{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:15:46Z","timestamp":1780485346972,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Con A-induced hepatitis has been used as a model of human autoimmune or viral hepatitis. During the process of identifying immunologically bioactive proteins in human plasma, we found that apolipoprotein A-II (ApoA-II), the second major apolipoprotein of high-density lipoprotein, inhibited the production of IFN-\u03b3 by Con A-stimulated mouse and human CD4 T cells. Con A-induced hepatitis was attenuated by the administration of ApoA-II. The beneficial effect of ApoA-II was associated with reduced leukocyte infiltration and decreased production of T cell-related cytokines and chemokines in the liver. ApoA-II inhibited the Con A-induced activation of ERK\u2013MAPK and nuclear translocation of NFAT in CD4 T cells. Interestingly, exacerbated hepatitis was observed in ApoA-II\u2013deficient mice, indicating that ApoA-II plays a suppressive role in Con A-induced hepatitis under physiological conditions. Moreover, the administration of ApoA-II after the onset of Con A-induced hepatitis was sufficient to suppress disease. Thus, the therapeutic effect of ApoA-II could be useful for patients with CD4 T cell-related autoimmune and viral hepatitis.<\/jats:p>","DOI":"10.4049\/jimmunol.1002924","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T05:34:39Z","timestamp":1297143279000},"page":"3410-3420","source":"Crossref","is-referenced-by-count":28,"title":["Apolipoprotein A-II Suppressed Concanavalin A-Induced Hepatitis via the Inhibition of CD4 T Cell Function"],"prefix":"10.1093","volume":"186","author":[{"given":"Junji","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 ,","place":["Japan"]},{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Iwamura","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 ,","place":["Japan"]},{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunitoshi","family":"Mitsumori","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology , Tokyo 183-8509 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Hada","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Hara","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kaneshiro","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Laboratory, Research Division, Nihon Pharmaceutical Co., Ltd. , Narita-City, Chiba 286-0825 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"2025032411143132600_r1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J. Hepatol."},{"key":"2025032411143132600_r2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hep.510250308","article-title":"Autoimmune hepatitis in childhood: a 20-year experience","volume":"25","author":"Gregorio","year":"1997","journal-title":"Hepatology"},{"key":"2025032411143132600_r3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncpgasthep0768","article-title":"Current therapy for autoimmune hepatitis","volume":"4","author":"Montano Loza","year":"2007","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"2025032411143132600_r4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/jhep.2002.30991","article-title":"Current and novel immunosuppressive therapy for autoimmune hepatitis","volume":"35","author":"Heneghan","year":"2002","journal-title":"Hepatology"},{"key":"2025032411143132600_r5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1590-8658(00)80266-2","article-title":"Virus, liver and autoimmunity","volume":"32","author":"Bogdanos","year":"2000","journal-title":"Dig. Liver Dis."},{"key":"2025032411143132600_r6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/jhep.2001.21162","article-title":"Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection","volume":"33","author":"Chang","year":"2001","journal-title":"Hepatology"},{"key":"2025032411143132600_r7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0016-5085(93)90034-A","article-title":"Cell-mediated hepatic injury in alcoholic liver disease. Veterans Affairs Cooperative Study Group 275","volume":"105","author":"Chedid","year":"1993","journal-title":"Gastroenterology"},{"key":"2025032411143132600_r8","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/gast.2001.22441","article-title":"The lymphoid liver: considerations on pathways to autoimmune injury","volume":"120","author":"Kita","year":"2001","journal-title":"Gastroenterology"},{"key":"2025032411143132600_r9","first-page":"299","article-title":"Cell mediated immune response to the hepatitis C virus","volume":"242","author":"Rehermann","year":"2000","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025032411143132600_r10","first-page":"17","article-title":"Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis","volume":"50","author":"Eggink","year":"1982","journal-title":"Clin. Exp. Immunol."},{"key":"2025032411143132600_r11","first-page":"1416","article-title":"Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis","volume":"24","author":"L\u00f6hr","year":"1996","journal-title":"Hepatology"},{"key":"2025032411143132600_r12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2025032411143132600_r13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"K\u00fcsters","year":"1996","journal-title":"Gastroenterology"},{"key":"2025032411143132600_r14","first-page":"1608","article-title":"Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis","volume":"23","author":"Mizuhara","year":"1996","journal-title":"Hepatology"},{"key":"2025032411143132600_r15","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1073\/pnas.91.2.614","article-title":"Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver","volume":"91","author":"Toyonaga","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411143132600_r16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.191.1.105","article-title":"Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis","volume":"191","author":"Kaneko","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025032411143132600_r17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0002-8703(87)90638-7","article-title":"Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis","volume":"113","author":"Miller","year":"1987","journal-title":"Am. Heart J."},{"key":"2025032411143132600_r18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1172\/JCI114722","article-title":"Plasma high density lipoproteins. Metabolism and relationship to atherogenesis","volume":"86","author":"Tall","year":"1990","journal-title":"J. Clin. Invest."},{"key":"2025032411143132600_r19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/BF00201563","article-title":"Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci","volume":"93","author":"Bu","year":"1994","journal-title":"Hum. Genet."},{"key":"2025032411143132600_r20","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1128\/MCB.16.7.3350","article-title":"Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor","volume":"16","author":"Vu-Dac","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"2025032411143132600_r21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1172\/JCI119554","article-title":"Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles","volume":"100","author":"Castellani","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2025032411143132600_r22","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1194\/jlr.M800578-JLR200","article-title":"Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I","volume":"50","author":"Alexander","year":"2009","journal-title":"J. Lipid Res."},{"key":"2025032411143132600_r23","doi-asserted-by":"crossref","first-page":"14788","DOI":"10.1073\/pnas.93.25.14788","article-title":"Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility","volume":"93","author":"Weng","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411143132600_r24","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S0022-2275(20)33510-0","article-title":"ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice","volume":"40","author":"Weng","year":"1999","journal-title":"J. Lipid Res."},{"key":"2025032411143132600_r25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1172\/JCI101508","article-title":"Chemical, clinical, and immunological studies on the products of human plasma fractionation. I. The characterization of the protein fractions of human plasma","volume":"23","author":"Cohn","year":"1944","journal-title":"J. Clin. Invest."},{"key":"2025032411143132600_r26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0003-2697(89)90642-8","article-title":"A purification method for apolipoprotein A-I and A-II","volume":"178","author":"Peitsch","year":"1989","journal-title":"Anal. Biochem."},{"key":"2025032411143132600_r27","doi-asserted-by":"crossref","first-page":"38029","DOI":"10.1074\/jbc.M206626200","article-title":"Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid","volume":"277","author":"Yang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025032411143132600_r28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1084\/jem.20040733","article-title":"Regulation of T helper type 2 cell differentiation by murine Schnurri-2","volume":"201","author":"Kimura","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025032411143132600_r29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-1759(90)90407-M","article-title":"Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver","volume":"132","author":"Goossens","year":"1990","journal-title":"J. Immunol. Methods"},{"key":"2025032411143132600_r30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0022-1759(92)90223-G","article-title":"Details of an isolation method for hepatic lymphocytes in mice","volume":"146","author":"Watanabe","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"2025032411143132600_r31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(01)00182-0","article-title":"Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene","volume":"15","author":"Kimura","year":"2001","journal-title":"Immunity"},{"key":"2025032411143132600_r32","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.96.3.1024","article-title":"T cell antigen receptor-mediated activation of the Ras\/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation","volume":"96","author":"Yamashita","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032411143132600_r33","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/eji.200425071","article-title":"CCL3\/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver","volume":"34","author":"Ajuebor","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2025032411143132600_r34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/path.1298","article-title":"Early up-regulation of chemokine expression in fulminant hepatic failure","volume":"199","author":"Leifeld","year":"2003","journal-title":"J. Pathol."},{"key":"2025032411143132600_r35","first-page":"190","article-title":"Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"2025032411143132600_r36","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","article-title":"Suppression of concanavalin A-induced hepatitis in IFN-gamma(-\/-) mice, but not in TNF-alpha(-\/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes","volume":"159","author":"Tagawa","year":"1997","journal-title":"J. Immunol."},{"key":"2025032411143132600_r37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1006\/bbrc.1999.0276","article-title":"IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes","volume":"257","author":"Kano","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025032411143132600_r38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4049\/jimmunol.172.1.45","article-title":"Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis","volume":"172","author":"Bonder","year":"2004","journal-title":"J. Immunol."},{"key":"2025032411143132600_r39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/excr.1996.0351","article-title":"T cell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release","volume":"229","author":"Gantner","year":"1996","journal-title":"Exp. Cell Res."},{"key":"2025032411143132600_r40","first-page":"20","article-title":"Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin","volume":"119","author":"Bournazou","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025032411143132600_r41","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.181.11.7473","article-title":"Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells","volume":"181","author":"Nagata","year":"2008","journal-title":"J. Immunol."},{"key":"2025032411143132600_r42","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.4049\/jimmunol.158.11.5536","article-title":"Expression of IFN-inducible protein-10 in chronic hepatitis","volume":"158","author":"Narumi","year":"1997","journal-title":"J. Immunol."},{"key":"2025032411143132600_r43","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.163.11.6236","article-title":"Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver","volume":"163","author":"Shields","year":"1999","journal-title":"J. Immunol."},{"key":"2025032411143132600_r44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/labinvest.3780046","article-title":"Expression of C-C chemokines is associated with portal and periportal inflammation in the liver of patients with chronic hepatitis C","volume":"80","author":"Kusano","year":"2000","journal-title":"Lab. Invest."},{"key":"2025032411143132600_r45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<82::AID-PATH151>3.0.CO;2-D","article-title":"Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis","volume":"186","author":"Afford","year":"1998","journal-title":"J. Pathol."},{"key":"2025032411143132600_r46","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00007890-199603150-00024","article-title":"Hepatic expression of macrophage inflammatory protein-1 alpha and macrophage inflammatory protein-1 beta after liver transplantation","volume":"61","author":"Adams","year":"1996","journal-title":"Transplantation"},{"key":"2025032411143132600_r47","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1111\/j.1432-2277.2000.tb02007.x","article-title":"RANTES in the postoperative course after liver transplantation","volume":"13","author":"Schenk","year":"2000","journal-title":"Transpl. Int."},{"key":"2025032411143132600_r48","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.4049\/jimmunol.174.12.8027","article-title":"Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells","volume":"174","author":"Ajuebor","year":"2005","journal-title":"J. Immunol."},{"key":"2025032411143132600_r49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2004.08.012","article-title":"Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases","volume":"21","author":"Diao","year":"2004","journal-title":"Immunity"},{"key":"2025032411143132600_r50","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/1074-7613(95)90028-4","article-title":"Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene","volume":"2","author":"Rooney","year":"1995","journal-title":"Immunity"},{"key":"2025032411143132600_r51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60618-5","article-title":"NF-kappa B and rel proteins in innate immunity","volume":"58","author":"Kopp","year":"1995","journal-title":"Adv. Immunol."},{"key":"2025032411143132600_r52","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0167-5699(94)90007-8","article-title":"NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes","volume":"15","author":"Rao","year":"1994","journal-title":"Immunol. Today"},{"key":"2025032411143132600_r53","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the NFAT family: regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2025032411143132600_r54","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jhep.2004.01.009","article-title":"Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis","volume":"40","author":"Czaja","year":"2004","journal-title":"J. Hepatol."},{"key":"2025032411143132600_r55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1749-6632.1993.tb17167.x","article-title":"Immunosuppressive treatment of chronic liver disease","volume":"696","author":"Jones","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/6\/3410\/61696167\/1002924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/186\/6\/3410\/61696167\/1002924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T12:29:14Z","timestamp":1743164954000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/186\/6\/3410\/7990139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,3,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1002924","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,3]]},"published":{"date-parts":[[2011,3]]}}}