{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:41:27Z","timestamp":1791157287809,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Naive T cells receive stimulation from the positive selecting ligand in the periphery for their survival. This stimulation does not normally lead to overt activation of T cells, as the T cells remain largely quiescent until they receive either antigenic or lymphopenic stimuli. The underlying mechanism responsible for survival and quiescence of the naive T cells remains largely unknown. In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset. The Tsc1-deficient T cells have increased cell proliferation and apoptosis. Tsc1 deletion affects the survival and quiescence of T cells in the absence of antigenic stimulation. Loss of quiescence but not cellularity was inhibited by rapamycin. Our data demonstrate that tuberous sclerosis complex\u2013mammalian target of rapamycin maintains quiescence and survival of T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1003968","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T09:17:07Z","timestamp":1309252627000},"page":"1106-1112","source":"Crossref","is-referenced-by-count":72,"title":["The Tuberous Sclerosis Complex\u2013Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells"],"prefix":"10.1093","volume":"187","author":[{"given":"Qi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Cold Spring Harbor Laboratories, Cold Spring Harbor , NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Cold Spring Harbor Laboratories, Cold Spring Harbor , NY 11724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Ikenoue","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Life Science Institute, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiao","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Department of Microbiology and Immunology, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Liang","family":"Guan","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Life Science Institute, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Department of Pharmacology, University of California at San Diego , La Jolla, CA 92093"},{"name":"Moores Cancer Center, University of California at San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Department of Internal Medicine, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical School , Ann Arbor, MI 48109"},{"name":"Comprehensive Cancer Center , Ann Arbor, MI 48109"},{"name":"Department of Pathology, University of Michigan Medical School , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2025032410252867700_r1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/1074-7613(94)90038-8","article-title":"ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR\u03b6 in murine thymocytes and lymph node T cells","volume":"1","author":"van Oers","year":"1994","journal-title":"Immunity"},{"key":"2025032410252867700_r2","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.1073\/pnas.141218898","article-title":"How \u03b1\u03b2 T cells deal with induced TCR\u03b1 ablation","volume":"98","author":"Polic","year":"2001","journal-title":"Proc. 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