{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:33:18Z","timestamp":1767846798077,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Day 3 thymectomy (D3Tx) results in a loss of peripheral tolerance mediated by natural regulatory T cells (nTregs) and development of autoimmune ovarian dysgenesis (AOD) and autoimmune dacryoadenitis (ADA) in A\/J and (C57BL\/6J \u00d7 A\/J) F1 hybrids (B6A), but not in C57BL\/6J (B6) mice. Previously, using quantitative trait locus (QTL) linkage analysis, we showed that D3Tx-AOD is controlled by five unlinked QTL (Aod1-Aod5) and H2. In this study, using D3Tx B6-ChrA\/J\/NaJ chromosome (Chr) substitution strains, we confirm that QTL on Chr16 (Aod1a\/Aod1b), Chr3 (Aod2), Chr1 (Aod3), Chr2 (Aod4), Chr7 (Aod5), and Chr17 (H2) control D3Tx-AOD susceptibility. In addition, we also present data mapping QTL controlling D3Tx-ADA to Chr17 (Ada1\/H2), Chr1 (Ada2), and Chr3 (Ada3). Importantly, B6-ChrXA\/J mice were as resistant to D3Tx-AOD and D3Tx-ADA as B6 mice, thereby excluding Foxp3 as a susceptibility gene in these models. Moreover, we report quantitative differences in the frequency of nTregs in the lymph nodes (LNs), but not spleen or thymus, of AOD\/ADA-resistant B6 and AOD\/ADA-susceptible A\/J, B6A, and B6-Chr17A\/J mice. Similar results correlating with experimental allergic encephalomyelitis and orchitis susceptibility were seen with B10.S and SJL\/J mice. Using H2-congenic mice, we show that the observed difference in frequency of LN nTregs is controlled by Ada1\/H2. These data support the existence of an LN-specific, H2-controlled mechanism regulating the prevalence of nTregs in autoimmune disease susceptibility.<\/jats:p>","DOI":"10.4049\/jimmunol.1002110","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T06:27:28Z","timestamp":1291703248000},"page":"382-389","source":"Crossref","is-referenced-by-count":14,"title":["<i>H2<\/i> Control of Natural T Regulatory Cell Frequency in the Lymph Node Correlates with Susceptibility to Day 3 Thymectomy-Induced Autoimmune Disease"],"prefix":"10.1093","volume":"186","author":[{"given":"Roxana","family":"del Rio","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Alard","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"},{"name":"Health Sciences Center, University of Louisville , Louisville, KY 40202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S K","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory","family":"Teuscher","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2025032410542536000_r1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.immuni.2009.04.009","article-title":"Control of regulatory T cell lineage commitment and maintenance","volume":"30","author":"Josefowicz","year":"2009","journal-title":"Immunity"},{"key":"2025032410542536000_r2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"2025032410542536000_r3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.immunol.24.021605.090547","article-title":"FOXP3: of mice and men","volume":"24","author":"Ziegler","year":"2006","journal-title":"Annu. 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