{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T20:58:05Z","timestamp":1788037085699,"version":"build-2784847793"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of Fc\u03b5RI-bound allergen-specific IgE. However, recent reports established that anaphylaxis could also be triggered by basophil, macrophage, and neutrophil secretion of platelet-activating factor subsequent to Fc\u03b3R stimulation by IgG\/Ag complexes. We have investigated the contribution of Fyn and Lyn tyrosine kinases to Fc\u03b3RIIb and Fc\u03b3RIII signaling in the context of IgG-mediated passive systemic anaphylaxis (PSA). We found that mast cell IgG XL induced Fyn, Lyn, Akt, Erk, p38, and JNK phosphorylation. Additionally, IgG XL of mast cells, basophils, and macrophages resulted in Fyn- and Lyn-regulated mediator release in vitro. Fc\u03b3R-mediated activation was enhanced in Lyn-deficient (knockout [KO]) cells, but decreased in Fyn KO cells, compared with wild-type cells. More importantly, Lyn KO mice displayed significantly exacerbated PSA features whereas no change was observed for Fyn KO mice, compared with wild-type littermates. Intriguingly, we establish that mast cells account for most serum histamine in IgG-induced PSA. Taken together, our findings establish pivotal roles for Fyn and Lyn in the regulation of PSA and highlight their unsuspected functions in IgG-mediated pathologies.<\/jats:p>","DOI":"10.4049\/jimmunol.1003223","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T04:34:27Z","timestamp":1332822867000},"page":"4360-4368","source":"Crossref","is-referenced-by-count":26,"title":["Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis"],"prefix":"10.1093","volume":"188","author":[{"given":"Yves T","family":"Falanga","sequence":"first","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia S","family":"Chaimowitz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Charles","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 699, \u201cImmunopathologie R\u00e9nale, R\u00e9cepteurs et Inflammation,\u201d Facult\u00e9 de M\u00e9decine Xavier Bichat\u2013Universit\u00e9 Paris VII Denis Diderot , 75870 Paris Cedex 18 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Research Service, Cincinnati Veterans Affairs Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A","family":"Pullen","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Barbour","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Dholaria","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motunrayo","family":"Kolawole","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Odom","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rivera","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Carlyon","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole A","family":"Oskeritzian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine , Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Biology, Virginia Commonwealth University , Richmond, VA 23284"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"2025032410052893200_r1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat. 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