{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:20:00Z","timestamp":1790158800130,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nucleotide-binding domain and leucine rich repeat containing gene family receptors (NLRs) are cytosolic proteins that respond to a variety of pathogen and host components to induce inflammatory cytokines. NLRC5 is a recently identified member of the NLR family that has been implicated in positive and negative regulation of antiviral innate immune responses. To clarify whether NLRC5 controls antiviral innate immunity in vivo, we generated NLRC5-deficient mice. Macrophages and dendritic cells derived from NLRC5-deficient mice induced relatively normal levels of IFN-\u03b2, IL-6, and TNF-\u03b1 after treatment with RNA viruses, DNA viruses, and bacteria. The serum cytokine levels after polyinosinic-polycytidylic acid infection were also comparable between control and NLRC5-deficient mice. NLRC5 overexpression promoted IL-1\u03b2 production via caspase-1, suggesting that NLRC5 constitutes an inflammasome. However, there was no reduction of IL-1\u03b2 in NLRC5-deficient cells in response to known inflammasome activators, suggesting that NLRC5 controls IL-1\u03b2 production through an unidentified pathway. These findings indicate that NLRC5 is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions.<\/jats:p>","DOI":"10.4049\/jimmunol.1002094","type":"journal-article","created":{"date-parts":[[2010,12,9]],"date-time":"2010-12-09T04:03:14Z","timestamp":1291867394000},"page":"994-1000","source":"Crossref","is-referenced-by-count":94,"title":["NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections"],"prefix":"10.1093","volume":"186","author":[{"given":"Himanshu","family":"Kumar","sequence":"first","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]},{"name":"Laboratory of Immunology, Department of Biological Sciences, Indian Institute of Science Education and Research , Bhopal ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Pandey","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zou","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka ,","place":["Japan"]},{"name":"Department of Host Defense, Research Institute for Microbial Diseases, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,15]]},"reference":[{"key":"2025032411004630200_r1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"2025032411004630200_r2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. 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