{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:56:33Z","timestamp":1785408993625,"version":"3.56.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chagas\u2019 disease is a zoonosis prevalent in Latin America that is caused by the protozoan Trypanosoma cruzi. The immunopathogenesis of cardiomyopathy, the main clinical problem in Chagas\u2019 disease, has been extensively studied but is still poorly understood. In this study, we systematically compared clinical, microbiologic, pathologic, immunologic, and molecular parameters in two mouse models with opposite susceptibility to acute myocarditis caused by the myotropic Colombiana strain of T. cruzi: C3H\/HeSnJ (100% mortality, uncontrolled parasitism) and C57BL\/6J (&amp;lt;10% mortality, controlled parasitism). T. cruzi induced differential polarization of immunoregulatory cytokine mRNA expression in the hearts of C57BL\/6J versus C3H\/HeSnJ mice; however, most differences were small. The difference in IL-10 expression was exceptional (C57BL\/6J 8.7-fold greater than C3H\/HeSnJ). Consistent with this, hearts from infected C57BL\/6J mice, but not C3H\/HeSnJ mice, had a high frequency of total IL-10\u2013producing CD8+ T cells and both CD4+ and CD8+ subsets of IFN-\u03b3+IL-10+ double-producing T cells. Furthermore, T. cruzi infection of IL-10\u2212\/\u2212 C57BL\/6J mice phenocopied fatal infection in wild-type C3H\/HeSnJ mice with complete loss of parasite control. Adoptive transfer experiments indicated that T cells were a source of protective IL-10. Thus, in this system, IL-10 production by T cells promotes T. cruzi control and protection from fatal acute myocarditis.<\/jats:p>","DOI":"10.4049\/jimmunol.1003845","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T05:54:01Z","timestamp":1323755641000},"page":"649-660","source":"Crossref","is-referenced-by-count":80,"title":["IL-10 Limits Parasite Burden and Protects against Fatal Myocarditis in a Mouse Model of <i>Trypanosoma cruzi<\/i> Infection"],"prefix":"10.1093","volume":"188","author":[{"given":"Ester","family":"Roff\u00ea","sequence":"first","affiliation":[{"name":"Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Gigliotti","family":"Rothfuchs","sequence":"additional","affiliation":[{"name":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute , SE-171 77 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helton C","family":"Santiago","sequence":"additional","affiliation":[{"name":"Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula M P","family":"Marino","sequence":"additional","affiliation":[{"name":"Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia L","family":"Ribeiro-Gomes","sequence":"additional","affiliation":[{"name":"Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eckhaus","sequence":"additional","affiliation":[{"name":"Division of Veterinary Resources, Office of Research Services, Office of the Director, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis R V","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Laboratory of Immunopathology, Ren\u00e9 Rachou Research Center, Oswaldo Cruz Foundation , Belo Horizonte 30190-002, Minas Gerais ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M","family":"Murphy","sequence":"additional","affiliation":[{"name":"Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,15]]},"reference":[{"key":"2025032409444934200_r1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pt.2006.09.011","article-title":"The future of Chagas disease control","volume":"22","author":"Schofield","year":"2006","journal-title":"Trends Parasitol."},{"key":"2025032409444934200_r2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actatropica.2009.10.023","article-title":"Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches","volume":"115","author":"Urbina","year":"2010","journal-title":"Acta Trop."},{"key":"2025032409444934200_r3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0074-02762009000900022","article-title":"Morbidity and prognostic factors in chronic chagasic cardiopathy","volume":"104","author":"Rocha","year":"2009","journal-title":"Mem. 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Pathol."},{"key":"2025032409444934200_r6","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1086\/503812","article-title":"Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi","volume":"193","author":"Hardison","year":"2006","journal-title":"J. Infect. Dis."},{"key":"2025032409444934200_r7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/427515","article-title":"CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi","volume":"191","author":"Machado","year":"2005","journal-title":"J. Infect. 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