{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:32:57Z","timestamp":1773203577269,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Donor-reactive memory T cells (Tmem) can play an important role in mediating graft rejection after transplantation. Transplant recipients acquire donor-reactive Tmem not only through prior sensitization with alloantigens but also through previous exposure to environmental pathogens that are cross-reactive with allogeneic peptide\u2013MHC complexes. Current dogma suggests that most, if not all, Tmem responses are independent of the requirement for CD28 and\/or CD154\/CD40-mediated costimulation to mount a recall response. However, heterogeneity among Tmem is increasingly being appreciated, and one important factor known to impact the function and phenotype of Ag-specific T cell responses is the amount\/duration of Ag exposure. Importantly, the impact of Ag exposure on development of costimulation independence is currently unknown. In this study, we interrogated the effect of decreased Ag amount\/duration during priming on the ability of donor-reactive Tmem to mediate costimulation blockade-resistant rejection during a recall response after transplantation in a murine model. Recipients possessing donor-reactive Tmem responses that were generated under conditions of reduced Ag exposure exhibited similar frequencies of Ag-specific T cells at day 30 postinfection, but, strikingly, failed to mediate costimulation blockade-resistant rejection after challenge with an OVA-expressing skin graft. Thus, these data demonstrate the amount\/duration of Ag exposure is a critical factor in determining Tmem\u2019s relative requirement for costimulation during the recall response after transplantation.<\/jats:p>","DOI":"10.4049\/jimmunol.1003015","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T04:06:05Z","timestamp":1295669165000},"page":"2033-2041","source":"Crossref","is-referenced-by-count":27,"title":["Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall"],"prefix":"10.1093","volume":"186","author":[{"given":"Tamara L","family":"Floyd","sequence":"first","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent H","family":"Koehn","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H","family":"Kitchens","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A","family":"Cheeseman","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Stempora","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian P","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy L","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University , Atlanta, GA 30322"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"2025032411064975000_r1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2009.11.007","article-title":"Diversity in T cell memory: an embarrassment of riches","volume":"31","author":"Jameson","year":"2009","journal-title":"Immunity"},{"key":"2025032411064975000_r2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri2496","article-title":"Migration, maintenance and recall of memory T cells in peripheral tissues","volume":"9","author":"Woodland","year":"2009","journal-title":"Nat. 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