{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:46:57Z","timestamp":1791092817310,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although the induction mechanism of secretory IgA has been well studied, that of IgG in the mucosal compartments is not well understood. In this study, vitamin A deficiency was convincingly shown to be associated with increased IgG in serum and intestinal fluid. We found increased numbers of IgG-secreting B cells in the lamina propria of the small intestine and mesenteric lymph node (MLN) of vitamin A-deficient (VAD) mice. Of note, IFN-\u03b3 secreted by MLN dendritic cells (DCs) was significantly augmented in VAD mice, unlike control mice, and CD103+ DCs were the main subsets to secrete IFN-\u03b3. The aberrant increase of IgG in VAD mice can be ascribable to IFN-\u03b3, because IFN-\u03b3\u2212\/\u2212 VAD mice have normal IgG levels and the addition of rIFN-\u03b3 increased IgG production by B cells cocultured with MLN DCs from IFN-\u03b3\u2212\/\u2212 VAD mice. Oral feeding of antibiotics resulted in significant reduction of IgG in VAD mice, indicating a critical role for altered commensal bacteria for IgG class-switching recombination in the absence of vitamin A. Collectively, vitamin A deficiency provokes the generation of IFN-\u03b3\u2013secreting CD103+ DCs, which may be a critical regulator for IgG generation in the MLN.<\/jats:p>","DOI":"10.4049\/jimmunol.1003484","type":"journal-article","created":{"date-parts":[[2011,5,14]],"date-time":"2011-05-14T03:16:31Z","timestamp":1305342991000},"page":"6999-7005","source":"Crossref","is-referenced-by-count":9,"title":["IFN-\u03b3 Secreted by CD103+ Dendritic Cells Leads to IgG Generation in the Mesenteric Lymph Node in the Absence of Vitamin A"],"prefix":"10.1093","volume":"186","author":[{"given":"Jae-Hoon","family":"Chang","sequence":"first","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ran","family":"Cha","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jeong","family":"Ko","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]},{"name":"Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University , Chuncheon 200-701 ,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Uk","family":"Seo","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Na","family":"Kweon","sequence":"additional","affiliation":[{"name":"Mucosal Immunology Section, International Vaccine Institute , Seoul ,","place":["South Korea 151-818"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"2025032411332182600_r1","first-page":"831","volume-title":"Fundamental Immunology.","author":"Snapper","year":"1999"},{"key":"2025032411332182600_r2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1084\/jem.177.4.1031","article-title":"Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells","volume":"177","author":"McIntyre","year":"1993","journal-title":"J. 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