{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:04:22Z","timestamp":1774343062934,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human peripheral blood BCR\u03bc+ B cells express high levels of CD23 and circulate preloaded with IgE. The Ag specificity of CD23-bound IgE presumably differs from the BCR and likely reflects the Ag-specific mix of free serum IgE. CD23-bound IgE is thought to enhance B cell Ag presentation to T cells raising the question of how a B cell might respond when presented with a broad mix of Ags and CD23-bound IgE specificities. We recently reported that an increase in CD23+ B cells is associated with the development of resistance to schistosomiasis, highlighting the potential importance of CD23-bound IgE in mediating immunity. We sought to determine the relationship between BCR and CD23-bound IgE-mediated B cell activation in the context of schistosomiasis. We found that crude schistosome Ags downregulate basal B cell activation levels in individuals hyperexposed to infectious worms. Schistosome-specific IgE from resistant, occupationally exposed Kenyans recovered responses of B cells to schistosome Ag. Furthermore, cross-linking of CD23 overrode intracellular signals mediated via the BCR, illustrating its critical and dominating role in B cell activation. These results suggest that CD23-bound IgE augments and dominates recall responses through naive B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1002709","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T05:31:21Z","timestamp":1292477481000},"page":"1060-1067","source":"Crossref","is-referenced-by-count":18,"title":["CD23-Bound IgE Augments and Dominates Recall Responses through Human Naive B Cells"],"prefix":"10.1093","volume":"186","author":[{"given":"Qyana K","family":"Griffith","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanMei","family":"Liang","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel O","family":"Onguru","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Kenya Medical Research Institute , Kisumu, 40100 ,","place":["Kenya"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline N","family":"Mwinzi","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Kenya Medical Research Institute , Kisumu, 40100 ,","place":["Kenya"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M","family":"Ganley-Leal","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston Medical Center , Boston, MA 02118"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,15]]},"reference":[{"key":"2025032411005311500_r1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/eji.1830220622","article-title":"Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection","volume":"22","author":"Dunne","year":"1992","journal-title":"Eur. 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