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In this study, we demonstrate this by observing that autoimmune type 1 diabetes-protective haplotypes at the insulin-dependent diabetes susceptibility region 10 (Idd10) introgressed from chromosome 3 of C57BL\/6 (B6) and A\/J mice onto the NOD background increase the severity of autoimmune primary biliary cirrhosis induced by infection with Novosphingobium aromaticivorans, a ubiquitous alphaproteobacterium, when compared with mice having the NOD and NOD.CAST Idd10 type 1 diabetes-susceptible haplotypes. Substantially increased liver pathology in mice having the B6 and A\/J Idd10 haplotypes correlates with reduced expression of CD101 on dendritic cells, macrophages, and granulocytes following infection, delayed clearance of N. aromaticivorans, and the promotion of overzealous IFN-\u03b3\u2013 and IL-17\u2013dominated T cell responses essential for the adoptive transfer of liver lesions. CD101-knockout mice generated on the B6 background also exhibit substantially more severe N. aromaticivorans-induced liver disease correlating with increased IFN-\u03b3 and IL-17 responses compared with wild-type mice. These data strongly support the hypothesis that allelic variation of the Cd101 gene, located in the Idd10 region, alters the severity of liver autoimmunity induced by N. aromaticivorans.<\/jats:p>","DOI":"10.4049\/jimmunol.1003525","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T03:08:14Z","timestamp":1306379294000},"page":"337-349","source":"Crossref","is-referenced-by-count":32,"title":["Identification of <i>Cd101<\/i> as a Susceptibility Gene for <i>Novosphingobium aromaticivorans<\/i>-Induced Liver Autoimmunity"],"prefix":"10.1093","volume":"187","author":[{"given":"Javid P","family":"Mohammed","sequence":"first","affiliation":[{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E","family":"Fusakio","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital , Cincinnati, OH 45229"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B","family":"Rainbow","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge CB2 0XY ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Moule","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge CB2 0XY ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather I","family":"Fraser","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge CB2 0XY ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Clark","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge CB2 0XY ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Todd","sequence":"additional","affiliation":[{"name":"Juvenile Diabetes Research Foundation\/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge , Cambridge CB2 0XY ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence 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