{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:17:23Z","timestamp":1780060643462,"version":"3.54.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alopecia areata is among the most prevalent autoimmune diseases, yet compared with other autoimmune conditions, it is not well studied. This in part results from limitations in the C3H\/HeJ mouse and DEBR rat model systems most commonly used to study the disease, which display a low frequency and late onset. We describe a novel high-incidence model for spontaneous alopecia areata. The 1MOG244 T cell expresses dual TCRA chains, one of which, when combined with the single TCRB present, promotes the development of CD8+ T cells with specificity for hair follicles. Retroviral transgenic mice expressing this TCR develop spontaneous alopecia areata at nearly 100% incidence. Disease initially follows a reticular pattern, with regionally cyclic episodes of hair loss and regrowth, and ultimately progresses to alopecia universalis. Alopecia development is associated with CD8+ T cell activation, migration into the intrafollicular region, and hair follicle destruction. The disease may be adoptively transferred with T lymphocytes and is class I and not class II MHC-dependent. Pathologic T cells primarily express IFNG and IL-17 early in disease, with dramatic increases in cytokine production and recruitment of IL-4 and IL-10 production with disease progression. Inhibition of individual cytokines did not significantly alter disease incidence, potentially indicating redundancy in cytokine responses. These results therefore characterize a new high-incidence model for alopecia areata in C57BL\/6J mice, the first to our knowledge to apply a monoclonal TCR, and indicate that class I MHC-restricted CD8+ T lymphocytes can independently mediate the pathologic response.<\/jats:p>","DOI":"10.4049\/jimmunol.1100657","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T02:10:45Z","timestamp":1322100645000},"page":"477-486","source":"Crossref","is-referenced-by-count":57,"title":["A Mouse Model of Clonal CD8+ T Lymphocyte-Mediated Alopecia Areata Progressing to Alopecia Universalis"],"prefix":"10.1093","volume":"188","author":[{"given":"Rajshekhar","family":"Alli","sequence":"first","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Department of Pathology, Vanderbilt University , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Sundberg","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence L","family":"Geiger","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2025032409431424100_r1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.autrev.2005.07.001","article-title":"Alopecia areata: a tissue specific autoimmune disease of the hair follicle","volume":"5","author":"Gilhar","year":"2006","journal-title":"Autoimmun. 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