{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:26:59Z","timestamp":1791289619867,"version":"4.3.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Interleukin-17A\u2013producing T cells, especially Th17, have been shown to be involved in inflammatory autoimmune diseases and host defense against extracellular infections. However, whether and how IL-17A or IL-17A\u2013producing cells can help protection against intracellular bacteria remains controversial, especially how it regulates the adaptive immunity besides recruitment of neutrophils in the innate immune system. By infecting IL-17A\u2013deficient mice with Listeria monocytogenes, we show in this study that IL-17A is required for the generation of Ag-specific CD8+ CTL response against primary infection, but not for the generation of memory CD8+ T cells against secondary challenge. Interestingly, we identify \u03b3\u03b4T cells, but not conventional CD4+ Th17 cells, as the main cells for innate IL-17A production during L. monocytogenes infection. Furthermore, \u03b3\u03b4T cells are found to promote Ag-specific CD8+ T cell proliferation by enhancing cross-presentation of dendritic cells through IL-17A. Adoptive transfer of Il17a+\/+ \u03b3\u03b4T cells, but not Il17a\u2212\/\u2212 \u03b3\u03b4T cells or Il17a+\/+ CD4+ T cells, were sufficient to recover dendritic cells cross-presentation and defective CD8+ T cell response in Il17a\u2212\/\u2212 mice. Our findings indicate an important role of infection-inducible IL-17A\u2013producing \u03b3\u03b4T cells and their derived IL-17A against intracellular bacterial infection, providing a mechanism of IL-17A for regulation of innate and adaptive immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1001763","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T04:19:16Z","timestamp":1287461956000},"page":"5879-5887","source":"Crossref","is-referenced-by-count":79,"title":["IL-17A\u2013Producing \u03b3\u03b4T Cells Promote CTL Responses against <i>Listeria monocytogenes<\/i> Infection by Enhancing Dendritic Cell Cross-Presentation"],"prefix":"10.1093","volume":"185","author":[{"given":"Sheng","family":"Xu","sequence":"first","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Han","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongfei","family":"Xu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University , Shanghai 200433 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"2025032412101449100_r1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat. 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