{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:11:43Z","timestamp":1768720303788,"version":"3.49.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Guanylate cyclase C (GUCY2C or GC-C) and its ligands, guanylin (GUCA2A or Gn) and uroguanylin (GUCA2B or Ugn), are expressed in intestinal epithelial cells and regulate ion secretion, intestinal barrier function, and epithelial monolayer homeostasis via cGMP-dependent signaling pathways. The aim of this study was to determine whether GC-C and its ligands direct the course of intestinal inflammation. In this article, we show that dextran sodium sulfate (DSS)-induced clinical disease and histological damage to the colonic mucosa were significantly less severe in GC-C\u2212\/\u2212 mice and moderately reduced in Gn\u2212\/\u2212 animals. Relative to wild-type controls, GC-C\u2212\/\u2212 and Gn\u2212\/\u2212 mice had reduced apoptosis and increased proliferation of intestinal epithelial cells during DSS colitis. Basal and DSS-induced production of resistin-like molecule \u03b2 (RELM\u03b2) was substantially diminished in GC-C\u2212\/\u2212 mice. RELM\u03b2 is thought to stimulate cytokine production in macrophages in this disease model and, consistent with this, TNF-\u03b1 and IFN-\u03b3 production was minimal in GC-C\u2212\/\u2212 animals. RELM\u03b2 and cytokine levels were similar to wild-type in Gn\u2212\/\u2212 mice, however. Colonic instillation of recombinant RELM\u03b2 by enema into GC-C\u2212\/\u2212 mice restores sensitivity to DSS-mediated mucosal injury. These findings demonstrate a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELM\u03b2 production.<\/jats:p>","DOI":"10.4049\/jimmunol.1002469","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T06:09:45Z","timestamp":1305007785000},"page":"7205-7214","source":"Crossref","is-referenced-by-count":57,"title":["Murine Guanylate Cyclase C Regulates Colonic Injury and Inflammation"],"prefix":"10.1093","volume":"186","author":[{"given":"Kris A","family":"Steinbrecher","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleana","family":"Harmel-Laws","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica P","family":"Garin-Laflam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Mann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas D","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Allergy and Immunology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell B","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"2025032411313227300_r1","first-page":"579","volume-title":"Infections of the Gastrointestinal Tract.","author":"Cohen","year":"2002"},{"key":"2025032411313227300_r2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1073\/pnas.89.3.947","article-title":"Guanylin: an endogenous activator of intestinal guanylate cyclase","volume":"89","author":"Currie","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411313227300_r3","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1073\/pnas.90.22.10464","article-title":"Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase","volume":"90","author":"Hamra","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411313227300_r4","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1172\/JCI119683","article-title":"Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice","volume":"100","author":"Schulz","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2025032411313227300_r5","doi-asserted-by":"crossref","first-page":"16642","DOI":"10.1074\/jbc.M500505200","article-title":"cGMP inhibition of Na+\/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein","volume":"280","author":"Cha","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025032411313227300_r6","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/j.1460-2075.1994.tb06355.x","article-title":"Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase","volume":"13","author":"Chao","year":"1994","journal-title":"EMBO J."},{"key":"2025032411313227300_r7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0016-5085(00)70419-7","article-title":"Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon","volume":"118","author":"Vaandrager","year":"2000","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0016-5085(88)90423-4","article-title":"Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children","volume":"94","author":"Cohen","year":"1988","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r9","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1172\/JCI200318743","article-title":"Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load","volume":"112","author":"Lorenz","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2025032411313227300_r10","doi-asserted-by":"crossref","first-page":"7846","DOI":"10.1073\/pnas.141124698","article-title":"Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells","volume":"98","author":"Pitari","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411313227300_r11","doi-asserted-by":"crossref","first-page":"e16139","DOI":"10.1371\/journal.pone.0016139","article-title":"Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier","volume":"6","author":"Han","year":"2011","journal-title":"PLoS ONE"},{"key":"2025032411313227300_r12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.peptides.2006.12.009","article-title":"Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A","volume":"28","author":"Vellaichamy","year":"2007","journal-title":"Peptides"},{"key":"2025032411313227300_r13","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.3748\/wjg.v11.i47.7418","article-title":"Hepatocyte cytoskeleton during ischemia and reperfusion\u2014influence of ANP-mediated p38 MAPK activation","volume":"11","author":"Keller","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"2025032411313227300_r14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.165.1.175","article-title":"cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages","volume":"165","author":"Kiemer","year":"2000","journal-title":"J. Immunol."},{"key":"2025032411313227300_r15","doi-asserted-by":"crossref","first-page":"iii68","DOI":"10.1136\/ard.60.90003.iii68","article-title":"The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages","volume":"60","author":"Kiemer","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"2025032411313227300_r16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0168-8278(00)80364-5","article-title":"Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1","volume":"33","author":"Kiemer","year":"2000","journal-title":"J. Hepatol."},{"key":"2025032411313227300_r17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1172\/JCI12088","article-title":"Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia\/reperfusion injury","volume":"108","author":"Izumi","year":"2001","journal-title":"J. Clin. Invest."},{"key":"2025032411313227300_r18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/ibd.20110","article-title":"Genome-wide gene expression differences in Crohn\u2019s disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis","volume":"13","author":"Wu","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032411313227300_r19","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/gb-2008-9-8-r122","article-title":"Diarrhea as a cause of mortality in a mouse model of infectious colitis","volume":"9","author":"Borenshtein","year":"2008","journal-title":"Genome Biol."},{"key":"2025032411313227300_r20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1053\/j.gastro.2009.05.043","article-title":"Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury","volume":"137","author":"Kiela","year":"2009","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r21","doi-asserted-by":"crossref","first-page":"G63","DOI":"10.1152\/ajpgi.90207.2008","article-title":"Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis","volume":"295","author":"Laubitz","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032411313227300_r22","doi-asserted-by":"crossref","first-page":"49036","DOI":"10.1074\/jbc.M205288200","article-title":"In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+\/H+ exchanger knockout model of congenital diarrhea","volume":"277","author":"Woo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032411313227300_r23","doi-asserted-by":"crossref","first-page":"G104","DOI":"10.1152\/ajpgi.00548.2006","article-title":"Altered transit and bacterial overgrowth in the cystic fibrosis mouse small intestine","volume":"293","author":"De Lisle","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032411313227300_r24","doi-asserted-by":"crossref","first-page":"G1032","DOI":"10.1152\/ajpgi.00473.2003","article-title":"Inflammation of the cystic fibrosis mouse small intestine","volume":"286","author":"Norkina","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032411313227300_r25","doi-asserted-by":"crossref","first-page":"e4664","DOI":"10.1371\/journal.pone.0004664","article-title":"CFTR is a negative regulator of NFkappaB mediated innate immune response","volume":"4","author":"Vij","year":"2009","journal-title":"PLoS ONE"},{"key":"2025032411313227300_r26","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.bcp.2007.03.019","article-title":"Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways","volume":"73","author":"Verhaeghe","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"2025032411313227300_r27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/bbrc.1997.7487","article-title":"Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion","volume":"239","author":"Mann","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025032411313227300_r28","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/S0002-9440(10)64494-X","article-title":"Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation","volume":"161","author":"Steinbrecher","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2025032411313227300_r29","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-09-3465","article-title":"Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen","volume":"70","author":"Steinbrecher","year":"2010","journal-title":"Cancer Res."},{"key":"2025032411313227300_r30","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.4049\/jimmunol.180.4.2588","article-title":"Loss of epithelial RelA results in deregulated intestinal proliferative\/apoptotic homeostasis and susceptibility to inflammation","volume":"180","author":"Steinbrecher","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411313227300_r31","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.4049\/jimmunol.0903164","article-title":"Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice","volume":"184","author":"Barnes","year":"2010","journal-title":"J. Immunol."},{"key":"2025032411313227300_r32","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/0016-5085(95)90753-X","article-title":"Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine","volume":"109","author":"Li","year":"1995","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r33","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI28121","article-title":"Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis","volume":"116","author":"McVay","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2025032411313227300_r34","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/ibd.20420","article-title":"Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice","volume":"14","author":"Krimi","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032411313227300_r35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1053\/gast.2001.28680","article-title":"Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent","volume":"121","author":"Steinbrecher","year":"2001","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r36","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1210\/endo.141.9.7644","article-title":"Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine","volume":"141","author":"Qian","year":"2000","journal-title":"Endocrinology"},{"key":"2025032411313227300_r37","doi-asserted-by":"crossref","first-page":"G740","DOI":"10.1152\/ajpgi.90268.2008","article-title":"Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis","volume":"296","author":"Garin-Laflam","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032411313227300_r38","doi-asserted-by":"crossref","first-page":"G327","DOI":"10.1152\/ajpgi.00422.2010","article-title":"Importance and regulation of the colonic mucus barrier in a mouse model of colitis","volume":"300","author":"Petersson","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025032411313227300_r39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1126\/science.274.5285.262","article-title":"Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor","volume":"274","author":"Mashimo","year":"1996","journal-title":"Science"},{"key":"2025032411313227300_r41","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1172\/JCI6211","article-title":"A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells","volume":"104","author":"Itoh","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2025032411313227300_r42","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1073\/pnas.0404034101","article-title":"RELMbeta\/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract","volume":"101","author":"Artis","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411313227300_r43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2006.04.039","article-title":"Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility","volume":"118","author":"Hogan","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025032411313227300_r44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/mi.2008.77","article-title":"Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans","volume":"2","author":"M\u00f6ndel","year":"2009","journal-title":"Mucosal Immunol."},{"key":"2025032411313227300_r45","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.immuni.2010.03.001","article-title":"Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways","volume":"32","author":"Nava","year":"2010","journal-title":"Immunity"},{"key":"2025032411313227300_r46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0002-9440(10)62264-X","article-title":"Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression","volume":"166","author":"Wang","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2025032411313227300_r47","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1053\/j.gastro.2006.08.022","article-title":"IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction","volume":"131","author":"Wang","year":"2006","journal-title":"Gastroenterology"},{"key":"2025032411313227300_r48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-540-68964-5_4","article-title":"Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases","volume":"191","author":"Kuhn","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"2025032411313227300_r49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/geno.1997.4942","article-title":"The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4","volume":"45","author":"Whitaker","year":"1997","journal-title":"Genomics"},{"key":"2025032411313227300_r50","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.4049\/jimmunol.179.10.7012","article-title":"Resistin-like molecule beta (RELMbeta\/FIZZ2) is highly expressed in the ileum of SAMP1\/YitFc mice and is associated with initiation of ileitis","volume":"179","author":"Barnes","year":"2007","journal-title":"J. Immunol."},{"key":"2025032411313227300_r51","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.4049\/jimmunol.181.7.4709","article-title":"Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation","volume":"181","author":"Nair","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411313227300_r52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ccr.2009.01.001","article-title":"IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer","volume":"15","author":"Grivennikov","year":"2009","journal-title":"Cancer Cell"},{"key":"2025032411313227300_r53","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411313227300_r54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1753425908088724","article-title":"Mice deficient in the CXCR2 ligand, CXCL1 (KC\/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis","volume":"14","author":"Shea-Donohue","year":"2008","journal-title":"Innate Immun."},{"key":"2025032411313227300_r55","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1189\/jlb.1205734","article-title":"Suppression of experimental colitis by intestinal mononuclear phagocytes","volume":"80","author":"Qualls","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2025032411313227300_r56","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ibd.20733","article-title":"Suppression of experimental colitis in mice by CD11c+ dendritic cells","volume":"15","author":"Qualls","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"2025032411313227300_r57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.2008.150888","article-title":"Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse","volume":"58","author":"Arrieta","year":"2009","journal-title":"Gut"},{"key":"2025032411313227300_r58","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ajg.2008.59","article-title":"Pilot study on the effect of linaclotide in patients with chronic constipation","volume":"104","author":"Johnston","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"2025032411313227300_r59","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1053\/j.gastro.2010.08.041","article-title":"Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation","volume":"139","author":"Johnston","journal-title":"Gastroenterology"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/12\/7205\/61732832\/1002469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/12\/7205\/61732832\/1002469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T19:24:33Z","timestamp":1743189873000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/186\/12\/7205\/7996591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1002469","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,6]]},"published":{"date-parts":[[2011,6]]}}}