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Phagocytosis induced NO in a MyD88-dependent fashion. In turn, NO propagated the acidification of phagosomes and the processing of phagosomal bacterial nucleic acids and was required for potent transcriptional activation of cytokine genes by streptococci. This NO-dependent amplification loop has important mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesis.<\/jats:p>","DOI":"10.4049\/jimmunol.1101383","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T04:48:46Z","timestamp":1324356526000},"page":"774-780","source":"Crossref","is-referenced-by-count":15,"title":["NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA"],"prefix":"10.1093","volume":"188","author":[{"given":"Sachin D","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hese","sequence":"additional","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina S","family":"Rauch","sequence":"additional","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Wennekamp","sequence":"additional","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University , Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas T","family":"Golenbock","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Henneke","sequence":"additional","affiliation":[{"name":"Center of Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Center for Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,1,15]]},"reference":[{"key":"2025032409452875900_r1","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.4049\/jimmunol.180.9.6149","article-title":"Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis","volume":"180","author":"Henneke","year":"2008","journal-title":"J. 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