{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:20:31Z","timestamp":1791328831435,"version":"4.3.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T cells mediate rapid tissue responses in murine skin and participate in cutaneous immune regulation including protection against cancer. The role of human \u03b3\u03b4 cells in cutaneous homeostasis and pathology is characterized poorly. In this study, we show in vivo evidence that human blood contains a distinct subset of proinflammatory cutaneous lymphocyte Ag and CCR6-positive V\u03b39V\u03b42 T cells, which is rapidly recruited into perturbed human skin. V\u03b39V\u03b42 T cells produced an array of proinflammatory mediators including IL-17A and activated keratinocytes in a TNF-\u03b1\u2013 and IFN-\u03b3\u2013dependent manner. Examination of the common inflammatory skin disease psoriasis revealed a striking reduction of circulating V\u03b39V\u03b42 T cells in psoriasis patients compared with healthy controls and atopic dermatitis patients. Decreased numbers of circulating V\u03b39V\u03b42 T cells normalized after successful treatment with psoriasis-targeted therapy. Taken together with the increased presence of V\u03b39V\u03b42 T cells in psoriatic skin, these data indicate redistribution of V\u03b39V\u03b42 T cells from the blood to the skin compartment in psoriasis. In summary, we report a novel human proinflammatory \u03b3\u03b4 T cell involved in skin immune surveillance with immediate response characteristics and with potential clinical relevance in inflammatory skin disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1100804","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T07:02:30Z","timestamp":1312441350000},"page":"2783-2793","source":"Crossref","is-referenced-by-count":310,"title":["Identification of a Novel Proinflammatory Human Skin-Homing V\u03b39V\u03b42 T Cell Subset with a Potential Role in Psoriasis"],"prefix":"10.1093","volume":"187","author":[{"given":"Ute","family":"Laggner","sequence":"first","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Di Meglio","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri K","family":"Perera","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hundhausen","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie E","family":"Lacy","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niwa","family":"Ali","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H","family":"Smith","sequence":"additional","affiliation":[{"name":"Skin Therapy Research Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C","family":"Hayday","sequence":"additional","affiliation":[{"name":"Department of Immunology, King\u2019s College London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Nickoloff","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Michigan State University College of Human Medicine , Grand Rapids, MI 49503"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank O","family":"Nestle","sequence":"additional","affiliation":[{"name":"Cutaneous Medicine and Immunotherapy Unit, St. John\u2019s Institute of Dermatology, King\u2019s College London , London SE1 9RT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"2025032410321883600_r1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.18.1.975","article-title":"\u03b3\u03b4 Cells: a right time and a right place for a conserved third way of protection","volume":"18","author":"Hayday","year":"2000","journal-title":"Annu. 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