{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:14:06Z","timestamp":1792678446454,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The cytokines generated locally in response to infection play an important role in CD8 T cell trafficking, survival, and effector function, rendering these signals prime candidates for immune intervention. In this paper, we show that localized increases in the homeostatic cytokine IL-15 induced by influenza infection is responsible for the migration of CD8 effector T cells to the site of infection. Moreover, intranasal delivery of IL-15\u2013IL-15R\u03b1 soluble complexes (IL-15c) specifically restores the frequency of effector T cells lost in the lung airways of IL-15\u2013deficient animals after influenza infection. Exogenous IL-15c quantitatively augments the respiratory CD8 T cell response, and continued administration of IL-15c throughout the contraction phase of the anti-influenza CD8 T cell response magnifies the resultant CD8 T cell memory generated in situ. This treatment extends the ability of these cells to protect against heterologous infection, immunity that typically depreciates over time. Overall, our studies describe what to our knowledge is a new function for IL-15 in attracting effector CD8 T cells to the lung airways and suggest that adjuvanting IL-15 could be used to prolong anti-influenza CD8 T cell responses at mucosal surfaces to facilitate pathogen elimination.<\/jats:p>","DOI":"10.4049\/jimmunol.1002613","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T05:24:36Z","timestamp":1290489876000},"page":"174-182","source":"Crossref","is-referenced-by-count":54,"title":["A Role for IL-15 in the Migration of Effector CD8 T Cells to the Lung Airways following Influenza Infection"],"prefix":"10.1093","volume":"186","author":[{"given":"Katherine C","family":"Verbist","sequence":"first","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D","family":"Klonowski","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, University of Georgia , Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2025032410570026400_r1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04239","article-title":"Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution","volume":"437","author":"Ghedin","year":"2005","journal-title":"Nature"},{"key":"2025032410570026400_r2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/viro.1998.9521","article-title":"Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues","volume":"254","author":"Nguyen","year":"1999","journal-title":"Virology"},{"key":"2025032410570026400_r3","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.4049\/jimmunol.152.4.1653","article-title":"Heterosubtypic immunity to influenza type A virus in mice. 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