{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:29:50Z","timestamp":1790429390288,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoreactive T cells, responsible for the destruction of pancreatic \u03b2 cells in type 1 diabetes, are known to have a skewed TCR repertoire in the NOD mouse. To define the autoreactive T cell repertoire in human diabetes, we searched for intraislet monoclonal expansions from a recent onset in human pancreas to then trace them down to the patient\u2019s peripheral blood and spleen. Islet infiltration was diverse, but five monoclonal TCR \u03b2-chain variable expansions were detected for V\u03b21, V\u03b27, V\u03b211, V\u03b217, and V\u03b222 families. To identify any sequence bias in the TCRs from intrapancreatic T cells, we analyzed 139 different CDR3 sequences. We observed amino acid preferences in the NDN region that suggested a skewed TCR repertoire within infiltrating T cells. The monoclonal expanded TCR sequences contained amino acid combinations that fit the observed bias. Using these CDR3 sequences as a marker, we traced some of these expansions in the spleen. There, we identified a V\u03b222 monoclonal expansion with identical CDR3 sequence to that found in the islets within a polyclonal TCR \u03b2-chain variable repertoire. The same V\u03b222 TCR was detected in the patient\u2019s PBMCs, making a cross talk between the pancreas and spleen that was reflected in peripheral blood evident. No other pancreatic monoclonal expansions were found in peripheral blood or the spleen, suggesting that the V\u03b222 clone may have expanded or accumulated in situ by an autoantigen present in both the spleen and pancreas. Thus, the patient\u2019s spleen might be contributing to disease perpetuation by expanding or retaining some autoreactive T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1002423","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T03:58:08Z","timestamp":1297915088000},"page":"3787-3797","source":"Crossref","is-referenced-by-count":40,"title":["TCR Bias of In Vivo Expanded T Cells in Pancreatic Islets and Spleen at the Onset in Human Type 1 Diabetes"],"prefix":"10.1093","volume":"186","author":[{"given":"Eva","family":"Codina-Busqueta","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Scholz","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau M","family":"Mu\u00f1oz-Torres","sequence":"additional","affiliation":[{"name":"Group of Computational Biology and Proteomics, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Roura-Mir","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Xufr\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Planas","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Application to Diagnosis, Blood, and Tissue Bank, Research Institute Germans Trias i Pujol , E-08916 Badalona, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vives-Pi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology for Research and Application to Diagnosis, Blood, and Tissue Bank, Research Institute Germans Trias i Pujol , E-08916 Badalona, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Jaraquemada","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Immunology, Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona , E-08193 Bellaterra, Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"2025032411143156000_r1","first-page":"117","article-title":"The role of T cells in beta cell damage in NOD mice and humans","volume":"552","author":"Kelemen","year":"2004","journal-title":"Adv. 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Immunol."},{"key":"2025032411143156000_r5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11892-004-0062-0","article-title":"T-cell epitopes in type 1 diabetes","volume":"4","author":"Panagiotopoulos","year":"2004","journal-title":"Curr. Diab. Rep."},{"key":"2025032411143156000_r6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2006.03244.x","article-title":"Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes","volume":"148","author":"Di Lorenzo","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"2025032411143156000_r7","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.2337\/diab.43.11.1318","article-title":"HLA-DQ-restricted, islet-specific T-cell clones of a type I diabetic patient. 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