{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:47:31Z","timestamp":1764251251213,"version":"3.40.3"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-13 is expressed in lesions of atopic dermatitis (AD) and has been associated with increased disease severity. IL-13 has two cognate receptors: IL-13R\u03b11 and IL-13R\u03b12. Although IL-13R\u03b12 expression is known to be induced in response to IL-13 in keratinocytes, its function in AD has never been evaluated. We characterized the loss of skin barrier function and the development of cutaneous inflammation in IL-13R\u03b12\u2013null versus wild-type BALB\/c mice following an epicutaneous allergen-sensitization\/challenge model that shares similarities with human AD. Mice lacking IL-13R\u03b12 had significantly increased transepidermal water loss, cutaneous inflammation, peripheral eosinophilia, and IgG1 and IgE levels compared with wild-type mice. The rate of resolution of the cutaneous inflammation was not significantly altered in the IL-13R\u03b12\u2013null mice. IL-13 induced expression of IL-13R\u03b12 in keratinocyte cell lines and primary human keratinocytes. Depletion of IL-13R\u03b12 in a keratinocyte cell line resulted in increased STAT6 signaling in response to IL-13. In conclusion, IL-13R\u03b12 serves a protective role in the pathogenesis of allergic inflammation and loss of skin barrier function in a mouse model of AD, suggesting that it may be an important endogenous regulator of IL-13\u2013induced cutaneous inflammation in humans.<\/jats:p>","DOI":"10.4049\/jimmunol.1002118","type":"journal-article","created":{"date-parts":[[2010,10,23]],"date-time":"2010-10-23T01:12:20Z","timestamp":1287796340000},"page":"6802-6808","source":"Crossref","is-referenced-by-count":35,"title":["IL-13R\u03b12 Has a Protective Role in a Mouse Model of Cutaneous Inflammation"],"prefix":"10.1093","volume":"185","author":[{"given":"Umasundari","family":"Sivaprasad","sequence":"first","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj R","family":"Warrier","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Division of Allergy and Immunology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M","family":"Gibson","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Tabata","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey A","family":"Bass","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc E","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjit K","family":"Khurana Hershey","sequence":"additional","affiliation":[{"name":"Division of Asthma Research, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Division of Allergy and Immunology, Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH 45229"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"2025032412144959600_r1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"113","author":"Leung","year":"2004","journal-title":"J. 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