{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:40:03Z","timestamp":1791405603637,"version":"4.3.3"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Central tolerance toward tissue-restricted Ags is considered to rely on ectopic expression in the thymus, which was also observed for tumor Ags encoded by cancer-germline genes. It is unknown whether endogenous expression shapes the T cell repertoire against the latter Ags and explains their weak immunogenicity. We addressed this question using mouse cancer-germline gene P1A, which encodes antigenic peptide P1A35\u201343 presented by H-2Ld. We made P1A-knockout (P1A-KO) mice and asked whether their anti-P1A35\u201343 immune responses were stronger than those of wild-type mice and whether P1A-KO mice responded to other P1A epitopes, against which wild-type mice were tolerized. We observed that both types of mice mounted similar P1A35\u201343-specific CD8 T cell responses, although the frequency of P1A35\u201343-specific CD8 T cells generated in response to P1A-expressing tumors was slightly higher in P1A-KO mice. This higher reactivity allowed naive P1A-KO mice to reject spontaneously P1A-expressing tumors, which progressed in wild-type mice. TCR-V\u03b2 usage of P1A35\u201343-specific CD8 cells was slightly modified in P1A-KO mice. Peptide P1A35\u201343 remained the only P1A epitope recognized by CD8 T cells in both types of mice, which also displayed similar thymic selection of a transgenic TCR recognizing P1A35\u201343. These results indicate the existence of a minimal tolerance to an Ag encoded by a cancer-germline gene and suggest that its endogenous expression only slightly affects diversification of the T cell repertoire against this Ag.<\/jats:p>","DOI":"10.4049\/jimmunol.1002612","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T20:23:45Z","timestamp":1322943825000},"page":"111-121","source":"Crossref","is-referenced-by-count":30,"title":["Minimal Tolerance to a Tumor Antigen Encoded by a Cancer-Germline Gene"],"prefix":"10.1093","volume":"188","author":[{"given":"Ivo J","family":"Huijbers","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00efdi M","family":"Soudja","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e , 13288 Marseille ,","place":["France"]},{"name":"INSERM , U631, 13288 Marseille ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102 , 13288 Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Uyttenhove","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Buferne","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e , 13288 Marseille 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,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pilotte","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line G","family":"Powis de Tenbossche","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Chomez","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Brasseur","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research , Brussels B-1200 ,","place":["Belgium"]},{"name":"de Duve Institute, Universit\u00e9 catholique de Louvain , Brussels B-1200 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Schmitt-Verhulst","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e , 13288 Marseille ,","place":["France"]},{"name":"INSERM , U631, 13288 Marseille ,","place":["France"]},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102 , 13288 Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet J","family":"Van den Eynde","sequence":"additional","affiliation":[{"name":"Ludwig Institute for 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