{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:25:31Z","timestamp":1770881131026,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cerebral malaria is the most severe complication of Plasmodium falciparum infection and accounts for a large number of malaria fatalities worldwide. Recent studies demonstrated that C5\u2212\/\u2212 mice are resistant to experimental cerebral malaria (ECM) and suggested that protection was due to loss of C5a-induced inflammation. Surprisingly, we observed that C5aR\u2212\/\u2212 mice were fully susceptible to disease, indicating that C5a is not required for ECM. C3aR\u2212\/\u2212 and C3aR\u2212\/\u2212 \u00d7 C5aR\u2212\/\u2212 mice were equally susceptible to ECM as were wild-type mice, indicating that neither complement anaphylatoxin receptor is critical for ECM development. In contrast, C9 deposition in the brains of mice with ECM suggested an important role for the terminal complement pathway. Treatment with anti-C9 Ab significantly increased survival time and reduced mortality in ECM. Our data indicate that protection from ECM in C5\u2212\/\u2212 mice is mediated through inhibition of membrane attack complex formation and not through C5a-induced inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.1100603","type":"journal-article","created":{"date-parts":[[2011,5,14]],"date-time":"2011-05-14T03:16:31Z","timestamp":1305342991000},"page":"6657-6660","source":"Crossref","is-referenced-by-count":23,"title":["Cutting Edge: The Membrane Attack Complex of Complement Is Required for the Development of Murine Experimental Cerebral Malaria"],"prefix":"10.1093","volume":"186","author":[{"given":"Theresa N","family":"Ramos","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Department of Neurology, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan M","family":"Darley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Department of Neurology, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Department of Neurology, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Billker","sequence":"additional","affiliation":[{"name":"Malaria Programme, Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SA ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian C","family":"Rayner","sequence":"additional","affiliation":[{"name":"Malaria Programme, Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SA ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Ahras","sequence":"additional","affiliation":[{"name":"Malaria Programme, Wellcome Trust Sanger Institute , Hinxton, Cambridge CB10 1SA ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian E","family":"Wohler","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Department of Neurology, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R","family":"Barnum","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham , Birmingham, AL 35294"},{"name":"Department of Neurology, University of Alabama at Birmingham , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"2025032411334031900_r1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pt.2006.06.006","article-title":"Mapping the global extent of malaria in 2005","volume":"22","author":"Guerra","year":"2006","journal-title":"Trends Parasitol."},{"key":"2025032411334031900_r2","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.4049\/jimmunol.0804153","article-title":"World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not","volume":"182","author":"Pierce","year":"2009","journal-title":"J. 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