{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:26Z","timestamp":1791398306947,"version":"4.3.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mouse dendritic cells (DC) have been extensively studied in various tissues, especially spleen, and they comprise subsets with distinct developmental origins, surface phenotypes, and functions. Considerably less is known about human DC due to their rarity in blood and inaccessibility of other human tissues. The study of DC in human blood has revealed four subsets distinct in phenotype and function. In this study, we describe four equivalent DC subsets in human spleen obtained from deceased organ donors. We identify three conventional DC subsets characterized by surface expression of CD1b\/c, CD141, and CD16, and one plasmacytoid DC subset characterized by CD304 expression. Human DC subsets in spleen were very similar to those in human blood with respect to surface phenotype, TLR and transcription factor expression, capacity to stimulate T cells, cytokine secretion, and cross-presentation of exogenous Ag. However, organ donor health status, in particular treatment with corticosteroid methylprednisolone and brain death, may affect DC phenotype and function. DC T cell stimulatory capacity was reduced but DC were qualitatively unchanged in methylprednisolone-treated deceased organ donor spleen compared with healthy donor blood. Overall, our findings indicate that human blood DC closely resemble human spleen DC. Furthermore, we confirm parallels between human and mouse DC subsets in phenotype and function, but also identify differences in transcription factor and TLR expression as well as functional properties. In particular, the hallmark functions of mouse CD8\u03b1+ DC subsets, that is, IL-12p70 secretion and cross-presentation, are not confined to the equivalent human CD141+ DC but are shared by CD1b\/c+ and CD16+ DC subsets.<\/jats:p>","DOI":"10.4049\/jimmunol.1002632","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T02:16:42Z","timestamp":1303525002000},"page":"6207-6217","source":"Crossref","is-referenced-by-count":230,"title":["Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status"],"prefix":"10.1093","volume":"186","author":[{"given":"Diana","family":"Mittag","sequence":"first","affiliation":[{"name":"Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna I","family":"Proietto","sequence":"additional","affiliation":[{"name":"Immunology Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loudovaris","sequence":"additional","affiliation":[{"name":"Immunology and Diabetes Unit, St. Vincent\u2019s Institute , Fitzroy, Victoria 3065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart I","family":"Mannering","sequence":"additional","affiliation":[{"name":"Immunology and Diabetes Unit, St. Vincent\u2019s Institute , Fitzroy, Victoria 3065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vremec","sequence":"additional","affiliation":[{"name":"Immunology Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shortman","sequence":"additional","affiliation":[{"name":"Immunology Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Immunology Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard C","family":"Harrison","sequence":"additional","affiliation":[{"name":"Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,1]]},"reference":[{"key":"2025032411293715500_r1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411293715500_r2","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.4049\/jimmunol.164.6.2978","article-title":"CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen","volume":"164","author":"Vremec","year":"2000","journal-title":"J. Immunol."},{"key":"2025032411293715500_r3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.184.4.1413","article-title":"Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo","volume":"184","author":"De Smedt","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r4","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1084\/jem.186.11.1819","article-title":"In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas","volume":"186","author":"Reis e Sousa","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.imbio.2004.03.002","article-title":"Differential production of inflammatory chemokines by murine dendritic cell subsets","volume":"209","author":"Proietto","year":"2004","journal-title":"Immunobiology"},{"key":"2025032411293715500_r6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.0105-2896.2009.00870.x","article-title":"The CD8+ dendritic cell subset","volume":"234","author":"Shortman","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025032411293715500_r7","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20021031","article-title":"Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8+ dendritic cells only after microbial stimulus","volume":"196","author":"O\u2019Keeffe","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r8","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U","article-title":"Identification of CpG oligonucleotide sequences with high induction of IFN-\u03b1\/\u03b2 in plasmacytoid dendritic cells","volume":"31","author":"Krug","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"2025032411293715500_r9","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.4049\/jimmunol.166.4.2291","article-title":"Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c\u2212 type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN","volume":"166","author":"Kadowaki","year":"2001","journal-title":"J. Immunol."},{"key":"2025032411293715500_r10","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1002\/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q","article-title":"Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells","volume":"31","author":"Jarrossay","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"2025032411293715500_r11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature06175","article-title":"Taking dendritic cells into medicine","volume":"449","author":"Steinman","year":"2007","journal-title":"Nature"},{"key":"2025032411293715500_r12","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","article-title":"Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor \u03b1","volume":"179","author":"Sallusto","year":"1994","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r13","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"Dzionek","year":"2000","journal-title":"J. Immunol."},{"key":"2025032411293715500_r14","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1182\/blood-2001-11-0097","article-title":"Characterization of human blood dendritic cell subsets","volume":"100","author":"MacDonald","year":"2002","journal-title":"Blood"},{"key":"2025032411293715500_r15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/1521-4141(200101)31:1<48::AID-IMMU48>3.0.CO;2-5","article-title":"Identification of a novel dendritic cell-like subset of CD64+\/CD16+ blood monocytes","volume":"31","author":"Grage-Griebenow","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"2025032411293715500_r16","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20020207","article-title":"Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets","volume":"195","author":"Ito","year":"2002","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r17","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/gb-2008-9-1-r17","article-title":"Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling","volume":"9","author":"Robbins","year":"2008","journal-title":"Genome Biol."},{"key":"2025032411293715500_r18","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1172\/JCI34584","article-title":"Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin","volume":"118","author":"Sancho","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025032411293715500_r19","doi-asserted-by":"crossref","first-page":"16693","DOI":"10.1074\/jbc.M709923200","article-title":"CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes","volume":"283","author":"Huysamen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025032411293715500_r20","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1182\/blood-2008-05-155176","article-title":"The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement","volume":"112","author":"Caminschi","year":"2008","journal-title":"Blood"},{"key":"2025032411293715500_r21","doi-asserted-by":"crossref","first-page":"21955","DOI":"10.1074\/jbc.M502095200","article-title":"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule","volume":"280","author":"Galibert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025032411293715500_r22","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r23","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.20100223","article-title":"The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8\u03b1+ dendritic cells","volume":"207","author":"Crozat","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1084\/jem.20092140","article-title":"Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens","volume":"207","author":"Jongbloed","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20092618","article-title":"Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8\u03b1+ dendritic cells","volume":"207","author":"Poulin","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1189\/jlb.0806510","article-title":"The CD14+ CD16+ blood monocytes: their role in infection and inflammation","volume":"81","author":"Ziegler-Heitbrock","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2025032411293715500_r27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-3083.2007.02051.x","article-title":"Peripheral blood CD14high CD16+ monocytes are main producers of IL-10","volume":"67","author":"Skrzeczy\u0144ska-Moncznik","year":"2008","journal-title":"Scand. J. Immunol."},{"key":"2025032411293715500_r28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.1170540","article-title":"In vivo analysis of dendritic cell development and homeostasis","volume":"324","author":"Liu","year":"2009","journal-title":"Science"},{"key":"2025032411293715500_r29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2249.2008.03734.x","article-title":"Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes","volume":"154","author":"Vel\u00e1squez-Lopera","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"2025032411293715500_r30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/0885066608324208","article-title":"Aggressive organ donor management protocol","volume":"23","author":"DuBose","year":"2008","journal-title":"J. Intensive Care Med."},{"key":"2025032411293715500_r31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.med.46.1.235","article-title":"Organ preservation","volume":"46","author":"Southard","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"2025032411293715500_r32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2172-6-17","article-title":"Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT","volume":"6","author":"Maecker","year":"2005","journal-title":"BMC Immunol."},{"key":"2025032411293715500_r33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-1759(00)00173-3","article-title":"Freezing of dendritic cells, generated from cryopreserved leukaphereses, does not influence their ability to induce antigen-specific immune responses or functionally react to maturation stimuli","volume":"240","author":"Lewalle","year":"2000","journal-title":"J. Immunol. Methods"},{"key":"2025032411293715500_r34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00002371-200401000-00003","article-title":"Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated from peripheral blood CD14+ monocytes","volume":"27","author":"Hori","year":"2004","journal-title":"J. Immunother."},{"key":"2025032411293715500_r35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/326881a0","article-title":"Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2","volume":"326","author":"Gotch","year":"1987","journal-title":"Nature"},{"key":"2025032411293715500_r36","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1097\/00007890-199806270-00001","article-title":"Effects of explosive brain death on cytokine activation of peripheral organs in the rat","volume":"65","author":"Takada","year":"1998","journal-title":"Transplantation"},{"key":"2025032411293715500_r37","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.4049\/jimmunol.174.11.6592","article-title":"Cutting edge: generation of splenic CD8+ and CD8\u2212 dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures","volume":"174","author":"Naik","year":"2005","journal-title":"J. Immunol."},{"key":"2025032411293715500_r38","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V99.6.2084","article-title":"Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression","volume":"99","author":"McLellan","year":"2002","journal-title":"Blood"},{"key":"2025032411293715500_r39","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2025032411293715500_r40","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.177.1.372","article-title":"Signal regulatory protein molecules are differentially expressed by CD8\u2212 dendritic cells","volume":"177","author":"Lahoud","year":"2006","journal-title":"J. Immunol."},{"key":"2025032411293715500_r41","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.4049\/jimmunol.174.5.2573","article-title":"IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity","volume":"174","author":"Tamura","year":"2005","journal-title":"J. Immunol."},{"key":"2025032411293715500_r42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ni903","article-title":"Transcriptional profiling identifies Id2 function in dendritic cell development","volume":"4","author":"Hacker","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025032411293715500_r43","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/eji.200838470","article-title":"Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B","volume":"38","author":"Nagasawa","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2025032411293715500_r44","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1182\/blood.V87.12.5225.bloodjournal87125225","article-title":"Id2 expression increases with differentiation of human myeloid cells","volume":"87","author":"Ishiguro","year":"1996","journal-title":"Blood"},{"key":"2025032411293715500_r45","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/icb.2008.63","article-title":"Distinct functional capacities of mouse thymic and splenic dendritic cell populations","volume":"86","author":"Proietto","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"2025032411293715500_r46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/eji.200323797","article-title":"Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8\u03b1+ DC correlates with unresponsiveness to imidazoquinolines","volume":"33","author":"Edwards","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2025032411293715500_r47","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.4049\/jimmunol.166.9.5448","article-title":"Differential production of IL-12, IFN-\u03b1, and IFN-\u03b3 by mouse dendritic cell subsets","volume":"166","author":"Hochrein","year":"2001","journal-title":"J. Immunol."},{"key":"2025032411293715500_r48","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1074-7613(00)00045-5","article-title":"CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal","volume":"13","author":"Schulz","year":"2000","journal-title":"Immunity"},{"key":"2025032411293715500_r49","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.4049\/jimmunol.169.7.3652","article-title":"Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering","volume":"169","author":"Edwards","year":"2002","journal-title":"J. Immunol."},{"key":"2025032411293715500_r50","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/intimm\/10.11.1593","article-title":"High-level IL-12 production by human dendritic cells requires two signals","volume":"10","author":"Snijders","year":"1998","journal-title":"Int. Immunol."},{"key":"2025032411293715500_r51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/intimm\/dxh382","article-title":"The proliferative response of CD4 T cells to steady-state CD8+ dendritic cells is restricted by post-activation death","volume":"18","author":"Rizzitelli","year":"2006","journal-title":"Int. Immunol."},{"key":"2025032411293715500_r52","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1365-2249.1998.00617.x","article-title":"Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy","volume":"112","author":"Fingerle-Rowson","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"2025032411293715500_r53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/CCLM.1999.039","article-title":"CD14++ monocytes, CD14+\/CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy","volume":"37","author":"Scherberich","year":"1999","journal-title":"Clin. Chem. Lab. Med."},{"key":"2025032411293715500_r54","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/01.TP.0000066351.87480.9E","article-title":"Pulmonary transplantation: the role of brain death in donor lung injury","volume":"75","author":"Avlonitis","year":"2003","journal-title":"Transplantation"},{"key":"2025032411293715500_r55","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.transproceed.2007.01.052","article-title":"Innate immunity-mediated allograft rejection and strategies to prevent it","volume":"39","author":"Land","year":"2007","journal-title":"Transplant. Proc."},{"key":"2025032411293715500_r56","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.192.6.823","article-title":"Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells","volume":"192","author":"Hochrein","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032411293715500_r57","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1182\/blood-2004-08-3105","article-title":"Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery","volume":"105","author":"Schnurr","year":"2005","journal-title":"Blood"},{"key":"2025032411293715500_r58","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.immuni.2008.09.002","article-title":"Antigen-presentation properties of plasmacytoid dendritic cells","volume":"29","author":"Villadangos","year":"2008","journal-title":"Immunity"},{"key":"2025032411293715500_r59","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/icb.2008.14","article-title":"Monocyte-derived dendritic cells in innate and adaptive immunity","volume":"86","author":"Le\u00f3n","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"2025032411293715500_r60","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.4049\/jimmunol.0903793","article-title":"Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways","volume":"185","author":"Zhan","year":"2010","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/11\/6207\/61733960\/1002632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/11\/6207\/61733960\/1002632.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T18:44:22Z","timestamp":1743187462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/186\/11\/6207\/7996709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1002632","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,6]]},"published":{"date-parts":[[2011,6,1]]}}}