{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:52:06Z","timestamp":1790254326974,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Resolvins of the D series are generated from docosahexaenoic acid, which are enriched in fish oils and are believed to exert beneficial roles on diverse inflammatory disorders, including inflammatory bowel disease (IBD). In this study, we investigated the anti-inflammatory effects of the aspirin-triggered resolvin D1 (AT-RvD1), its precursor (17(R)-hydroxy docosahexaenoic acid [17R-HDHA]) and resolvin D2 (RvD2) in dextran sulfate sodium (DSS)- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Our results showed that the systemic treatment with AT-RvD1, RvD2, or 17R-HDHA in a nanogram range greatly improved disease activity index, body weight loss, colonic damage, and polymorphonuclear infiltration in both colitis experimental models. Moreover, these treatments reduced colonic cytokine levels for TNF-\u03b1, IL-1\u03b2, MIP-2, and CXCL1\/KC, as well as mRNA expression of NF-\u03baB and the adhesion molecules VCAM-1, ICAM-1, and LFA-1. Furthermore, AT-RvD1, but not RvD2 or 17R-HDHA, depended on lipoxin A4 receptor (ALX) activation to inhibit IL-6, MCP-1, IFN-\u03b3, and TNF-\u03b1 levels in bone marrow-derived macrophages stimulated with LPS. Similarly, ALX blockade reversed the beneficial effects of AT-RvD1 in DSS-induced colitis. To our knowledge, our findings showed for the first time the anti-inflammatory effects of resolvins of the D series and precursor 17R-HDHA in preventing experimental colitis. We also demonstrated the relevant role exerted by ALX activation on proresolving action of AT-RvD1. Moreover, AT-RvD1 showed a higher potency than 17R-HDHA and RvD2 in preventing DSS-induced colitis. The results suggest that these lipid mediators possess a greater efficacy when compared with other currently used IBD therapies, such as monoclonal anti-TNF, and have the potential to be used for treating IBD.<\/jats:p>","DOI":"10.4049\/jimmunol.1101305","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T07:20:58Z","timestamp":1309764058000},"page":"1957-1969","source":"Crossref","is-referenced-by-count":240,"title":["Omega-3 Fatty Acid-Derived Mediators 17(\n                    <i>R<\/i>\n                    )-Hydroxy Docosahexaenoic Acid, Aspirin-Triggered Resolvin D1 and Resolvin D2 Prevent Experimental Colitis in Mice"],"prefix":"10.1093","volume":"187","author":[{"given":"Allisson Freire","family":"Bento","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88049-900, Florian\u00f3polis, Santa Catarina 88049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Franco","family":"Claudino","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88049-900, Florian\u00f3polis, Santa Catarina 88049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Cypriano","family":"Dutra","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88049-900, Florian\u00f3polis, Santa Catarina 88049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Marcon","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88049-900, Florian\u00f3polis, Santa Catarina 88049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B","family":"Calixto","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88049-900, Florian\u00f3polis, Santa Catarina 88049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,15]]},"reference":[{"key":"2025032410284422400_r1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCRESAHA.110.223883","article-title":"Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins","volume":"107","author":"Spite","year":"2010","journal-title":"Circ. 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Biol."},{"key":"2025032410284422400_r36","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1476-5381.2009.00271.x","article-title":"Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, \u03b1- and \u03b2-amyrin, in a mouse model of colitis","volume":"157","author":"Vitor","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"2025032410284422400_r37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.4049\/jimmunol.146.4.1192","article-title":"Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-\u03b3","volume":"146","author":"Barker","year":"1991","journal-title":"J. Immunol."},{"key":"2025032410284422400_r38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1749-6632.1997.tb52031.x","article-title":"Novel roles for E-selectin in endothelial-leukocyte adhesion","volume":"811","author":"Yoshida","year":"1997","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2025032410284422400_r39","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1073\/pnas.0907342107","article-title":"Resolvin D1 binds human phagocytes with evidence for proresolving receptors","volume":"107","author":"Krishnamoorthy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410284422400_r40","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.4049\/jimmunol.168.10.5260","article-title":"Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis","volume":"168","author":"Gewirtz","year":"2002","journal-title":"J. Immunol."},{"key":"2025032410284422400_r41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0016-5085(90)90290-H","article-title":"A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice","volume":"98","author":"Okayasu","year":"1990","journal-title":"Gastroenterology"},{"key":"2025032410284422400_r42","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1172\/JCI114799","article-title":"Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis","volume":"86","author":"Cominelli","year":"1990","journal-title":"J. Clin. Invest."},{"key":"2025032410284422400_r43","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/eji.1830270722","article-title":"Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice","volume":"27","author":"Neurath","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"2025032410284422400_r44","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2004.02.070","article-title":"Optimizing anti-TNF treatment in inflammatory bowel disease","volume":"126","author":"Rutgeerts","year":"2004","journal-title":"Gastroenterology"},{"key":"2025032410284422400_r45","first-page":"1632","article-title":"Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure","volume":"21","author":"Essani","year":"1995","journal-title":"Hepatology"},{"key":"2025032410284422400_r46","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.4049\/jimmunol.164.6.3309","article-title":"TNF-\u03b1, IL-4, and IFN-\u03b3 regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells","volume":"164","author":"Stocker","year":"2000","journal-title":"J. Immunol."},{"key":"2025032410284422400_r47","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.dld.2005.03.013","article-title":"Adhesion molecules in inflammatory bowel disease: therapeutic implications for gut inflammation","volume":"37","author":"Danese","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"2025032410284422400_r48","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0016-5085(99)70070-3","article-title":"VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis","volume":"116","author":"Sans","year":"1999","journal-title":"Gastroenterology"},{"key":"2025032410284422400_r49","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/labinvest.3780164","article-title":"VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice","volume":"80","author":"Soriano","year":"2000","journal-title":"Lab. 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Sci."},{"key":"2025032410284422400_r51","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/00007890-199612150-00020","article-title":"Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion","volume":"62","author":"Khalfoun","year":"1996","journal-title":"Transplantation"},{"key":"2025032410284422400_r52","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jcp.21188","article-title":"Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid","volume":"214","author":"Rahman","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"2025032410284422400_r53","doi-asserted-by":"crossref","DOI":"10.1111\/j.1476-5381.2011.01345.x","article-title":"The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats","author":"Lima-Garcia","year":"2011","journal-title":"Br. J. 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Pharmacol."},{"key":"2025032410284422400_r57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.bjp.0704768","article-title":"Docosahexaenoic acid potentiates interleukin-1\u03b2 induction of nitric oxide synthase through mechanism involving p44\/42 MAPK activation in rat vascular smooth muscle cells","volume":"136","author":"Hirafuji","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"2025032410284422400_r58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0169-328X(00)00253-9","article-title":"Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury","volume":"85","author":"Satake","year":"2000","journal-title":"Brain Res. Mol. 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