{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:56:32Z","timestamp":1791212192027,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) and periodontal disease (PD) are prevalent chronic inflammatory disorders that affect bone structures. Individuals with RA are more likely to experience PD, but how disease in joints could induce PD remains unknown. This study aimed to experimentally mimic clinical parameters of RA-induced PD and to provide mechanistic findings to explain this association. Chronic Ag-induced arthritis (AIA) was triggered by injection of methylated BSA in the knee joint of immunized mice. Anti\u2013TNF-\u03b1 was used to assess the role of this cytokine. Intra-articular challenge induced infiltration of cells, synovial hyperplasia, bone resorption, proteoglycan loss, and increased expression of cytokines exclusively in challenged joints. Simultaneously, AIA resulted in severe alveolar bone loss, migration of osteoclasts, and release of proinflammatory cytokines in maxillae. Anti\u2013TNF-\u03b1 therapy prevented the development of both AIA and PD. AIA did not modify bacterial counts in the oral cavity. PD, but not AIA, induced by injection of Ag in immunized mice was decreased by local treatment with antiseptic, which decreased the oral microbiota. AIA was associated with an increase in serum C-reactive protein levels and the expression of the transcription factors ROR\u03b3 and Foxp3 in cervical lymph nodes. There were higher titers of anti-collagen I IgG, and splenocytes were more responsive to collagen I in AIA mice. In conclusion, AIA-induced PD was dependent on TNF-\u03b1 and the oral microbiota. Moreover, PD was associated with changes in expression of lymphocyte transcription factors, presence of anti-collagen Abs, and increased reactivity to autoantigens.<\/jats:p>","DOI":"10.4049\/jimmunol.1101195","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T20:26:38Z","timestamp":1314995198000},"page":"3821-3830","source":"Crossref","is-referenced-by-count":90,"title":["Experimental Arthritis Triggers Periodontal Disease in Mice: Involvement of TNF-\u03b1 and the Oral Microbiota"],"prefix":"10.1093","volume":"187","author":[{"given":"Celso Martins","family":"Queiroz-Junior","sequence":"first","affiliation":[{"name":"Departamento de Cl\u00ednica, Patologia e Cirurgia Odontol\u00f3gicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]},{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]},{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila Fernandes Moreira","family":"Madeira","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]},{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Matos","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Vasconcelos","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Leal Costa","family":"Bessoni","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica, Patologia e Cirurgia Odontol\u00f3gicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]},{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Fonseca da Cunha","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Pompermaier","family":"Garlet","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Odontologia de Bauru, Universidade de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil, CEP 17.012-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle da Gl\u00f3ria","family":"de Souza","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edlia Aparecida","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica, Patologia e Cirurgia Odontol\u00f3gicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]},{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Minas Gerais ,","place":["Brazil, CEP 31.270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"2025032410385006000_r1","first-page":"33","article-title":"State of periodontium in patients affected with rheumatism","volume":"43","author":"Liubomorova","year":"1964","journal-title":"Stomatologiia"},{"key":"2025032410385006000_r2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1902\/jop.2008.070501","article-title":"Association among rheumatoid arthritis, oral hygiene, and periodontitis","volume":"79","author":"Pischon","year":"2008","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","article-title":"Periodontitis in systemic rheumatic diseases","volume":"5","author":"de Pablo","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"2025032410385006000_r4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/gene.2010.13","article-title":"Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences","volume":"11","author":"Trombone","year":"2010","journal-title":"Genes Immun."},{"key":"2025032410385006000_r5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1600-051X.2010.01645.x","article-title":"Mechanism of alveolar bone loss in a collagen-induced arthritis model in mice","volume":"38","author":"Park","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"2025032410385006000_r6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-051X.1990.tb01091.x","article-title":"Serum antibodies and loss of periodontal bone in patients with rheumatoid arthritis","volume":"17","author":"Tolo","year":"1990","journal-title":"J. Clin. Periodontol."},{"key":"2025032410385006000_r7","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/art.1780401221","article-title":"Risk for periodontal disease in patients with longstanding rheumatoid arthritis","volume":"40","author":"K\u00e4sser","year":"1997","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1034\/j.1600-051x.2000.027004267.x","article-title":"Is there a relationship between rheumatoid arthritis and periodontal disease?","volume":"27","author":"Mercado","year":"2000","journal-title":"J. Clin. Periodontol."},{"key":"2025032410385006000_r9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1902\/jop.2001.72.6.779","article-title":"Relationship between rheumatoid arthritis and periodontitis","volume":"72","author":"Mercado","year":"2001","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1902\/jop.2006.050051","article-title":"Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis","volume":"77","author":"Havemose-Poulsen","year":"2006","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/S1806-83242008000100013","article-title":"Periodontal condition in patients with rheumatoid arthritis","volume":"22","author":"Ishi Ede","year":"2008","journal-title":"Braz. Oral Res."},{"key":"2025032410385006000_r12","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1902\/jop.2007.060520","article-title":"Decreased interleukin-1\u03b2 and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis","volume":"78","author":"Miranda","year":"2007","journal-title":"J. Periodontol."},{"issue":"11","key":"2025032410385006000_r13","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1902\/jop.2005.76.11-S.2066","article-title":"Periodontitis and rheumatoid arthritis: a review","volume":"76","author":"Bartold","year":"2005","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/154405910608500201","article-title":"Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical \u201ctwo-hit\u201d model","volume":"85","author":"Golub","year":"2006","journal-title":"J. Dent. Res."},{"key":"2025032410385006000_r15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cyto.2006.07.020","article-title":"Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report","volume":"35","author":"Bozkurt","year":"2006","journal-title":"Cytokine"},{"key":"2025032410385006000_r16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1902\/jop.2005.76.2.229","article-title":"Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases","volume":"76","author":"Ramamurthy","year":"2005","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r17","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1002\/art.22939","article-title":"CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis","volume":"56","author":"Wengner","year":"2007","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2249.2006.03260.x","article-title":"The dual role of p55 tumour necrosis factor-\u03b1 receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction","volume":"147","author":"Garlet","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"2025032410385006000_r19","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/ar1872","article-title":"Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis","volume":"8","author":"Zwerina","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"2025032410385006000_r20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1476-5381.2010.00895.x","article-title":"Cooperative role of tumour necrosis factor-\u03b1, interleukin-1\u03b2 and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice","volume":"162","author":"Sachs","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"2025032410385006000_r21","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/art.22732","article-title":"Interferon-\u03b3 protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints","volume":"56","author":"Williams","year":"2007","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/ard.2008.105775","article-title":"Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNFalpha single-chain Fv antibody (ESBA105) designed for local therapeutic use","volume":"69","author":"Urech","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"2025032410385006000_r23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1189\/jlb.1104682","article-title":"Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1","volume":"78","author":"Barcelos","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2025032410385006000_r24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.imlet.2009.12.005","article-title":"Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells","volume":"130","author":"Van de Velde","year":"2010","journal-title":"Immunol. Lett."},{"key":"2025032410385006000_r25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/ar71","article-title":"Interferon-\u03b3 production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8","volume":"2","author":"Berg","year":"2000","journal-title":"Arthritis Res."},{"key":"2025032410385006000_r26","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1902\/jop.2000.71.9.1395","article-title":"HLA-B27 transgenic rats are susceptible to accelerated alveolar bone loss","volume":"71","author":"Tatakis","year":"2000","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2025032410385006000_r28","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1902\/jop.2009.090015","article-title":"Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis","volume":"80","author":"Mayer","year":"2009","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r29","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1902\/jop.2008.070616","article-title":"Anti-TNF-\u03b1 immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis","volume":"79","author":"Pers","year":"2008","journal-title":"J. Periodontol."},{"key":"2025032410385006000_r30","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"2025032410385006000_r31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/10454411970080020801","article-title":"Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature","volume":"8","author":"Havemose-Poulsen","year":"1997","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"2025032410385006000_r32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1172\/JCI0213462","article-title":"Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis","volume":"109","author":"Adkison","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025032410385006000_r33","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/art.21892","article-title":"Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis","volume":"54","author":"Mullazehi","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/art.23049","article-title":"Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation","volume":"58","author":"Nandakumar","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.0818-9641.2004.01267.x","article-title":"An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes","volume":"82","author":"Amirahmadi","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"2025032410385006000_r36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2003.11.010","article-title":"Measurement of antibodies to collagen II by inhibition of collagen fibril formation in vitro","volume":"285","author":"Gray","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"2025032410385006000_r37","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/art.21097","article-title":"Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells","volume":"52","author":"Amirahmadi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"2025032410385006000_r39","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1600-051X.2010.01586.x","article-title":"Regulatory T cells attenuate experimental periodontitis progression in mice","volume":"37","author":"Garlet","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"2025032410385006000_r40","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.21749","article-title":"Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort)","volume":"54","author":"Kirkham","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2025032410385006000_r41","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025032410385006000_r42","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.4049\/jimmunol.176.10.6262","article-title":"Interleukin-17 acts independently of TNF-\u03b1 under arthritic conditions","volume":"176","author":"Koenders","year":"2006","journal-title":"J. Immunol."},{"key":"2025032410385006000_r43","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/0022034510376402","article-title":"Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints","volume":"89","author":"Garlet","year":"2010","journal-title":"J. Dent. Res."},{"key":"2025032410385006000_r44","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4049\/jimmunol.179.3.1449","article-title":"TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses","volume":"179","author":"Iwamoto","year":"2007","journal-title":"J. Immunol."},{"key":"2025032410385006000_r45","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1073\/pnas.0408506102","article-title":"Cross-regulation of TNF and IFN-alpha in autoimmune diseases","volume":"102","author":"Palucka","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/7\/3821\/61584469\/1101195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/187\/7\/3821\/61584469\/1101195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:37:45Z","timestamp":1743122265000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/187\/7\/3821\/7976552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,1]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1101195","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13296986.14726175","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13296986.14657098","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,10]]},"published":{"date-parts":[[2011,10,1]]}}}