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To investigate the potential role of class Ib molecules in anti-viral immune responses, Kb\u2212\/\u2212Db\u2212\/\u2212CIITA\u2212\/\u2212 mice lacking expression of MHC class Ia and class II molecules were infected with lymphocytic choriomeningitis virus (LCMV). These animals have a large class Ib-selected CD8+ T cell population and they were observed to mediate partial (but incomplete) virus clearance during acute LCMV infection as compared with Kb\u2212\/\u2212Db\u2212\/\u2212\u03b22-microglobulin\u2212\/\u2212 mice that lack expression of both MHC class Ia and class Ib molecules. Infection was associated with expansion of splenic CD8+ T cells and induction of granzyme B and IFN-\u03b3 effector molecules in CD8+ T cells. Partial virus clearance was dependent on CD8+ cells. In vitro T cell restimulation assays demonstrated induction of a population of \u03b22-microglobulin\u2013dependent, MHC class Ib-restricted CD8+ T cells with specificity for viral Ags and yet to be defined nonclassical MHC molecules. MHC class Ib-restricted CD8+ T cell responses were also observed after infection of Kb\u2212\/\u2212Db\u2212\/\u2212mice despite the low number of CD8+ T cells in these animals. Long-term infection studies demonstrated chronic infection and gradual depletion of CD8+ T cells in Kb\u2212\/\u2212Db\u2212\/\u2212CIITA\u2212\/\u2212 mice, demonstrating that class Ia molecules are required for viral clearance. These findings demonstrate that class Ib-restricted CD8+ T cells have the potential to participate in the host immune response to LCMV.<\/jats:p>","DOI":"10.4049\/jimmunol.1101171","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T20:02:15Z","timestamp":1321387335000},"page":"6463-6472","source":"Crossref","is-referenced-by-count":7,"title":["An MHC Class Ib-Restricted CD8+ T Cell Response to Lymphocytic Choriomeningitis Virus"],"prefix":"10.1093","volume":"187","author":[{"given":"Lili","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C","family":"Jay","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared D","family":"Fairbanks","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, UT 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"2025032410521708900_r1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.immunol.21.090501.080116","article-title":"Genomic organization of the mammalian MHC","volume":"21","author":"Kum\u00e1novics","year":"2003","journal-title":"Annu. 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Med."},{"key":"2025032410521708900_r33","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.178.6.3806","article-title":"H2-M3-restricted CD8+ T cells induced by peptide-pulsed dendritic cells confer protection against Mycobacterium tuberculosis","volume":"178","author":"Doi","year":"2007","journal-title":"J. Immunol."},{"key":"2025032410521708900_r34","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1128\/IAI.73.12.8002-8008.2005","article-title":"H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium","volume":"73","author":"Ugrinovic","year":"2005","journal-title":"Infect. 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Immunol."},{"key":"2025032410521708900_r38","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1128\/jvi.68.12.8056-8063.1994","article-title":"CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection","volume":"68","author":"Matloubian","year":"1994","journal-title":"J. Virol."},{"key":"2025032410521708900_r39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"2025032410521708900_r40","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1243::AID-IMMU1243>3.0.CO;2-A","article-title":"Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses","volume":"29","author":"P\u00e9rarnau","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2025032410521708900_r41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"Ahmed","year":"1984","journal-title":"J. Exp. Med."},{"key":"2025032410521708900_r42","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.4049\/jimmunol.165.11.6381","article-title":"V\u03b2 T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules","volume":"165","author":"Laouini","year":"2000","journal-title":"J. Immunol."},{"key":"2025032410521708900_r43","doi-asserted-by":"crossref","first-page":"10746","DOI":"10.1128\/JVI.75.22.10746-10754.2001","article-title":"Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus","volume":"75","author":"Hobbs","year":"2001","journal-title":"J. Virol."},{"key":"2025032410521708900_r44","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/eji.200425495","article-title":"Long-term loss of canonical NKT cells following an acute virus infection","volume":"35","author":"Lin","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"2025032410521708900_r45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.coi.2004.02.005","article-title":"The role of programming in memory T-cell development","volume":"16","author":"Masopust","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"2025032410521708900_r46","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/eji.200939555","article-title":"Pathways of memory CD8+ T-cell development","volume":"39","author":"Bannard","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025032410521708900_r47","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.174.10.5936","article-title":"Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections","volume":"174","author":"Liu","year":"2005","journal-title":"J. Immunol."},{"key":"2025032410521708900_r48","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1073\/pnas.092675799","article-title":"IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells","volume":"99","author":"Liu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. 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Immunol."},{"key":"2025032410521708900_r52","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.immuni.2011.03.020","article-title":"Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection","volume":"34","author":"Nolz","year":"2011","journal-title":"Immunity"},{"key":"2025032410521708900_r53","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025032410521708900_r54","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. 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Immunol."},{"key":"2025032410521708900_r58","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.4049\/jimmunol.163.6.3022","article-title":"Peptide affinity and concentration affect the sensitivity of M3-restricted CTLs induced in vitro","volume":"163","author":"Byers","year":"1999","journal-title":"J. Immunol."},{"key":"2025032410521708900_r59","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.4049\/jimmunol.169.10.5708","article-title":"Peptide-independent folding and CD8\u03b1\u03b1 binding by the nonclassical class I molecule, thymic leukemia antigen","volume":"169","author":"Weber","year":"2002","journal-title":"J. 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