{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:14Z","timestamp":1791308834590,"version":"4.3.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Con A-induced fulminant hepatitis is a well-known animal model for acute liver failure. However, the role of \u03b3\u03b4 T cells in this model is undefined. In this report, using TCR \u03b4\u2212\/\u2212 mice, we demonstrated a protective role of \u03b3\u03b4 T cells in Con A-induced hepatitis model. TCR \u03b4\u2212\/\u2212 mice showed significantly decreased levels of IL-17A and IL-17F in the Con A-treated liver tissue, and reconstitution of TCR \u03b4\u2212\/\u2212 mice with wild-type (Wt), but not IL-17A\u2212\/\u2212, \u03b3\u03b4 T cells significantly reduced hepatitis, strongly suggesting a critical role of IL-17A in mediating the protective effect of \u03b3\u03b4 T cells. Interestingly, only V\u03b34, but not V\u03b31, \u03b3\u03b4 T cells exerted such a protective effect. Furthermore, depletion of NKT cells in TCR \u03b4\u2212\/\u2212 mice completely abolished hepatitis, and NKT cells from Con A-challenged liver tissues of TCR \u03b4\u2212\/\u2212 mice expressed significantly higher amounts of proinflammatory cytokine IFN-\u03b3 than those from Wt mice, indicating that \u03b3\u03b4 T cells protected hepatitis through targeting NKT cells. Finally, abnormal capacity of IFN-\u03b3 production by NKT cells of TCR \u03b4\u2212\/\u2212 mice could only be downregulated by transferring Wt, but not IL-17\u2212\/\u2212, V\u03b34 \u03b3\u03b4 T cells, confirming an essential role of V\u03b34-derived IL-17A in regulating the function of NKT cells. In summary, our report thus demonstrated a novel function of V\u03b34 \u03b3\u03b4 T cells in mediating a protective effect against Con A-induced fulminant hepatitis through negatively regulating function of NKT cells in an IL-17A\u2013dependent manner, and transferring V\u03b34 \u03b3\u03b4 T cells may provide a novel therapeutic approach for this devastating liver disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1101315","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T05:31:23Z","timestamp":1318311083000},"page":"5007-5014","source":"Crossref","is-referenced-by-count":60,"title":["V\u03b34 \u03b3\u03b4 T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis"],"prefix":"10.1093","volume":"187","author":[{"given":"Na","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]},{"name":"Department of Immunology, Tianjin Medical University , Tianjin, 300070 ,","place":["China"]},{"name":"Department of General Surgery, Tianjin Medical University General Hospital , Tianjin, 300052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlei","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapu","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, 300071 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