{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:43:34Z","timestamp":1791020614055,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In addition to the well-described role of platelets in thrombosis, a growing body of evidence implicates platelets in diverse inflammatory responses. We recently showed platelets can contribute to the pathophysiology of inflammatory arthritis via IL-1\u2013 containing microparticles. In this study, we demonstrate that platelets, and not platelet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin in an autoimmune arthritis model. Using both genetic and pharmacologic approaches, we establish that paracrine production of prostacyclin proceeds in the absence of cyclooxygenase-2. Furthermore, we also demonstrate that prostacyclin generation can arise via transcellular collaboration between platelets and fibroblast-like synoviocytes. In addition to shedding light on an unappreciated pathway of lipid synthesis in arthritis, we further delineate a novel effector activity by which platelets can contribute to inflammatory disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1002857","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T16:11:07Z","timestamp":1298995867000},"page":"4361-4366","source":"Crossref","is-referenced-by-count":40,"title":["Platelets Participate in Synovitis via Cox-1\u2013Dependent Synthesis of Prostacyclin Independently of Microparticle Generation"],"prefix":"10.1093","volume":"186","author":[{"given":"Eric","family":"Boilard","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"},{"name":"Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 Laval , Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Larabee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Shnayder","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W","family":"Farndale","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge , Downing Site, Cambridge CB2 1QW ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Ware","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences , Little Rock, AR 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"},{"name":"Novartis Pharma , Basel 4056 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"2025032411185152200_r1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(00)02175-9","article-title":"Platelets","volume":"355","author":"George","year":"2000","journal-title":"Lancet"},{"key":"2025032411185152200_r2","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N. 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