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To investigate the immune potential of MHC class Ib-restricted CD8+ T cells, we have generated mice that lack both MHC class Ia and H2-M3 molecules (Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212). The CD8+ T cells present in Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 mice display an activated surface phenotype and are able to secrete IFN-\u03b3 rapidly upon anti-CD3 and anti-CD28 stimulation. Although the CD8+ T cell population is reduced in Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 mice compared with that in Kb\u2212\/\u2212D b\u2212\/\u2212 mice, this population retains the capacity to expand significantly in response to primary infection with the bacteria Listeria monocytogenes. However, Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 CD8+ T cells do not expand upon secondary infection, similar to what has been observed for H2-M3\u2013restricted T cells. CD8+ T cells isolated from Listeria-infected Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 mice exhibit cytotoxicity and secrete proinflammatory cytokines in response to Listeria-infected APCs. These T cells are protective against primary Listeria infection, as Listeria-infected Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 mice exhibit reduced bacterial burden compared with that of infected \u03b22-microglobulin\u2013deficient mice that lack MHC class Ib-restricted CD8+ T cells altogether. In addition, adoptive transfer of Listeria-experienced Kb\u2212\/\u2212D b\u2212\/\u2212M3\u2212\/\u2212 splenocytes protects recipient mice against subsequent Listeria infection in a CD8+ T cell-dependent manner. These data demonstrate that other MHC class Ib-restricted CD8+ T cells, in addition to H2-M3\u2013restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria.<\/jats:p>","DOI":"10.4049\/jimmunol.1002639","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T05:24:36Z","timestamp":1290489876000},"page":"489-498","source":"Crossref","is-referenced-by-count":15,"title":["Nonconventional CD8+ T Cell Responses to <i>Listeria<\/i> Infection in Mice Lacking MHC Class Ia and H2-M3"],"prefix":"10.1093","volume":"186","author":[{"given":"Hoonsik","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak-Jong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyrie","family":"Felio","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyung-Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University , Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2025032410572203800_r1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nri1635","article-title":"MHC class Ib molecules bridge innate and acquired immunity","volume":"5","author":"Rodgers","year":"2005","journal-title":"Nat. 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