{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:50:22Z","timestamp":1783749022128,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CBA\/J mice infected with the helminth Schistosoma mansoni develop severe CD4 T cell-mediated hepatic granulomatous inflammation against parasite eggs associated with a robust Th17 cell response. We investigated the requisites for Th17 cell development using novel CD4 T cells expressing a transgenic TCR specific for the major Sm-p40 egg Ag, which produce IL-17 when stimulated with live schistosome eggs. Neutralization of IL-23 or blockade of the IL-1 receptor, but not IL-6 neutralization, abrogated egg-induced IL-17 secretion by transgenic T cells, whereas exogenous IL-23 or IL-1\u03b2 reconstituted their ability to produce IL-17 when stimulated by syngeneic IL-12p40\u2013deficient dendritic cells. Kinetic analysis demonstrated that IL-17 production was initiated by IL-23 and amplified by IL-1\u03b2. Significantly, schistosome-infected IL-12p40\u2013deficient or IL-1R antagonist-treated CBA\/J mice developed markedly reduced hepatic immunopathology with a dampened egg Ag-specific IL-17 response. These results demonstrate that the IL-23\u2013IL-1\u2013IL-17 axis has a central role in the development of severe schistosome egg-induced immunopathology.<\/jats:p>","DOI":"10.4049\/jimmunol.1101445","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T23:49:51Z","timestamp":1318636191000},"page":"5328-5335","source":"Crossref","is-referenced-by-count":47,"title":["The Pathogenic Th17 Cell Response to Major Schistosome Egg Antigen Is Sequentially Dependent on IL-23 and IL-1\u03b2"],"prefix":"10.1093","volume":"187","author":[{"given":"Mara G","family":"Shainheit","sequence":"first","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof W","family":"Lasocki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget M","family":"Larkin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene H","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School and Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A","family":"Dinarello","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura I","family":"Rutitzky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel J","family":"Stadecker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tufts University School of Medicine , Boston, MA 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,11,15]]},"reference":[{"key":"2025032410471047100_r1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. 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