{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:39Z","timestamp":1791908379409,"version":"4.3.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mechanisms responsible for nerve injury in leprosy need further elucidation. We recently demonstrated that the foamy phenotype of Mycobacterium leprae-infected Schwann cells (SCs) observed in nerves of multibacillary patients results from the capacity of M. leprae to induce and recruit lipid droplets (LDs; also known as lipid bodies) to bacterial-containing phagosomes. In this study, we analyzed the parameters that govern LD biogenesis by M. leprae in SCs and how this contributes to the innate immune response elicited by M. leprae. Our observations indicated that LD formation requires the uptake of live bacteria and depends on host cell cytoskeleton rearrangement and vesicular trafficking. TLR6 deletion, but not TLR2, completely abolished the induction of LDs by M. leprae, as well as inhibited the bacterial uptake in SCs. M. leprae-induced LD biogenesis correlated with increased PGE2 and IL-10 secretion, as well as reduced IL-12 and NO production in M. leprae-infected SCs. Analysis of nerves from lepromatous leprosy patients showed colocalization of M. leprae, LDs, and cyclooxygenase-2 in SCs, indicating that LDs are sites for PGE2 synthesis in vivo. LD biogenesis Inhibition by the fatty acid synthase inhibitor C-75 abolished the effect of M. leprae on SC production of immunoinflammatory mediators and enhanced the mycobacterial-killing ability of SCs. Altogether, our data indicated a critical role for TLR6-dependent signaling in M. leprae\u2013SC interactions, favoring phagocytosis and subsequent signaling for induction of LD biogenesis in infected cells. Moreover, our observations reinforced the role of LDs favoring mycobacterial survival and persistence in the nerve. These findings give further support to a critical role for LDs in M. leprae pathogenesis in the nerve.<\/jats:p>","DOI":"10.4049\/jimmunol.1101344","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T11:02:30Z","timestamp":1312455750000},"page":"2548-2558","source":"Crossref","is-referenced-by-count":105,"title":["TLR6-Driven Lipid Droplets in <i>Mycobacterium leprae-<\/i>Infected Schwann Cells: Immunoinflammatory Platforms Associated with Bacterial Persistence"],"prefix":"10.1093","volume":"187","author":[{"given":"Katherine A","family":"Mattos","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane G C","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloisa","family":"D\u2019Avila","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana S","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta O","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euzenir N","family":"Sarno","sequence":"additional","affiliation":[{"name":"Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina V","family":"Pessolani","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia T","family":"Bozza","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, RJ 21045-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"2025032410324705200_r1","volume-title":"Leprosy Today","author":"World Health Organization","year":"2010"},{"key":"2025032410324705200_r2","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/1523-1747.ep12381958","article-title":"Th1-Th2 paradigm: insights from leprosy","volume":"102","author":"Modlin","year":"1994","journal-title":"J. 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Biol."},{"key":"2025032410324705200_r10","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bbalip.2009.01.005","article-title":"Leukocyte lipid bodies - Biogenesis and functions in inflammation","volume":"1791","author":"Bozza","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2025032410324705200_r11","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.4049\/jimmunol.0900365","article-title":"Mycobacterium bovis bacillus Calmette-Gu\u00e9rin infection induces TLR2-dependent peroxisome proliferator-activated receptor gamma expression and activation: functions in inflammation, lipid metabolism, and pathogenesis","volume":"183","author":"Almeida","year":"2009","journal-title":"J. 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Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides","volume":"141","author":"Renz","year":"1988","journal-title":"J. Immunol."},{"key":"2025032410324705200_r15","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.intimp.2008.01.035","article-title":"Lipid bodies in innate immune response to bacterial and parasite infections","volume":"8","author":"D\u2019Avila","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"2025032410324705200_r16","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1086\/513788","article-title":"The role of cytokines in Schwann cell damage, protection, and repair","volume":"176","author":"Lisak","year":"1997","journal-title":"J. Infect. Dis."},{"key":"2025032410324705200_r17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-5728(99)00132-0","article-title":"Signals for proinflammatory cytokine secretion by human Schwann cells","volume":"101","author":"Rutkowski","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"2025032410324705200_r18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1529-8027.2007.00139.x","article-title":"Expression of metalloproteinases (MMP-2, MMP-9, and TACE) and TNF-alpha in the nerves of leprosy patients","volume":"12","author":"Teles","year":"2007","journal-title":"J. Peripher. Nerv. Syst."},{"key":"2025032410324705200_r19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000292020","article-title":"Molecular inflammatory mediators in peripheral nerve degeneration and regeneration","volume":"17","author":"C\u00e1mara-Lemarroy","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"2025032410324705200_r20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/BF03401609","article-title":"Interleukin 12: a potential link between nerve cells and the immune response in inflammatory disorders","volume":"1","author":"Turka","year":"1995","journal-title":"Mol. Med."},{"key":"2025032410324705200_r21","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/glia.20766","article-title":"Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease","volume":"56","author":"Martini","year":"2008","journal-title":"Glia"},{"key":"2025032410324705200_r22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1462-5822.2010.01533.x","article-title":"Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes","volume":"13","author":"Mattos","year":"2011","journal-title":"Cell. Microbiol."},{"key":"2025032410324705200_r23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1574-6968.2008.01369.x","article-title":"Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae","volume":"289","author":"Tanigawa","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"2025032410324705200_r24","first-page":"451","article-title":"Histological classification and the immunological spectrum of leprosy","volume":"51","author":"Ridley","year":"1974","journal-title":"Bull. World Health Organ."},{"key":"2025032410324705200_r25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0967-5868(96)90086-7","article-title":"Schwann cell culture from the adult animal sciatic nerve: technique and review","volume":"3","author":"Singh","year":"1996","journal-title":"J. Clin. Neurosci."},{"key":"2025032410324705200_r26","first-page":"477","article-title":"Zenker vs formalin fixation for the histopathology of leprosy tissues and other desirable features of technique","volume":"30","author":"Wade","year":"1962","journal-title":"Int. J. Lepr."},{"key":"2025032410324705200_r27","doi-asserted-by":"crossref","first-page":"27293","DOI":"10.1074\/jbc.M301430200","article-title":"A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system","volume":"278","author":"Marchesan","year":"2003","journal-title":"J. Biol. 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Chem."},{"key":"2025032410324705200_r30","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/01.ATV.0000179676.41064.d4","article-title":"Cytosolic lipid droplets increase in size by microtubule-dependent complex formation","volume":"25","author":"Bostr\u00f6m","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025032410324705200_r31","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1189\/jlb.0106066","article-title":"Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through TLR2-dependent PI3K signaling","volume":"80","author":"Lasunskaia","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2025032410324705200_r32","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1111\/j.1462-5822.2008.01233.x","article-title":"Neutrophils recruited to the site of Mycobacterium bovis BCG infection undergo apoptosis and modulate lipid body biogenesis and prostaglandin E production by macrophages","volume":"10","author":"D\u2019Avila","year":"2008","journal-title":"Cell. Microbiol."},{"key":"2025032410324705200_r33","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/pmic.200800584","article-title":"A role for lipid droplets in inter-membrane lipid traffic","volume":"9","author":"Zehmer","year":"2009","journal-title":"Proteomics"},{"key":"2025032410324705200_r34","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1128\/IAI.71.3.1427-1433.2003","article-title":"Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy","volume":"71","author":"Oliveira","year":"2003","journal-title":"Infect. Immun."},{"key":"2025032410324705200_r35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ni.1836","article-title":"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer","volume":"11","author":"Stewart","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025032410324705200_r36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.coi.2009.12.001","article-title":"The innate immune response in leprosy","volume":"22","author":"Modlin","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"2025032410324705200_r37","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.1087785","article-title":"Use of genetic profiling in leprosy to discriminate clinical forms of the disease","volume":"301","author":"Bleharski","year":"2003","journal-title":"Science"},{"key":"2025032410324705200_r38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nm864","article-title":"Activation and regulation of Toll-like receptors 2 and 1 in human leprosy","volume":"9","author":"Krutzik","year":"2003","journal-title":"Nat. Med."},{"key":"2025032410324705200_r39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/iai.55.2.446-450.1987","article-title":"Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon","volume":"55","author":"Sibley","year":"1987","journal-title":"Infect. Immun."},{"key":"2025032410324705200_r40","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s11064-007-9552-1","article-title":"TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells","volume":"33","author":"Qin","year":"2008","journal-title":"Neurochem. Res."},{"key":"2025032410324705200_r41","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/(SICI)1097-4547(19980915)53:6<747::AID-JNR12>3.0.CO;2-V","article-title":"TNF-alpha and TGF-beta act synergistically to kill Schwann cells","volume":"53","author":"Skoff","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"2025032410324705200_r42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mus.20893","article-title":"The immunocompetence of Schwann cells","volume":"37","author":"Meyer zu H\u00f6rste","year":"2008","journal-title":"Muscle Nerve"},{"key":"2025032410324705200_r43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1054\/plef.2002.0425","article-title":"NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation","volume":"67","author":"Bozza","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2025032410324705200_r44","doi-asserted-by":"crossref","first-page":"11091","DOI":"10.1073\/pnas.93.20.11091","article-title":"Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin","volume":"93","author":"Bozza","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025032410324705200_r45","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1158\/0008-5472.CAN-07-1999","article-title":"Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells","volume":"68","author":"Accioly","year":"2008","journal-title":"Cancer Res."},{"key":"2025032410324705200_r46","doi-asserted-by":"crossref","first-page":"e1000632","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025032410324705200_r47","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bbrc.2005.01.067","article-title":"Inhibition of fatty acid synthase prevents preadipocyte differentiation","volume":"328","author":"Schmid","year":"2005","journal-title":"Biochem. Biophys. Res. 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Med."},{"key":"2025032410324705200_r50","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1471-4159.2010.06646.x","article-title":"Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity","volume":"113","author":"Alvarez","year":"2010","journal-title":"J. Neurochem."},{"key":"2025032410324705200_r51","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1099\/vir.0.82898-0","article-title":"Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus","volume":"88","author":"Boulant","year":"2007","journal-title":"J. Gen. Virol."},{"key":"2025032410324705200_r52","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ncb1631","article-title":"The lipid droplet is an important organelle for hepatitis C virus production","volume":"9","author":"Miyanari","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2025032410324705200_r53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tube.2008.11.001","article-title":"Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosis models","volume":"89","author":"C\u00e1ceres","year":"2009","journal-title":"Tuberculosis (Edinb.)"},{"key":"2025032410324705200_r54","doi-asserted-by":"crossref","first-page":"e1000204","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PLoS Pathog."},{"key":"2025032410324705200_r55","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"Russell","year":"2009","journal-title":"Nat. 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