{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:30:12Z","timestamp":1792121412147,"version":"4.4.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High-grade cervical dysplasia caused by human papillomavirus (HPV) type 16 is a lesion that should be susceptible to an HPV-specific immune response; disease initiation and persistence is predicated on expression of two viral Ags, E6 and E7. In immune-competent subjects, at least 25% of HPV16+ high-grade cervical dysplasia lesions undergo complete regression. However, in the peripheral blood, naturally occurring IFN-\u03b3 T cell responses to HPV E6 and E7 are weak, requiring ex vivo sensitization to detect, and are not sufficiently sensitive to predict regression. In this study, we present immunologic data directly assessing cervical lymphocytes from this cohort. We found that nearly all cervical tissue T cells express the mucosal homing receptor, \u03b14\u03b27 surface integrin. T cells isolated from dysplastic mucosa were skewed toward a central memory phenotype compared with normal mucosal resident T cells, and dysplastic lesions expressed transcripts for CCL19 and CCL21, raising the possibility that the tissue itself sustains a response that is not detectable in the blood. Moreover, lesion regression in the study window could retrospectively be predicted at study entry by the ability of CD8+ T cells to gain access to lesional epithelium. Vascular endothelial expression of mucosal addressin cell adhesion molecule-1, the ligand that supports entry of \u03b14\u03b27+ T cells into tissues, colocalized tightly with the distribution of CD8 T cells and was not expressed in persistent dysplastic epithelium. These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1002756","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T23:06:24Z","timestamp":1288393584000},"page":"7107-7114","source":"Crossref","is-referenced-by-count":114,"title":["Human Papillomavirus 16-Associated Cervical Intraepithelial Neoplasia in Humans Excludes CD8 T Cells from Dysplastic Epithelium"],"prefix":"10.1093","volume":"185","author":[{"given":"Cornelia L","family":"Trimble","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, MD 21287"},{"name":"Department of Oncology, Johns Hopkins University School of Medicine , Baltimore, MD 21287"},{"name":"Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women\u2019s Hospital, Boston , MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Thoburn","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine , Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C","family":"Hanson","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Tassello","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Frosina","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdynand","family":"Kos","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine , Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Teague","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women\u2019s Hospital, Boston , MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women\u2019s Hospital, Boston , MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C","family":"Barat","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim A","family":"Jungbluth","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"2025032412112711300_r1","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1002\/eji.200737820","article-title":"Prevention of cancer through immunization: Prospects and challenges for the 21st century","volume":"37","author":"Frazer","year":"2007","journal-title":"Eur. 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