{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:14:15Z","timestamp":1792613655406,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis is associated with the development of autoantibodies to citrullinated self-proteins. Citrullinated synovial proteins, which are generated via the actions of the protein arginine deiminases (PADs), are known to develop in the murine collagen-induced arthritis (CIA) model of inflammatory arthritis. Given these findings, we evaluated whether N-\u03b1-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide (Cl-amidine), a recently described pan-PAD inhibitor, could affect the development of arthritis and autoimmunity by treating mice in the CIA model with Cl-amidine on days 0\u201335. Cl-amidine treatment reduced total synovial and serum citrullination, decreased clinical disease activity by \u223c50%, and significantly decreased IgG2a anti-mouse type II collagen Abs. Additionally, histopathology scores and total complement C3 deposition were significantly lower in Cl-amidine\u2013treated mice compared with vehicle controls. Synovial microarray analyses demonstrated decreased IgG reactivity to several native and citrullinated epitopes compared with vehicle controls. Cl-amidine treatment had no ameliorative effect on collagen Ab-induced arthritis, suggesting its primary protective mechanism was not mediated through effector pathways. Reduced levels of citrullinated synovial proteins observed in mice treated with Cl-amidine are consistent with the notion that Cl-amidine derives its efficacy from its ability to inhibit the deiminating activity of PADs. In total, these results suggested that PADs are necessary participants in the autoimmune and subsequent inflammatory processes in CIA. Cl-amidine may represent a novel class of disease-modifying agents that modulate aberrant citrullination, and perhaps other immune processes, necessary for the development of inflammatory arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.1001620","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:35:21Z","timestamp":1298507721000},"page":"4396-4404","source":"Crossref","is-referenced-by-count":266,"title":["N-\u03b1-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-\n                    <scp>l<\/scp>\n                    -Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis"],"prefix":"10.1093","volume":"186","author":[{"given":"Van C","family":"Willis","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M","family":"Gizinski","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal K","family":"Banda","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey P","family":"Causey","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina , Columbia, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Knuckley","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina , Columbia, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N","family":"Cordova","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina , Columbia, SC 29425"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandt","family":"Levitt","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Glogowska","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyanka","family":"Chandra","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Kulik","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P","family":"Arend","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Scripps Florida, Jupiter, FL 33458"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V Michael","family":"Holers","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"2025032411172723300_r1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/ar93","article-title":"Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset","volume":"2","author":"Goldbach-Mansky","year":"2000","journal-title":"Arthritis Res."},{"key":"2025032411172723300_r2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/clinchem\/47.6.1089","article-title":"Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis","volume":"47","author":"Bizzaro","year":"2001","journal-title":"Clin. Chem."},{"key":"2025032411172723300_r3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/ard.2006.051391","article-title":"Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review","volume":"65","author":"Avouac","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"2025032411172723300_r4","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/art.11224","article-title":"Can we accurately predict the development of rheumatoid arthritis in the preclinical phase?","volume":"48","author":"Majka","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r6","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantap\u00e4\u00e4-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2025032411172723300_r8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/ar95","article-title":"Citrullination: a small change for a protein with great consequences for rheumatoid arthritis","volume":"2","author":"van Venrooij","year":"2000","journal-title":"Arthritis Res."},{"key":"2025032411172723300_r9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gene.2003.12.038","article-title":"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6","volume":"330","author":"Chavanas","year":"2004","journal-title":"Gene"},{"key":"2025032411172723300_r10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng1206","article-title":"Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis","volume":"34","author":"Suzuki","year":"2003","journal-title":"Nat. Genet."},{"key":"2025032411172723300_r11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/art.21536","article-title":"A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans","volume":"54","author":"Kang","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10038-007-0232-4","article-title":"Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies","volume":"53","author":"Takata","year":"2008","journal-title":"J. Hum. Genet."},{"key":"2025032411172723300_r13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10495-006-3715-4","article-title":"Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells","volume":"11","author":"Liu","year":"2006","journal-title":"Apoptosis"},{"key":"2025032411172723300_r14","doi-asserted-by":"crossref","first-page":"27786","DOI":"10.1074\/jbc.274.39.27786","article-title":"Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)","volume":"274","author":"Nakashima","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2025032411172723300_r15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mce.2007.05.005","article-title":"Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility","volume":"273","author":"Esposito","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"2025032411172723300_r16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1101400","article-title":"Human PAD4 regulates histone arginine methylation levels via demethylimination","volume":"306","author":"Wang","year":"2004","journal-title":"Science"},{"key":"2025032411172723300_r17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2004.08.020","article-title":"Histone deimination antagonizes arginine methylation","volume":"118","author":"Cuthbert","year":"2004","journal-title":"Cell"},{"key":"2025032411172723300_r18","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1021\/bi047505c","article-title":"Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes","volume":"44","author":"Hagiwara","year":"2005","journal-title":"Biochemistry"},{"key":"2025032411172723300_r19","doi-asserted-by":"crossref","first-page":"49562","DOI":"10.1074\/jbc.M208795200","article-title":"Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes","volume":"277","author":"Nakashima","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032411172723300_r20","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1128\/MCB.01747-07","article-title":"Regulation of p53 target gene expression by peptidylarginine deiminase 4","volume":"28","author":"Li","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"2025032411172723300_r21","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1074\/jbc.M802940200","article-title":"Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis","volume":"283","author":"Yao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025032411172723300_r22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"key":"2025032411172723300_r23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4049\/jimmunol.182.1.666","article-title":"Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4","volume":"182","author":"Struyf","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411172723300_r24","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1084\/jem.20080305","article-title":"Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation","volume":"205","author":"Proost","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r25","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1182\/blood-2008-04-149039","article-title":"Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation","volume":"112","author":"Loos","year":"2008","journal-title":"Blood"},{"key":"2025032411172723300_r26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.177.3.1421","article-title":"Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization","volume":"177","author":"Ireland","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411172723300_r27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0012-1606(02)00126-4","article-title":"ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets","volume":"256","author":"Wright","year":"2003","journal-title":"Dev. Biol."},{"key":"2025032411172723300_r28","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/art.23618","article-title":"Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis","volume":"58","author":"Kinloch","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r29","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/art.21220","article-title":"Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity","volume":"52","author":"De Rycke","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r30","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/bi700095s","article-title":"Protein arginine deiminase 4: evidence for a reverse protonation mechanism","volume":"46","author":"Knuckley","year":"2007","journal-title":"Biochemistry"},{"key":"2025032411172723300_r31","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1021\/bi061180d","article-title":"Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization","volume":"45","author":"Luo","year":"2006","journal-title":"Biochemistry"},{"key":"2025032411172723300_r32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI25422","article-title":"Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis","volume":"116","author":"Kuhn","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032411172723300_r33","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1186\/ar2523","article-title":"Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination","volume":"10","author":"Kidd","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"2025032411172723300_r34","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1002\/art.10591","article-title":"Mechanisms of effects of complement inhibition in murine collagen-induced arthritis","volume":"46","author":"Banda","year":"2002","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r35","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M","article-title":"Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis","volume":"43","author":"Bendele","year":"2000","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r36","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.4049\/jimmunol.177.3.1904","article-title":"Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis","volume":"177","author":"Banda","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411172723300_r37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1471-4159.2002.00834.x","article-title":"Peptidylarginine deiminase: a candidate factor in demyelinating disease","volume":"81","author":"Moscarello","year":"2002","journal-title":"J. Neurochem."},{"key":"2025032411172723300_r38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(99)00276-1","article-title":"The developmental expression and activity of peptidylarginine deiminase in the mouse","volume":"266","author":"Pritzker","year":"1999","journal-title":"Neurosci. Lett."},{"key":"2025032411172723300_r39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/abio.2000.4805","article-title":"A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline","volume":"286","author":"Knipp","year":"2000","journal-title":"Anal. Biochem."},{"key":"2025032411172723300_r40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nm0302-295","article-title":"Autoantigen microarrays for multiplex characterization of autoantibody responses","volume":"8","author":"Robinson","year":"2002","journal-title":"Nat. Med."},{"key":"2025032411172723300_r41","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.21269","article-title":"Antigen microarray profiling of autoantibodies in rheumatoid arthritis","volume":"52","author":"Hueber","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r42","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411172723300_r43","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411172723300_r44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.154.3.688","article-title":"Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates","volume":"154","author":"Wooley","year":"1981","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r45","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1084\/jem.162.6.1878","article-title":"Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci","volume":"162","author":"Watson","year":"1985","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r46","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1084\/jem.20072051","article-title":"Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice","volume":"205","author":"Hill","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1136\/ard.2008.089300","article-title":"Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis","volume":"68","author":"Nickdel","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"2025032411172723300_r48","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.4049\/jimmunol.0903639","article-title":"Contribution of myelin autoantigen citrullination to T cell autoaggression in the central nervous system","volume":"184","author":"Carrillo-Vico","year":"2010","journal-title":"J. Immunol."},{"key":"2025032411172723300_r49","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.4049\/jimmunol.0900007","article-title":"A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells","volume":"183","author":"Benito-Miguel","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411172723300_r50","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/rheumatology\/kep028","article-title":"Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis","volume":"48","author":"Nistala","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"2025032411172723300_r51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r52","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1084\/jem.20080730","article-title":"CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells","volume":"205","author":"Meiron","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025032411172723300_r53","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.4049\/jimmunol.0804328","article-title":"The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity","volume":"182","author":"Scott","year":"2009","journal-title":"J. Immunol."},{"key":"2025032411172723300_r54","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/art.11229","article-title":"Citrullination of synovial proteins in murine models of rheumatoid arthritis","volume":"48","author":"Vossenaar","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2025032411172723300_r55","doi-asserted-by":"crossref","first-page":"A5","DOI":"10.1136\/ard.2010.129577l","article-title":"Detection of genuine anti-citrullinated protein antibodies in mice reveals their presence in BALB\/c but not DBA\/1 and SJL mice hyperimmunised with citrullinated collagen","volume":"69","author":"Cantaert","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"2025032411172723300_r56","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1002\/art.22983","article-title":"Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation","volume":"56","author":"Foulquier","year":"2007","journal-title":"Arthritis Rheum."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/7\/4396\/62474263\/1001620.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/7\/4396\/62474263\/1001620.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T09:42:36Z","timestamp":1743154956000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/186\/7\/4396\/7990187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,1]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1001620","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,4]]},"published":{"date-parts":[[2011,4,1]]}}}