{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:55:36Z","timestamp":1790513736403,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transcriptional control of marginal zone (MZ) and follicular (FO) B cell development remains incompletely understood. The transcription factor, IFN regulatory factor (IRF)8, is known to play important roles in the differentiation of early B cells. In this article, we demonstrate that IRF8 is also required for normal development of MZ and FO B cells. Mice with a conventional knockout of Irf8 (IRF8\u2212\/\u2212) or a point mutation in the IRF association domain of IRF8 had increased numbers of MZ B cells. To determine the B cell-intrinsic effects of IRF8 deficiency, we generated mice with a conditional allele of Irf8 crossed with CD19-Cre mice (designated IRF8-conditional knockout [CKO]). These mice had enlarged MZ and increased numbers of MZ and FO B cells compared with controls. The FO B cells of CKO mice exhibited reduced expression of CD23 and moderately increased expression of CD21. Gene-expression profiling showed that increased B cell production in IRF8-CKO mice was associated with changes in expression of genes involved in regulation of transcription, signaling, and inflammation. Functional studies showed that IRF8-CKO mice generated normal Ab responses to T-independent and T-dependent Ags. Thus, IRF8 controls the expansion and maturation of MZ and FO B cells but has little effect on B cell function.<\/jats:p>","DOI":"10.4049\/jimmunol.1001950","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T03:47:49Z","timestamp":1293076069000},"page":"1458-1466","source":"Crossref","is-referenced-by-count":80,"title":["IFN Regulatory Factor 8 Restricts the Size of the Marginal Zone and Follicular B Cell Pools"],"prefix":"10.1093","volume":"186","author":[{"given":"Jianxun","family":"Feng","sequence":"first","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Mi","family":"Shin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Masiuk","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"},{"name":"Department of Pathology, Pomeranian Medical University , 70-252 Szczecin ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Feng","family":"Qi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Herbert C","family":"Morse","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"2025032411035951300_r1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1056600","article-title":"Contribution of receptor editing to the antibody repertoire","volume":"291","author":"Casellas","year":"2001","journal-title":"Science"},{"key":"2025032411035951300_r2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ni1076","article-title":"Receptor editing is the main mechanism of B cell tolerance toward membrane antigens","volume":"5","author":"Halverson","year":"2004","journal-title":"Nat. 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