{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:36:02Z","timestamp":1792679762434,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>K\/BxN serum-induced passive arthritis was reported to depend on the activation of mast cells, triggered by the activating IgG receptor Fc\u03b3RIIIA, when engaged by IgG1 autoantibodies present in K\/BxN serum. This view is challenged by the fact that Fc\u03b3RIIIA-deficient mice still develop K\/BxN arthritis and because Fc\u03b3RIIIA is the only activating IgG receptor expressed by mast cells. We investigated the contribution of IgG receptors, IgG subclasses, and cells in K\/BxN arthritis. We found that the activating IgG2 receptor Fc\u03b3RIV, expressed only by monocytes\/macrophages and neutrophils, was sufficient to induce disease. K\/BxN arthritis occurred not only in mast cell-deficient Wsh mice, but also in mice whose mast cells express no activating IgG receptors. We propose that at least two autoantibody isotypes, IgG1 and IgG2, and two activating IgG receptors, Fc\u03b3RIIIA and Fc\u03b3RIV, contribute to K\/BxN arthritis, which requires at least two cell types other than mast cells, monocytes\/macrophages, and neutrophils.<\/jats:p>","DOI":"10.4049\/jimmunol.1003642","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T23:02:34Z","timestamp":1295478154000},"page":"1899-1903","source":"Crossref","is-referenced-by-count":90,"title":["Cutting Edge: The Murine High-Affinity IgG Receptor Fc\u03b3RIV Is Sufficient for Autoantibody-Induced Arthritis"],"prefix":"10.1093","volume":"186","author":[{"given":"David A","family":"Mancardi","sequence":"first","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Allergologie Mol\u00e9culaire et Cellulaire, D\u00e9partement d\u2019Immunologie , F-75015 Paris ,","place":["France"]},{"name":"INSERM, U760 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Allergologie Mol\u00e9culaire et Cellulaire, D\u00e9partement d\u2019Immunologie , F-75015 Paris ,","place":["France"]},{"name":"INSERM, U760 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Iannascoli","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Allergologie Mol\u00e9culaire et Cellulaire, D\u00e9partement d\u2019Immunologie , F-75015 Paris ,","place":["France"]},{"name":"INSERM, U760 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huot","family":"Khun","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Recherche et d\u2019Expertise Histotechnologie et Pathologie, D\u00e9partement de Pathologie , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Van Rooijen","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Vrije Universiteit Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Huerre","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Recherche et d\u2019Expertise Histotechnologie et Pathologie, D\u00e9partement de Pathologie , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Da\u00ebron","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Allergologie Mol\u00e9culaire et Cellulaire, D\u00e9partement d\u2019Immunologie , F-75015 Paris ,","place":["France"]},{"name":"INSERM, U760 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bruhns","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Allergologie Mol\u00e9culaire et Cellulaire, D\u00e9partement d\u2019Immunologie , F-75015 Paris ,","place":["France"]},{"name":"INSERM, U760 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"2025032411081046800_r1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/90696","article-title":"Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease","volume":"2","author":"Schaller","year":"2001","journal-title":"Nat. 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