{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:50:53Z","timestamp":1790250653520,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The molecular mechanisms that regulate mature T cell fate and enable cells to differentiate into memory T cells are largely unknown. Memory T cells share certain key features with stem cells: they both have the ability to self-renew and are long-lived. The Wnt\u2013\u03b2-catenin signaling pathway is a key player in regulating stem cell self-renewal and differentiation. We generated a conditional knockout mouse that specifically lacks \u03b2-catenin in mature T cells and report in this article that \u03b2-catenin is not involved in regulating effector versus memory T cell differentiation. \u03b2-catenin\u2013deficient memory T cells were phenotypically and functionally indistinguishable from control cells and made normal recall responses. \u03b2-catenin deficiency does not affect T cell migration, T cell function in a model of chronic infection, or lymphopenia-induced proliferation. Together, our data suggest that self-renewal and differentiation are regulated differently in memory T cells compared with epithelial and hematopoietic stem cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1100907","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T07:20:58Z","timestamp":1309764058000},"page":"1542-1546","source":"Crossref","is-referenced-by-count":44,"title":["Cutting Edge: \u03b2-Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses"],"prefix":"10.1093","volume":"187","author":[{"given":"Martin","family":"Prlic","sequence":"first","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Bevan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,15]]},"reference":[{"key":"2025032410282981800_r1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. 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