{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:41:27Z","timestamp":1790797287934,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Influenza A virus (IAV) infection results in a highly contagious respiratory illness leading to substantial morbidity and occasionally death. In this report, we assessed the in vivo physiological contribution of invariant NKT (iNKT) lymphocytes, a subset of lipid-reactive \u03b1\u03b2 T lymphocytes, on the host response and viral pathogenesis using a virulent, mouse-adapted, IAV H3N2 strain. Upon infection with a lethal dose of IAV, iNKT cells become activated in the lungs and bronchoalveolar space to become rapidly anergic to further restimulation. Relative to wild-type animals, C57BL\/6 mice deficient in iNKT cells (J\u03b118\u2212\/\u2212 mice) developed a more severe bronchopneumonia and had an accelerated fatal outcome, a phenomenon reversed by the adoptive transfer of NKT cells prior to infection. The enhanced pathology in J\u03b118\u2212\/\u2212 animals was not associated with either reduced or delayed viral clearance in the lungs or with a defective local NK cell response. In marked contrast, J\u03b118\u2212\/\u2212 mice displayed a dramatically reduced IAV-specific CD8+ T cell response in the lungs and in lung-draining mediastinal lymph nodes. We further show that this defective CD8+ T cell response correlates with an altered accumulation and maturation of pulmonary CD103+, but not CD11bhigh, dendritic cells in the mediastinal lymph nodes. Taken together, these findings point to a role for iNKT cells in the control of pneumonia as well as in the development of the CD8+ T cell response during the early stage of acute IAV H3N2 infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1002348","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T22:19:53Z","timestamp":1302733193000},"page":"5590-5602","source":"Crossref","is-referenced-by-count":108,"title":["Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia"],"prefix":"10.1093","volume":"186","author":[{"given":"Christophe","family":"Paget","sequence":"first","affiliation":[{"name":"Institut Pasteur de Lille, Centre d\u2019Infection et d\u2019Immunit\u00e9 de Lille , F-59019 Lille ,","place":["France"]},{"name":"Universit\u00e9 Lille Nord de France , F-59000 Lille ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8204 , F-59021 Lille ,","place":["France"]},{"name":"INSERM, U1019 , F-59019 Lille ,","place":["France"]},{"name":"Institut F\u00e9d\u00e9ratif de Recherche 142 , F-59019 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stoyan","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Lille, Centre d\u2019Infection et d\u2019Immunit\u00e9 de Lille , F-59019 Lille ,","place":["France"]},{"name":"Universit\u00e9 Lille Nord de France , F-59000 Lille ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8204 , F-59021 Lille ,","place":["France"]},{"name":"INSERM, U1019 , F-59019 Lille ,","place":["France"]},{"name":"Institut F\u00e9d\u00e9ratif de Recherche 142 , F-59019 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Institut 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