{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:10:45Z","timestamp":1791216645733,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The ATP-gated P2X7 receptor (P2X7R) was shown to be an important mediator of inflammation and inflammatory pain through its regulation of IL-1\u03b2 processing and release. Trichinella spiralis-infected mice develop a postinflammatory visceral hypersensitivity that is reminiscent of the clinical features associated with postinfectious irritable bowel syndrome. In this study, we used P2X7R knockout mice (P2X7R\u2212\/\u2212) to investigate the role of P2X7R activation in the in vivo production of IL-1\u03b2 and the development of postinflammatory visceral hypersensitivity in the T. spiralis-infected mouse. During acute nematode infection, IL-1\u03b2\u2013containing cells and P2X7R expression were increased in the jejunum of wild-type (WT) mice. Peritoneal and serum IL-1\u03b2 levels were also increased, which was indicative of elevated IL-1\u03b2 release. However, in the P2X7R\u2212\/\u2212 animals, we found that infection had no effect upon intracellular, plasma, or peritoneal IL-1\u03b2 levels. Conversely, infection augmented peritoneal TNF-\u03b1 levels in both WT and P2X7R\u2212\/\u2212 animals. Infection was also associated with a P2X7R-dependent increase in extracellular peritoneal lactate dehydrogenase, and it triggered immunological changes in both strains. Jejunal afferent fiber mechanosensitivity was assessed in uninfected and postinfected WT and P2X7R\u2212\/\u2212 animals. Postinfected WT animals developed an augmented afferent fiber response to mechanical stimuli; however, this did not develop in postinfected P2X7R\u2212\/\u2212 animals. Therefore, our results demonstrated that P2X7Rs play a pivotal role in intestinal inflammation and are a trigger for the development of visceral hypersensitivity.<\/jats:p>","DOI":"10.4049\/jimmunol.1100423","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T03:13:04Z","timestamp":1308798784000},"page":"1467-1474","source":"Crossref","is-referenced-by-count":55,"title":["P2X7 Receptor-Dependent Intestinal Afferent Hypersensitivity in a Mouse Model of Postinfectious Irritable Bowel Syndrome"],"prefix":"10.1093","volume":"187","author":[{"given":"Christopher","family":"Keating","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Sheffield , Sheffield S10 2TN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Pelegrin","sequence":"additional","affiliation":[{"name":"Unidad de Inflamaci\u00f3n y Cirug\u00eda Experimental, Hospital Universitario Virgen de la Arrixaca, Fundaci\u00f3n Formaci\u00f3n Investigaci\u00f3n Sanitaria Regi\u00f3n de Murcia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas , 30120 Murcia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Inflamaci\u00f3n y Cirug\u00eda Experimental, Hospital Universitario Virgen de la Arrixaca, Fundaci\u00f3n Formaci\u00f3n Investigaci\u00f3n Sanitaria Regi\u00f3n de Murcia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas , 30120 Murcia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grundy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sheffield , Sheffield S10 2TN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"2025032410242302900_r1","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/j.1572-0241.2003.07542.x","article-title":"Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome","volume":"98","author":"Dunlop","year":"2003","journal-title":"Am. 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