{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:14:48Z","timestamp":1792127688812,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dermatitis herpetiformis (DH) is characterized by deposition of IgA in the papillary dermis. However, indirect immunofluorescence is routinely negative, raising the question of the mechanism of formation of these immune deposits. S\u00e1rdy et al. (2002. J. Exp. Med. 195: 747\u2013757) reported that transglutaminase-3 (TG3) colocalizes with the IgA. We sought to create such deposits using passive transfer of Ab to SCID mice bearing human skin grafts. IgG fraction of goat anti-TG3 or control IgG were administered i.p. to 20 mice. Separately, sera from seven DH patients and seven controls were injected intradermally. Biopsies were removed and processed for routine histology as well as direct immunofluorescence. All mice that received goat anti-TG3 produced papillary dermal immune deposits, and these deposits reacted with both rabbit anti-TG3 and DH patient sera. Three DH sera high in IgA anti-TG3 also produced deposits of granular IgA and TG3. We hypothesize that the IgA class anti-TG3 Abs are directly responsible for the immune deposits and that the TG3 is from human epidermis, as this is its only source in our model. These deposits seem to form over weeks in a process similar to an Ouchterlony immunodiffusion precipitate. This process of deposition explains the negative indirect immunofluorescence results with DH serum.<\/jats:p>","DOI":"10.4049\/jimmunol.1003273","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T22:40:35Z","timestamp":1298068835000},"page":"4474-4480","source":"Crossref","is-referenced-by-count":56,"title":["Dermatitis Herpetiformis Sera or Goat Anti\u2013Transglutaminase-3 Transferred to Human Skin-Grafted Mice Mimics Dermatitis Herpetiformis Immunopathology"],"prefix":"10.1093","volume":"186","author":[{"given":"John J","family":"Zone","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"},{"name":"Salt Lake City Department of Veterans Affairs Medical Center , Salt Lake City, UT 84148"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted B","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"},{"name":"Salt Lake City Department of Veterans Affairs Medical Center , Salt Lake City, UT 84148"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Hull","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Sotiriou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy D","family":"Jaskowski","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Pathology, ARUP Laboratories , Salt Lake City, UT 84108"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry R","family":"Hill","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Pathology, ARUP Laboratories , Salt Lake City, UT 84108"},{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"},{"name":"Department of Pediatrics, University of Utah , Salt Lake City, UT 84112"},{"name":"Department of Internal Medicine, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence J","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, UT 84112"},{"name":"Salt Lake City Department of Veterans Affairs Medical Center , Salt Lake City, UT 84148"},{"name":"Department of Internal Medicine, University of Utah , Salt Lake City, UT 84112"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"issue":"4","key":"2025032411190326100_r1","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/j.gastro.2005.02.026","article-title":"Skin manifestations of celiac disease","volume":"128","author":"Zone","year":"2005","journal-title":"Gastroenterology"},{"key":"2025032411190326100_r2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/archderm.1996.03890320060010","article-title":"Deposition of granular IgA relative to clinical lesions in dermatitis herpetiformis","volume":"132","author":"Zone","year":"1996","journal-title":"Arch. 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