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Previous studies showed that dendritic cells from B6 mice produced more Th1-type cytokines such as IL-12 than did those from BALB\/c mice in response to L. monocytogenes infection. In this report, we demonstrate that the microenvironment in L. monocytogenes-infected BALB\/c mice is sufficient to induce responsive B6 CD8+ T cells to rapidly secrete IFN-\u03b3. Furthermore, BALB\/c CD8+ T cells did not rapidly secrete IFN-\u03b3 even when they were exposed to high concentrations of IL-12 plus IL-18 in vitro. In the presence of IL-12 and IL-18, B6 CD44hiCD8+ T cells upregulated expression of the receptor subunits for these cytokines more rapidly than did BALB\/c T cells. In comparing particular subsets of memory phenotype CD8+ T cells, we found that virtual memory cells, rather than true Ag-experienced cells, had the greatest level of impairment in BALB\/c mice. These data suggest that the degree of cytokine-driven bystander activation of CD8+ T cells that occurs during infection depends on both APCs and T cell-intrinsic properties that can vary among mouse strains.<\/jats:p>","DOI":"10.4049\/jimmunol.1001960","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T01:53:49Z","timestamp":1293674029000},"page":"1703-1712","source":"Crossref","is-referenced-by-count":26,"title":["T Cell-Intrinsic Factors Contribute to the Differential Ability of CD8+ T Cells To Rapidly Secrete IFN-\u03b3 in the Absence of Antigen"],"prefix":"10.1093","volume":"186","author":[{"given":"Elsa N","family":"Bou Ghanem","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina C","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E F","family":"D\u2019Orazio","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"2025032411034092400_r1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2172-10-14","article-title":"Interferon-\u03b3 coordinates CCL3-mediated neutrophil recruitment in vivo","volume":"10","author":"Bonville","year":"2009","journal-title":"BMC Immunol."},{"key":"2025032411034092400_r2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-065X.1997.tb00994.x","article-title":"Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis","volume":"158","author":"Mielke","year":"1997","journal-title":"Immunol. 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