{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:15:12Z","timestamp":1773288912788,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Monocytes and macrophages are targets of HIV-1 infection and play critical roles in multiple aspects of viral pathogenesis. During the differentiation of monocytes to macrophages, adhesion molecules such as integrins are upregulated; therefore, they provide signals that control the process and subsequently may render macrophages more susceptible to HIV-1 infection. Previous work demonstrated that blocking \u03b1v-containing integrins triggered a signal transduction pathway leading to the inhibition of NF-\u03baB\u2013dependent HIV-1 transcription. In this paper, we show the influence of the different \u03b1v-coupled \u03b2 integrins in HIV-1 replication in macrophages. Inhibition of \u03b2 integrins, either by specific mAbs, small arginine-glycine-aspartic acid (RGD) mimetic compounds, or RNA interference, showed that integrin \u03b25 was the major contributor to the integrin-mediated blockade of HIV-1 replication. Importantly, such inhibition did not induce changes in cell adhesion to the substrate. In conclusion, our results reveal a significant role of the integrin dimmer \u03b1v\u03b25 in HIV-1 infection of macrophages.<\/jats:p>","DOI":"10.4049\/jimmunol.1002693","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T05:24:36Z","timestamp":1290489876000},"page":"464-470","source":"Crossref","is-referenced-by-count":21,"title":["\u03b25 Integrin Is the Major Contributor to the \u03b1v Integrin-Mediated Blockade of HIV-1 Replication"],"prefix":"10.1093","volume":"186","author":[{"given":"Ester","family":"Ballana","sequence":"first","affiliation":[{"name":"IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona , Badalona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Pauls","sequence":"additional","affiliation":[{"name":"IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona , Badalona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonaventura","family":"Clotet","sequence":"additional","affiliation":[{"name":"IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona , Badalona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Perron-Sierra","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Servier Research Institute , Croissy sur Seine ,","place":["France"]},{"name":"Department of Cancer Research and Drug Discovery, Servier Research Institute , Croissy sur Seine ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Servier Research Institute , Croissy sur Seine ,","place":["France"]},{"name":"Department of Cancer Research and Drug Discovery, Servier Research Institute , Croissy sur Seine ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Est\u00e9","sequence":"additional","affiliation":[{"name":"IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona , Badalona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"2025032410562250400_r1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.iy.08.040190.001125","article-title":"Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection","volume":"8","author":"Meltzer","year":"1990","journal-title":"Annu. 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