3083.1996.d01-354.x","article-title":"Susceptibility of DA rats to arthritis induced with adjuvant oil or rat collagen is determined by genes both within and outside the major histocompatibility complex","volume":"44","author":"Lorentzen","year":"1996","journal-title":"Scand. J. Immunol."},{"key":"2025032411544769400_r33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/art.1780360218","article-title":"Induction of autoimmune arthritis in rats by immunization with homologous rat type II collagen is restricted to the RT1av1 haplotype","volume":"36","author":"Griffiths","year":"1993","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r34","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.molimm.2005.04.013","article-title":"Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sj\u00f6gren\u2019s syndrome","volume":"43","author":"Ottosson","year":"2006","journal-title":"Mol. Immunol."},{"key":"2025032411544769400_r35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-4165(01)00212-4","article-title":"Leucine zipper domain of 52 kDa SS-A\/Ro promotes protein dimer formation and inhibits in vitro transcription activity","volume":"1568","author":"Wang","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"2025032411544769400_r36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.0300-9475.2005.01542.x","article-title":"Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein","volume":"61","author":"Ottosson","year":"2005","journal-title":"Scand. J. Immunol."},{"key":"2025032411544769400_r37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00210484","article-title":"Structural polymorphism of six rat RT1Ba genes","volume":"38","author":"Holmdahl","year":"1993","journal-title":"Immunogenetics"},{"key":"2025032411544769400_r38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00251-004-0725-7","article-title":"Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles","volume":"56","author":"Ettinger","year":"2004","journal-title":"Immunogenetics"},{"key":"2025032411544769400_r39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0022-2836(02)01437-7","article-title":"Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif","volume":"326","author":"Zhu","year":"2003","journal-title":"J. Mol. Biol."},{"key":"2025032411544769400_r40","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1021\/jm000034h","article-title":"Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules: design, structure-activity relationships, and x-ray crystal structures","volume":"43","author":"Bolin","year":"2000","journal-title":"J. Med. Chem."},{"key":"2025032411544769400_r41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ni1502","article-title":"Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction \u2018codon.\u2019","volume":"8","author":"Feng","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025032411544769400_r42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri1805","article-title":"MHC class II proteins and disease: a structural perspective","volume":"6","author":"Jones","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411544769400_r43","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/ndt\/16.7.1374","article-title":"T cell receptor BV gene usage in interstitial cellular infiltrates in active Heymann nephritis","volume":"16","author":"Wu","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"2025032411544769400_r44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s10875-007-9157-0","article-title":"Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies","volume":"28","author":"Strandberg","year":"2008","journal-title":"J. Clin. Immunol."},{"key":"2025032411544769400_r45","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.4049\/jimmunol.167.12.7119","article-title":"T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells","volume":"167","author":"Forsthuber","year":"2001","journal-title":"J. Immunol."},{"key":"2025032411544769400_r46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/intimm\/13.3.257","article-title":"Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis","volume":"13","author":"Encinas","year":"2001","journal-title":"Int. Immunol."},{"key":"2025032411544769400_r47","doi-asserted-by":"crossref","first-page":"8024","DOI":"10.1073\/pnas.0600536103","article-title":"Evidence that the Y chromosome influences autoimmune disease in male and female mice","volume":"103","author":"Teuscher","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411544769400_r48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1191\/096120399678847399","article-title":"Role of HLA in congenital heart block: susceptibility alleles in mothers","volume":"8","author":"Sir\u00e9n","year":"1999","journal-title":"Lupus"},{"key":"2025032411544769400_r49","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/art.1780400532","article-title":"Neonatal lupus erythematosus: haplotypic analysis of HLA class II alleles in child\/mother pairs","volume":"40","author":"Miyagawa","year":"1997","journal-title":"Arthritis Rheum."},{"key":"2025032411544769400_r50","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1101\/gr.1987704","article-title":"The genomic sequence and comparative analysis of the rat major histocompatibility complex","volume":"14","author":"Hurt","year":"2004","journal-title":"Genome Res."},{"key":"2025032411544769400_r51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1056\/NEJM198609113151103","article-title":"Maternal antibodies against fetal cardiac antigens in congenital complete heart block","volume":"315","author":"Taylor","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"2025032411544769400_r52","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.4049\/jimmunol.171.6.3253","article-title":"Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block","volume":"171","author":"Clancy","year":"2003","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/6\/3574\/61612517\/1001396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/185\/6\/3574\/61612517\/1001396.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:31:40Z","timestamp":1743208300000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/185\/6\/3574\/7977848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,9,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1001396","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2010,9]]},"published":{"date-parts":[[2010,9]]}}}