{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:19:56Z","timestamp":1791188396660,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although obstructive jaundice has been associated with a predisposition toward infections, the effects of bile duct ligation (BDL) on bulk intrahepatic T cells have not been clearly defined. The aim of this study was to determine the consequences of BDL on liver T cell phenotype and function. After BDL in mice, we found that bulk liver T cells were less responsive to allogeneic or syngeneic Ag-loaded dendritic cells. Spleen T cell function was not affected, and the viability of liver T cells was preserved. BDL expanded the number of CD4+CD25+Foxp3+ regulatory T cells (Treg), which were anergic to direct CD3 stimulation and mediated T cell suppression in vitro. Adoptively transferred CD4+CD25\u2212 T cells were converted into Treg within the liver after BDL. In vivo depletion of Treg after BDL restored bulk liver T cell function but exacerbated the degrees of inflammatory cytokine production, cholestasis, and hepatic fibrosis. Thus, BDL expands liver Treg, which reduce the function of bulk intrahepatic T cells yet limit liver injury.<\/jats:p>","DOI":"10.4049\/jimmunol.1004077","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T03:13:04Z","timestamp":1308798784000},"page":"1150-1156","source":"Crossref","is-referenced-by-count":69,"title":["Obstructive Jaundice Expands Intrahepatic Regulatory T Cells, Which Impair Liver T Lymphocyte Function but Modulate Liver Cholestasis and Fibrosis"],"prefix":"10.1093","volume":"187","author":[{"given":"Steven C","family":"Katz","sequence":"first","affiliation":[{"name":"Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"},{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"},{"name":"Department of Surgery, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Plitas","sequence":"additional","affiliation":[{"name":"Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umer I","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Peter","family":"Kingham","sequence":"additional","affiliation":[{"name":"Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Naheed","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnandai","family":"Somasundar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"},{"name":"Department of Surgery, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Joseph","family":"Espat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"},{"name":"Department of Surgery, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P","family":"Junghans","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center , Providence, RI 02908"},{"name":"Department of Surgery, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P","family":"DeMatteo","sequence":"additional","affiliation":[{"name":"Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2025032410241168300_r1","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.4049\/jimmunol.176.12.7189","article-title":"Biliary obstruction selectively expands and activates liver myeloid dendritic cells","volume":"176","author":"Bleier","year":"2006","journal-title":"J. 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